Preventive effect of Elateriospermum tapos seed extract against obese Sprague Dawley rats

Perumal, Kokila Vani; Ja’afar, Nor Liyana; Balan, Santhra Segaran; Abidin, Azrina Zainal; Arapoc, Daryl Jesus; Shafie, Nurul Husna; Bahari, Hasnah

doi:10.1007/s13596-019-00394-w

Cited by 10 publications

(16 citation statements)

References 23 publications

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“…According to the results, the HF and CAF diet-induced rats significantly gained weight as compared to rats fed with standard chow diet. These findings were similar to a previous study that showed body weight gain due to hyperphagia in rats [ 10 ]. Both energy-dense and palatable diets introduced to the rats contributed to fat hyperphagia and reduced sensitivity to peptide satiety, which resulted in overeating leading to obesity [ 11 ].…”

Section: Discussionsupporting

confidence: 93%

“…With such consequences, natural resources have been used for obesity treatment on top of having lower toxicity, they also have fewer side effects, as compared to antiobesity drugs [ 5 , 10 ]. In the current study, we analyzed the anti-obesity activity of E. tapos shell extract in obesity-induced Sprague Dawley rats.…”

Section: Discussionmentioning

confidence: 99%

“…The sectioned tissue sample was placed on slides and was stained with hematoxylin and eosin (H&E). The slides were examined under a light microscope [ 10 ].…”

Section: Methodsmentioning

confidence: 99%

“…Previously, Perumal et al conducted a study on the anti-obesity effect of E. tapos seed extract at different dosages of 5 mg/kg, 25 mg/kg, and 125 mg/kg in Sprague Dawley rats, whereby it positively affected the body weight, caloric intake, lipid profile, and histopathology [ 10 ]. As of today, no study has highlighted the potential role of E. tapos shell against obesity.…”

Section: Introductionmentioning

confidence: 99%

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Antiobesity Activity of Elateriospermum tapos Shell Extract in Obesity-Induced Sprague Dawley Rats

et al. 2021

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Obesity is one of the risk factors associated with cardiovascular diseases, hypertension, abnormal liver function, diabetes, and cancers. Orlistat is currently available to treat obesity, but it is associated with adverse side effects. Natural resources are widely used for obesity treatment. Hence, this study aimed to investigate the anti-obesity activity of Elateriospermum tapos (E. tapos) shell extract in obesity induced Sprague Dawley rats. The rats’ obesity was induced by a high-fat (HF) diet made up of 50% standard rat pellet, 20% milk powder, 6% corn starch, and 24% ghee and a cafeteria (CAF) diet such as chicken rolls, salty biscuits, cakes, and cheese snacks. A hot aqueous method for the extraction of E. tapos shells was applied by using 500 mL of distilled water for about 24 h. Various dosages of E. tapos shell extract (10 mg/kg, 100 mg/kg, and 200 mg/kg) were used. At the end of the study, body weight, caloric intake, organ weight, lipid profile, lipoprotein lipase (LPL) activity, and histopathology analysis were carried out. E. tapos shell extract treated groups showed a reduction in body weight, positive lipid-lowering effect, decrements in triglyceride accumulation and LPL activity, and positive improvement in histopathology analysis. A dose of 200 mg/kg showed the most effective result compared to 10 mg/kg and 100 mg/kg doses.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

“…The sectioned tissue sample was placed on slides and was stained with hematoxylin and eosin (H&E). The slides were examined under a light microscope [ 10 ].…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antiobesity Activity of Elateriospermum tapos Shell Extract in Obesity-Induced Sprague Dawley Rats

et al. 2021

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“…Next, the filtrate underwent the freezedrying process to obtain an extract powder. E. tapos shell and seed powder were kept in a flacon tube and stored at under −20 °C [6].…”

Section: Elateriospermum Tapos Extractionmentioning

confidence: 99%

Elacteriospermum tapos Ameliorates Maternal Obesity Effect on Serum Leptin Changes in Male Offspring

