Preventive effect of fermented Gelidium amansii and Cirsium japonicum extract mixture against UVB-induced skin photoaging in hairless mice

Kim, Hyun Mee; Lee, Dong‐Eun; Park, Soo Dong; Kim, Yong Tae; Kim, Yu Jin; Jeong, Ji Woong; Lee, Jung‐Hee; Jang, Sung Sik; Chung, Dae Kyun; Sim, Jae-Il; Huh, Chul‐Sung

doi:10.1007/s10068-014-0085-5

Cited by 7 publications

(3 citation statements)

References 38 publications

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“…Corallina pilulifera inhibits the MMP-2 and MMP-9 expression and free radical oxidation against UV-induced photoaging in vitro [27]. Fermented Gelidium amansii and Cirium japonicum extract mixture ameliorated UVB-induced ECM remodeling in vitro, and attenuated photodamage via an anti-wrinkle effect and a moisturizing effect in vivo [28]. Another alga, Polysiphonia morrowii Harvey, has a photo-protective effect by apoptosis inhibition and antioxidant enzyme induction [29].…”

Section: Discussionmentioning

confidence: 99%

“…These phlorotannins are abundant in brown algae and have been reported to have a variety of health-beneficial biological activities, including antioxidant [22,23], various enzyme inhibitory [24,25], and radioprotective effect [26]. In addition, previous papers reported several algae possessed anti-photoaging effects against UV [27][28][29]. Eisenia bicyclis (Kjellman) Setchell (E. bicyclis) is a very common brown alga that belongs to the family Laminariaceae and generally inhabits the middle Pacific coast around Korea, Japan, and China.…”

Section: Introductionmentioning

confidence: 99%

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Eisenia bicyclis Extract Repairs UVB-Induced Skin Photoaging In Vitro and In Vivo: Photoprotective Effects

et al. 2021

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Chronic exposure to ultraviolet B (UVB) is a major cause of skin aging. The aim of the present study was to determine the photoprotective effect of a 30% ethanol extract of Eisenia bicyclis (Kjellman) Setchell (EEB) against UVB-induced skin aging. By treating human dermal fibroblasts (Hs68) with EEB after UVB irradiation, we found that EEB had a cytoprotective effect. EEB treatment significantly decreased UVB-induced matrix metalloproteinase-1 (MMP-1) production by suppressing the activation of mitogen-activated protein kinase (MAPK)/activator protein 1 (AP-1) signaling and enhancing the protein expression of tissue inhibitors of metalloproteinases (TIMPs). EEB was also found to recover the UVB-induced degradation of pro-collagen by upregulating Smad signaling. Moreover, EEB increased the mRNA expression of filaggrin, involucrin, and loricrin in UVB-irradiated human epidermal keratinocytes (HaCaT). EEB decreased UVB-induced reactive oxygen species (ROS) generation by upregulating glutathione peroxidase 1 (GPx1) and heme oxygenase-1 (HO-1) expression via nuclear factor erythroid-2-related factor 2 (Nrf2) activation in Hs68 cells. In a UVB-induced HR-1 hairless mouse model, the oral administration of EEB mitigated photoaging lesions including wrinkle formation, skin thickness, and skin dryness by downregulating MMP-1 production and upregulating the expression of pro-collagen type I alpha 1 chain (pro-COL1A1). Collectively, our findings revealed that EEB prevents UVB-induced skin damage by regulating MMP-1 and pro-collagen type I production through MAPK/AP-1 and Smad pathways.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Eisenia bicyclis Extract Repairs UVB-Induced Skin Photoaging In Vitro and In Vivo: Photoprotective Effects

et al. 2021

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“…Romaris et al previously demonstrated a high bioavailability of iron in a red alga seaweed in an in vitro study, which also had high dialyzable bromine percentages [ 26 ]. Moreover, Bouhlal Rhimou et al investigated the UV protective effect of Gelidium amansii and showed that a Gelidium amansii extract, enriched by a biosorption process, increased absorption over the control group [ 27 ]. We believe that the bioavailability of GEE improves the strength of the scientific evidence provided by our study.…”

Section: Discussionmentioning

confidence: 99%

Single, 14-Day, and 13-Week Repeated Dose Toxicity Studies of Daily Oral Gelidium elegans Extract Administration to Rats

et al. 2018

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Gelidium elegans extract (GEE) is derived from a red alga from the Asia–Pacific region, which has antioxidant, anti-adipogenic, and anti-hyperglycemic effects. However, detailed studies of the toxicology of GEE have not been performed. We evaluated the single oral dose toxicity of GEE in male and female Sprague-Dawley (CD) rats. GEE did not cause deaths or have toxic effects at dosages of 5000 mg/kg/day, although compound-colored stools and diarrhea were observed in both sexes, which lasted <2 days. Therefore, the LD50 of GEE is likely to be >5000 mg/kg. We next evaluated the repeated oral dose toxicity of GEE in CD rats over 14 days and 13 weeks. GEE did not induce any significant toxicological changes in either sex at 2000 mg/kg/day. Repeated oral dose toxicity studies showed no adverse effects, in terms of clinical signs, mortality, body mass, food consumption, ophthalmic examination, urinalysis, hematology, serum biochemistry, necropsy, organ masses, or histopathology, at dosages of 500, 1000, or 2000 mg/kg/day. The no observed adverse effect level (NOAEL) for GEE is thus likely to be >2000 mg/kg/day, and no pathology was identified in potential target organs. Therefore, this study indicates that repeated oral dosing with GEE is safe in CD rats.

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A concise review of the potential utilization based on bioactivity and pharmacological properties of the genus Gelidium (Gelidiales, Rhodophyta)

et al. 2023

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Preventive effect of fermented Gelidium amansii and Cirsium japonicum extract mixture against UVB-induced skin photoaging in hairless mice

Cited by 7 publications

References 38 publications

Eisenia bicyclis Extract Repairs UVB-Induced Skin Photoaging In Vitro and In Vivo: Photoprotective Effects

Eisenia bicyclis Extract Repairs UVB-Induced Skin Photoaging In Vitro and In Vivo: Photoprotective Effects

Single, 14-Day, and 13-Week Repeated Dose Toxicity Studies of Daily Oral Gelidium elegans Extract Administration to Rats

A concise review of the potential utilization based on bioactivity and pharmacological properties of the genus Gelidium (Gelidiales, Rhodophyta)

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