Preventive effect of chemical peeling on ultraviolet induced skin tumor formation

A Comparative Study of Glycolic Acid Versus Mixture of Trichloroacetic Acid and Glycolic Acid Peeling for Treatment of Three Benign Epidermal Lesions

“…Our results were supported by Abdel-Daim et al [26] who stated that repetitive chemical peeling using 35% glycolic acid enhance apoptosis which in turn remove photodamaged keratinocytes.…”

Ingenol Mebutate Field-Directed Treatment of UVB-Damaged Skin Reduces Lesion Formation and Removes Mutant p53 Patches

“…Recently, chemical peels were also shown to reduce p53 patch numbers and lesion formation in chronically UVBirradiated mice (Abdel-Daim et al, 2010). However, this involved 10 treatments (1 treatment every 2 weeks), whereas a similar effect was achieved herein with only two ingenol mebutate treatments (once daily for 2 days).…”

Synergistic phototoxic effects of glycolic acid in a human keratinocyte cell line (HaCaT)

“…Furthermore, in animal model, Hong et al suggested inhibitory effect of GA (10.5%) on UVinduced skin tumorigenesis in SKH-1 hairless mice [14]. Preventive effect of GA (35%) on UV induced skin tumor formation was also investigated by Abdel-Daim et al [15]. However, the GA dose they used in animal model was higher than our in vitro study (10-35% vs. 0.038%) and the UV equipment they used in animal model was including UVA and UVB.…”

“…However, the GA dose they used in animal model was higher than our in vitro study (10-35% vs. 0.038%) and the UV equipment they used in animal model was including UVA and UVB. Hong et al applied GA topically twice a week at a dose of 8 mg/cm 2 (10.5%) in immediately after UV (including UVA and UVB) irradiation for 22 weeks [14] and AbdelDaim et al prescribed 35% GA at the back of UV (including UVA and UVB)-irradiated hairless mice every 2 weeks for about 18 weeks [15]. Our study demonstrated that GA had the synergistic phototoxicity may be related to cell cycle arrest and apoptosis in UVBtreated HaCaT cells.…”