Preventive Effect of Hydrogen Water on the Development of Detrusor Overactivity in a Rat Model of Bladder Outlet Obstruction

Miyazaki, Nozomu; Yamaguchi, Osamu; Nomiya, Masanori; Aikawa, Kohsuke; Kimura, Junko

doi:10.1016/j.juro.2015.10.117

Cited by 24 publications

(36 citation statements)

References 28 publications

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“…The following cystometric parameters were investigated: cystometric pressure and volume parameters, including basal pressure (BP, the lowest bladder pressure between two micturitions), micturition pressure (MP, maximum bladder pressure during micturition), threshold pressure (TP, bladder pressure at onset of micturition), intermicturition pressure (IMP, mean bladder pressure between two micturitions), spontaneous activity (SA, IMP−BP), micturition interval (MI), MV (micturition volume), bladder capacity (BC, MV+ RV) and voiding efficiency (VE, MV/BC micturition volume divided by bladder capacity) (18). DO was defined as obvious increase in voiding and/or non-voiding contraction, with the latter defined as IVP rises from baseline pressure without a release of fluid from the urethra (19).…”

Section: Bladder Cystometrymentioning

confidence: 99%

Proteomic Analysis of Urothelium of Rats with Detrusor Overactivity Induced by Bladder Outlet Obstruction

Park

Lim

Kim

et al. 2018

Molecular & Cellular Proteomics

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SummaryOveractive bladder (OAB) syndrome is a condition that has four symptoms: urgency, urinary frequency, nocturia, and urge incontinence and negatively affects a patient's life. Recently, it is considered that the urinary bladder urothelium is closely linked to pathogenesis of OAB. However, the mechanisms of pathogenesis of OAB at the molecular level remain poorly understood, mainly as a result of lack of modern molecular analysis. The goal of this study is to identify a potential target protein that could act as a predictive factor for effective diagnosis and aid in the development of therapeutic strategies for the treatment of OAB syndrome. We produced OAB in a rat model and performed the first proteomic analysis on the mucosal layer (urothelium) of the bladders of sham control and OAB rats. The resulting data revealed the differential expression of 355 proteins in the bladder urothelium of OAB rats compared to sham subjects. Signaling pathway analysis revealed that the differentially expressed proteins were mainly involved in the inflammatory response and apoptosis.Our findings suggest a new target for accurate diagnosis of OAB that can provide essential information for the development of drug treatment strategies as well as establish criteria for screening patients in the clinical environment.

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Section: Bladder Cystometrymentioning

confidence: 99%

Proteomic Analysis of Urothelium of Rats with Detrusor Overactivity Induced by Bladder Outlet Obstruction

Park

Lim

Kim

et al. 2018

Molecular & Cellular Proteomics

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“…Similar to trauma and foreign body stimulation, the effect of cystostomy on bladder function in rats might include acute and chronic inflammation responses; the former will soon disappear but the latter will accumulate with time. Considering the impact of cystostomy on bladder function and to avoid disturbances caused by acute inflammation, many researchers usually do not perform cystometry immediately after cystostomy but several days after . However, the best time window for performing cystometry postcystostomy is still unclear and there has been very little relevant research.…”

Section: Introductionmentioning

confidence: 99%

Changes in bladder function with time following cystostomy in rats

Chen

Wen

et al. 2019

Neurourology and Urodynamics

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Aims: To investigate bladder function patterns following cystostomy and determine the best time window for cystometric evaluation of bladder function in conscious rats.Materials and Methods: Cystostomy was performed in rats of the first seven groups; thereafter, cystometry was performed in the designed time interval.Noncystostomy rats of group 8 voided freely as control. Basal bladder pressure (P ves.basal ), maximum bladder pressure (P ves.max ), bladder threshold pressure (P ves.thre ), voiding interval (VI), bladder contraction duration (CD) , bladder compliance (ΔC), voided volume (VV), postvoiding residual urine (PVR), and bladder capacity (BC) were recorded and compared with cystostomy groups, with VV, PVR, BC compared with the control values. Bladders were collected after the urodynamic study for weighing, hematoxylin-eosin, and Masson staining to investigate pathological changes.Results: P ves.basal , P ves.max , and P ves.thre trended downward, while BC, VI, VV, and ΔC trended upward on days 1 to 5 postcystostomy. BC and VV significantly decreased on days 1 to 3 postcystostomy compared with control values; on days 5 to 15 postcystostomy, P ves.basal , P ves.max , P ves.thre , VI, VV, BC, and PVR were stable, and BC, VV, and PVR showed no significant differences from the control values. However, on day 21 postcystostomy, BC increased significantly compared with the controls. Bladder weight increased in the cystostomy groups compared with the controls. Pathological analysis showed severe acute bladder inflammation on days 1 to 3, mild inflammation on days 5 to 15, and increased collagen deposition in bladder tissue on day 21 postcystostomy. Conclusion: Cystometric evaluation of bladder function in conscious rats is best performed on days 5 to 15 postcystostomy. K E Y W O R D Sbladder, collagen, cystometry, cystostomy, HE staining, Masson staining, rat

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“…These pathological changes do not typically occur in human patients with pBOO. Fourth, recent studies have focused on bladder ischemia caused by pBOO . The rodent bladder is oval‐shaped, and bladder vessels depart from the bladder neck.…”

Section: Discussionmentioning

confidence: 99%

“…Sidler et al found that the invasive manipulation and dissection around the bladder neck partially disrupts bladder innervation and the resulting bladder neck bladder‐body cross‐talk via denervation. While several recent studies have demonstrated that bladder ischemia and oxidative stress mediate the bladder wall remodeling in pBOO, mechanical stimuli were previously were believed to cause these effects . Researchers have reached dramatically different conclusions regarding the mechanism of pBOO, suggesting that the traditional open surgery model is not sufficiently stable, and these changes may not always be detected.…”

Section: Introductionmentioning

confidence: 99%

Suture causing urethral meatus stricture: A novel animal model of partial bladder outlet obstruction

Chen

Yang

et al. 2018

Neurourology and Urodynamics

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Preventive Effect of Hydrogen Water on the Development of Detrusor Overactivity in a Rat Model of Bladder Outlet Obstruction

Cited by 24 publications

References 28 publications

Proteomic Analysis of Urothelium of Rats with Detrusor Overactivity Induced by Bladder Outlet Obstruction

Proteomic Analysis of Urothelium of Rats with Detrusor Overactivity Induced by Bladder Outlet Obstruction

Changes in bladder function with time following cystostomy in rats

Suture causing urethral meatus stricture: A novel animal model of partial bladder outlet obstruction

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