Preventive Effect of Hydrazinocurcumin on Carcinogenesis of Diethylnitrosamine-induced Hepatocarcinoma in Male SD Rats

Zhao, Jian; Peng, Li; Chen, Geng; Liu, Yueping; Wang, Xu; Yang, Hongjiang; Wang, Shijie

doi:10.7314/apjcp.2014.15.5.2115

Cited by 23 publications

(25 citation statements)

References 34 publications

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“…Since the serum ALT and AST can better reflect the extent of liver damage, they are the key indexes measuring the level of liver injury. Zhao JA et al (2014) demonstrated that diethylnitrosamine (DEN) induced severe histological and immunohistochemical changes in liver tissues, significantly increasing the levels of liver marker enzymes such as ALT and AST. Taken together, their results suggested application of curcumin (CUR) and hydrazinocurcumin (HZC) could prevent the occurrence of carcinogenesis and HZC may be a more potent compound for prevention of DEN-induced hepatocarcinogenesis in rats than CUR (Zhao JA et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Zhao JA et al (2014) demonstrated that diethylnitrosamine (DEN) induced severe histological and immunohistochemical changes in liver tissues, significantly increasing the levels of liver marker enzymes such as ALT and AST. Taken together, their results suggested application of curcumin (CUR) and hydrazinocurcumin (HZC) could prevent the occurrence of carcinogenesis and HZC may be a more potent compound for prevention of DEN-induced hepatocarcinogenesis in rats than CUR (Zhao JA et al, 2014). Duh PD et al (2010) investigated the in vitro and in vivo protective effects of water extract of pu-erh tea (WEPT) on tert-butyl-hydroperoxide (t-BHP)-induced oxidative damage in hepatocytes of HepG2 cells and in rat livers.…”

Section: Discussionmentioning

confidence: 99%

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Pu-erh Tea Powder Preventive Effects on Cisplatin-Induced Liver Oxidative Damage in Wistar Rats

Zheng¹,

Wang²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (17), 7389-7394 IntroductionChemotherapy is one of the major means for malignancy. It seeks to shrink tumors, decrease cancerrelated symptoms, advance quality of life, lengthen life spans of patients, and so on. Many studies have shown the effectiveness and feasibility of chemotherapy for cancers species involving the lung, pancreas, liver, large intestine, and so on. Conversely, treatment with anticancer drugs can also do harm to patients' normal tissues and organs, and those toxicities may lead to a worsened quality of life and shortened survival.Cisplatin (cis-diamminedichloroplatinumⅡ, CDDP) is one of the main chemotherapeutics, which is widely used for the treatment of various malignant solid tumors such as ovarian, lung, testicular and head and neck cancers (Pfister et al., 2010;Dimri et al., 2013; Dua et al., 2013;Besse et al., 2014 AbstractBackground: Chemotherapy is one of the major means for control of malignancies, with cisplatin (CDDP) as one of the main agents, widely used for the treatment of various malignant solid tumors. However, prevention of hepatotoxicity from cisplatin is one of the urgent issues in cancer chemotherapy. In this study, we aimed to investigate the effects of pu-erh tea on hepatotoxicity through body weight and tissue antioxidant parameters like, liver coefficient, serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), malondialdehyde(MDA) and glutathione (GSH) levels, and light microscopic evaluation by histological findings. Materials and Methods: The rats were randomly divided into five groups: Control (n=10), cisplatin (3 mg/kg p.i., n=10), cisplatin+pu-erh (0.32 g/kg/day i.g., n=10), cisplatin+pu-erh (0.8 g/kg/day i.g., n=10) and cisplatin+pu-erh (1.6 g/kg/day i.g., n=10). Pu-erh tea powder was administrated for 31 consecutive days. The rats were sacrificed at the end on the second day after a single dose of cisplatin treatment for measuring indices. Results: Pu-erh tea powder exhibited a protective effect by decreasing MDA and GSH and increasing the SOD and GSH-PX levels and GSH-PX/MDA ratio in camparison with the control group. Besides, pu-erh tea was also able to alleviate the pathological damage to some extent. Conclusion: Pu-erh tea powder is protective against cisplatin-induced liver oxidative damages, especially at the medium dosage (0.8 g/kg/d).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pu-erh Tea Powder Preventive Effects on Cisplatin-Induced Liver Oxidative Damage in Wistar Rats

Zheng¹,

Wang²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…ALP level elevates linearly with the tumour mass and is considered to be important marker during diagnosis in early detection of cancer. 27 MESA at dose of 200 mg/kg and 400 mg/kg decreased the elevated levels of these biochemical parameters in a dose dependant manner. Extract tends to prevent liver damage by maintaining integrity of plasma membrane thereby supressing the leakage of enzyme through membranes, exhibiting hepatoprotective activity.…”

Section: Histopathological Examination Of Hepatic Tissuesmentioning

confidence: 85%

Antineoplastic Approach of Semecarpus anacardium Leaves Against N-Nitroso Diethylamine Initiated Hepatocellular Carcinoma