Balan

Abidin

Perumal

et al. 2020

First International Electronic Conference on Nutrients, Microbiota and Chronic Disease

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The purpose of this study is to investigate the effect of Elateriospermum tapos aqueous extract supplementation on serum leptin of male offspring at weaning. A total of 30 female Sprague Dawley rats were assigned to two groups, where the control group (CG) consisted of six rats and the remaining rats had obesity-induced over five weeks with a high-fat diet pellet and cafeteria food. After five weeks, the obese group was further divided into four groups, a negative control group (NG), positive control group (PG) (orlistat 200 mg/kg), treatment 1 (TX1) (200 mg/kg BW of E. tapos seed) and treatment 2 (TX2) (200 mg/kg BW of E. tapos shell) for 6 weeks. After six weeks, all rats were mated and continued with their respective diet till weaning. One male pup from each dam culled at weaning (postnatal day 21 (PND21)). The results show that body weight in male offspring (M) from negative group dams (NG) was significantly heavier as compared to other pup groups. Total adipose tissue weight in MTX1 and MTX2 of the male offspring was also significantly lower compared to MNG. In mums, serum leptin of NG was significantly higher as compared to the CG group, whereas both treatment groups showed a significant reduction in serum leptin compared to the NG group. In pups, the MTX2 group showed a more substantial reduction in body weight and serum leptin compared to other pups from other mother’s groups. In conclusion, E. tapos aqueous extract supplementation has a greater effect on ameliorating maternal obesity effects on male offspring by lowering body weight, inhibit fat deposition, and reducing serum leptin.

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Protective effect of Elateriospermum tapos in maternal obesity-induced deficit cognitive function of the offspring

Abidin

Rosli

Santhra

et al. 2021

Journal of Basic and Clinical Physiology and Pharmacology

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Objectives Pre-pregnancy obesity is a serious epidemics concern that negatively affects the neurodevelopmental of the offspring. Elateriospermum tapos (E. tapos) commonly used to enhance weight loss in obesity treatment. This study was aimed to investigate the influence of E. tapos supplement in obese maternal prior pregnancy on the offspring’s bodyweight, lipid metabolism and memory function. Methods Thirty female Sprague Dawley rats were used. Six rats were assigned to the normal diet group (DND). The remaining rats were fed with a high-fat and cafeteria diet (HFCD) to generate obesity for 5 weeks. Obese rats were further divided into four groups: Negative Control (DNC; HFCD), Positive Control (DPC; Orlistat 200 mg/kg), treatment 1 (DTX1; E. tapos seed 200 mg/kg) and treatment 2 (DTX2, E. tapos shell 200 mg/kg) were given daily, for 6 weeks prior to mating. At weaning, offspring of both genders were designated into six groups according to their dam’s group (n=6/group). All groups were fed with a cafeteria diet except for the control group. Memory tasks for object and place recognition were conducted on offspring at eighth weeks of age. The offspring were cull at the 12th week of age for their blood sample. Results Both offspring genders from DTX2 significantly reduce bodyweight, calorie intake and triglyceride level. In memory tasks, offspring from DTX2 showed a significant increase in exploration rate in place test as compared to offspring from the DNC group. Conclusions This study highlights E. tapos shell as an anti-obesity agent and protecting memory deficit in obese dam’s offspring.

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Preventive effect of Elateriospermum tapos seed extract against obese Sprague Dawley rats

Cited by 10 publications

References 23 publications

Antiobesity Activity of Elateriospermum tapos Shell Extract in Obesity-Induced Sprague Dawley Rats

Antiobesity Activity of Elateriospermum tapos Shell Extract in Obesity-Induced Sprague Dawley Rats

Elacteriospermum tapos Ameliorates Maternal Obesity Effect on Serum Leptin Changes in Male Offspring

Protective effect of Elateriospermum tapos in maternal obesity-induced deficit cognitive function of the offspring

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