Preventive Effect of Dapsone on Renal Scarring following Mannose-Sensitive Piliated Bacterial Infection

Mochida, O.; Matsumoto, Tetsuro; Mizunoe, Yoshimitsu; Sakumoto, Misao; Abe, Jiro; Kumazawa, Joichi

doi:10.1159/000007088

Cited by 10 publications

(6 citation statements)

References 20 publications

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“…Other studies with oxytocin [28], melatonin [24,27], pentoxifylline [36], vitamin A [37], and montelukast [30] (a selective leukotriene CyslT1 receptor antagonist) showed the same result. Anti-inflammatory drugs such as glucocorticoids [23,31,32], ulinastatin [38], ibuprofen [25], and dapsone [39] significantly inhibited renal scarring in animal models. However, few researches noted the failure of dexamethasone [26] and hydrocortisone [40] to prevent renal damage following acute pyelonephritis.…”

Section: Discussionmentioning

confidence: 99%

The role of dexamethasone on decreasing urinary cytokines in children with acute pyelonephritis

Sharifian

Anvaripour

Karimi³

et al. 2008

Pediatr Nephrol

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Cytokines play a major role in renal scar formation following febrile urinary tract infection (UTI). We investigated the role of dexamethasone combined with antibiotics in diminishing urinary interleukin-6 (UIL-6) and UIL-8 concentrations during the acute phase of pyelonephritis compared with standard antibiotic therapy. UIL-6 and UIL-8 concentrations were determined by enzyme immunoassay in 34 children with pyelonephritis who were treated with ceftriaxone plus dexamethasone (case group) and in 20 patients with the same diagnosis treated with ceftriaxone alone (control group). Urine samples were obtained at the time of presentation prior to drug administration and at follow-up 72 h after initiation of medication. Creatinine concentrations were also determined, and cytokine/creatinine ratios were calculated to standardize samples. Differences between cytokine/creatinine ratios in initial and follow-up urine samples were significant in the case group (P < 0.001) but not for controls. In addition, combined antibiotic and dexamethasone significantly decreased UIL-6 and UIL-8 concentrations compared with antibiotic alone (P < 0.05). We conclude that dexamethasone combined with antibiotics significantly decreases UIL-6 and UIL-8 levels in patients with acute pyelonephritis. This suggests that the clinical use of corticosteroids may prevent scar formation following febrile UTI.

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Section: Discussionmentioning

confidence: 99%

The role of dexamethasone on decreasing urinary cytokines in children with acute pyelonephritis

Sharifian

Anvaripour

Karimi³

et al. 2008

Pediatr Nephrol

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“…From the report by Yagmurlu et al, it is showed that anticytokine activity of pentoxifylline could be the other mechanism for the prevention of renal scarring due to pyelonephritis, though this study did not include cytokine measurements [9]. The preventive effect of dapsone which has a scavenging activity on active oxygen species on renal scarring was found to effectively prevent renal scarring by Mochida et al [16]. Caffeic acid phenethyl ester (an active component of propolis from honeybee hives, which has antioxidant, anti-inflammatory, and antibacterial properties) administration reduced significantly decreased E. coli -induced lipid peroxidation as showed by Celik et al [20].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, ongoing research projects are underway to find an agent that can prevent renal scarring and subsequent complications. Inhibition of acute inflammation in experimental studies by steroids [3, 5], anti-inflammatory agents [6, 7], melatonin [8], pentoxifylline [9], vitamin A [10], vitamins A and E [11], vitamins C and E [12], vitamin E [13], mesenchymal stem cell [14], methylene blue [15], dapsone [16], ulinastatin [17], and montelukast [18] have been reported to reduce kidney damage after infection.…”

Section: Introductionmentioning

confidence: 99%

Could Pyelonephritic Scarring Be Prevented by Anti-Inflammatory Treatment? An Experimental Model of Acute Pyelonephritis