Upreti¹,

Sv²,

Das³

et al. 2018

IJPER

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Objective: To evaluate the effect of MESA on NDEA induced hepatocellular carcinoma on Sprague Dawley rats. Methodology: Semecarpus anacardium commonly known as 'marking nut tree' is a rich antioxidant and in Ayurveda it has been used for treatment of various forms of cancer. Methanolic extract of leaves of Semecarpus anacardium (MESA) was studied for its potential antioxidant property both in vitro and in vivo. NDEA 200 mg/kg, single i.p was the hepatocarcinogen while 200 mg/kg and 400 mg/kg of MESA was administered daily orally for 12 weeks. Protective effect of MESA was evaluated by measuring biochemical parameters like SGOT, SGPT, ALP and LDH. Alpha fetoprotein test was performed and histopathology changes of livers were assessed. Results: Preliminary phytochemical study revealed the presence of flavonoids, tannins, steroids, alkaloids, glycosides and vitamin C. MESA restored the level of antioxidants near to normal and reduced the elevated serum level of SGOT, SGPT, AST, LDH and AFP. The histopathology changes i.e. necrosis, widened sinusoids, elevated inflammatory cell infiltrate were partly or fully prevented in animals treated with the extract. Conclusion:The result of the present study indicates MESA to be rich in antioxidants and its active constituents mediated the free radical scavenging activity. 400 mg/kg extract showed promising effect in management of primary liver cancer.

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“…SK-HEP-1 cells were seeded in 6-well plates at a density of 5x10 5 cells/well for 24 h at 37˚C, incubated with 20 µM Z-DEVD-FMK (Santa Cruz Biotechnology Inc., Santa Cruz, CA, USA) or vehicle for 1 h, followed by treatment with various concentrations of GL63 and CUR (0, 10, 20 and 40 µM) for 24 h. All cells were collected and washed twice with cold PBS. Next, the cells were collected and resuspended in 100 µl binding buffer containing annexin V and PI.…”

Section: -(45-dimethylthiazol-2-yl)-25-diphenyltetrazolium Bromidementioning

confidence: 99%

“…However, this can be performed only in selected patients whose tumors are small and located away from major vessels and have not metastasized to extrahepatic organs (4). No chemotherapy agent has better benefit than surgery in controlled clinical trials due to different reasons, including drug resistance and toxicity to normal cells (5).…”

Section: Introductionmentioning

confidence: 99%

A novel curcumin analogue is a potent chemotherapy candidate for human hepatocellular carcinoma

et al. 2016

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Abstract. Curcumin (CUR) has been demonstrated to protect against carcinogenesis and to prevent tumor development in cancer; however, the clinical application of CUR is limited by its instability and poor metabolic properties. The present study offers an strategy for a novel CUR analogue, (1E,4E)-1,5-bis(2-bromophenyl)penta-1,4-dien-3-one (GL63), to be used as a potential therapeutic agent for hepatocellular carcinoma (HCC) in vitro and in vivo. The current study demonstrated that GL63 exhibited more potent inhibition of proliferation of HCC cells than CUR. GL63 induced G0/G1 phase cell cycle arrest and apoptosis in SK-HEP-1 cells in a dose-dependent manner, and was more potent than CUR, according to the flow cytometry data. The present study demonstrated for the first time that the inhibition of the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway by GL63 resulted in a protective effect against HCC cell growth. GL63 was more effective than CUR in regulating STAT3 downstream targets, which contributed to the suppression of cell proliferation and the induction of cell apoptosis. In addition, the effects of GL63 were tested in a model of N-nitrosodiethylamine (DEN)-induced HCC in Wistar rats. Although macroscopic and microscopic features suggested that both GL63 and CUR were effective in inhibiting DEN-induced hepatocarcinogenesis, GL63 exerted a stronger effect than CUR. Immunohistochemical analysis for proliferating cell nuclear antigen demonstrated significant differences among the DEN-bearing non-treated, DEN-bearing GL63-treated and DEN-bearing, CUR-treated groups (P=0.039). It was concluded that GL63 was a potent agent able to suppress the proliferation of HCC cells by inhibition of the JAK2/STAT3 signaling pathway, with more favorable pharmacological activity than CUR, and may be a more potent compound for the prevention of DEN-induced hepatocarcinogenesis in rats than CUR.

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Preventive Effect of Hydrazinocurcumin on Carcinogenesis of Diethylnitrosamine-induced Hepatocarcinoma in Male SD Rats

Cited by 23 publications

References 34 publications

Pu-erh Tea Powder Preventive Effects on Cisplatin-Induced Liver Oxidative Damage in Wistar Rats

Pu-erh Tea Powder Preventive Effects on Cisplatin-Induced Liver Oxidative Damage in Wistar Rats

Antineoplastic Approach of Semecarpus anacardium Leaves Against N-Nitroso Diethylamine Initiated Hepatocellular Carcinoma

A novel curcumin analogue is a potent chemotherapy candidate for human hepatocellular carcinoma

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