Özdoğan

Özdemir

İmamoğlu

et al. 2014

BioMed Research International

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Objectives. This study aimed to demonstrate if the addition of anti-inflammatory treatment to antibiotic therapy shows any superiority to the treatment with antibiotic only. Methods. Forty-nine Wistar rats were divided into 7 groups. Pyelonephritis was performed by E. coli injection to upper pole of kidneys except control group. Group 2 was not treated. Ceftriaxone, ketoprofen, “ceftriaxone + ketoprofen,” methylprednisolone, and “ceftriaxone + methylprednisolone” were given in the groups. The technetium-99m-dimercaptosuccinic acid scintigraphies were performed in 3rd day to detect pyelonephritis and 10th week to detect renal scarring. All kidneys were also histopathologically evaluated. Results. When 3rd day and 10th week scintigraphies were compared, initial 2.00 ± 0.30 point pyelonephritis score resulted in 0.71 ± 0.36 renal scar score in “ceftriaxone + ketoprofen” group (P = 0.039). Initial 2.00 ± 0.43 point pyelonephritis score resulted in 0.86 ± 0.26 renal scar score in “ceftriaxone + methylprednisolone” group (P = 0.041). Renal scar score was declined in “ceftriaxone + ketoprofen” group and “ceftriaxone + methylprednisolone” group compared with no-treatment group on 10th week of the study (P = 0.026, P = 0.044). On histopathological evaluation, it was seen that renal scar prevalence and expansion declined significantly in “ceftriaxone + ketoprofen and ceftriaxone + methylprednisolone” (P = 0.011, P = 0.023). Conclusion. It was evidenced that ceftriaxone treatment in combination with ketoprofen or methylprednisolone declined scar formation in scintigraphic and histopathologic examinations of the kidneys.

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“…Dapson, as a free oxygen radical scavenger, prevents renal scar formation with a dose of 20 mg/kg in the experimental pyelonephritis model [36] . Ulinastatin is an elastase inhibitor presented in PMN leukocytes.…”

Section: Discussionmentioning

confidence: 99%

Effect of a Selective Cyclooxygenase-2 Inhibitor on Renal Scarring

Küçük¹,

Bingul²,

Kurt³

et al. 2006

Eur Surg Res

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Background: Scarring is one of the steps of excessive wound healing, causing dysfunction of the involved tissues and clinically poor cosmetics. The aim of this study was to examine the effect of a highly selective cyclooxygenase-2 (COX-2) inhibitor on renal scar formation in experimental pyelonephritis. Materials and Methods: Four groups of 10 Balb/C mice were formed. In groups I and II following the inoculation of lipopolysaccharide (LPS) into both kidneys, 0.18 and 0.36 mg/day of rofecoxib was given respectively via intraperitoneal route for 5 days. No medication was applied following physiological saline solution injection to both kidneys of the mice in group III (negative control group). After group IV’s LPS inoculation on the first day, saline solution (1 ml/day) was given intraperitoneally for 5 days (positive control group). Following the exposure of both kidneys, LPS of Escherichia coli (5 mg/kg) was injected into the kidneys of groups I, II, and IV. In group III, saline solution (0.1 ml) was used instead of LPS. Three days after the inoculation of LPS, solutions containing 0.18 and 0.36 mg of COX-2 inhibitor were given intraperitoneally for 5 days in groups I and II. No medication was used for the mice in group III. Six weeks after the inoculation of LPS and saline solution, all mice were humanely euthanized. Bilateral nephrectomies were done on each group of mice, and histopathological examination was performed. Results: Inoculation of LPS into the renal parenchyma caused pyelonephritis and scar formation in all groups. The degree of pyelonephritis and scar formation was lesser in groups in which COX-2 inhibitors were used. The degree of scar formation was lesser in group II, in which 0.36 mg more of COX-2 inhibitor was used than in group I (0.18 mg of COX-2 inhibitor). Conclusion: In our study model, direct inoculation of LPS to kidneys caused experimentally induced pyelonephritis. Renal scar formation was effectively prevented through the utilization of rofecoxib at 0.36-mg doses.

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Preventive Effect of Dapsone on Renal Scarring following Mannose-Sensitive Piliated Bacterial Infection

Cited by 10 publications

References 20 publications

The role of dexamethasone on decreasing urinary cytokines in children with acute pyelonephritis

The role of dexamethasone on decreasing urinary cytokines in children with acute pyelonephritis

Could Pyelonephritic Scarring Be Prevented by Anti-Inflammatory Treatment? An Experimental Model of Acute Pyelonephritis

Effect of a Selective Cyclooxygenase-2 Inhibitor on Renal Scarring

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