Preventive effect of caffeine and curcumin on hepatoï¿½carcinogenesis in diethylnitrosamine-induced rats

Fujise, Yuki; Okano, Jun-ichi; Nagahara, Takakazu; Abe, Ryo; Imamoto, Ryu; Murawaki, Yoshikazu

doi:10.3892/ijo.2012.1343

Cited by 6 publications

(3 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the same study, despite not altering antiapoptotic Bcl-2 protein expression, caffeine administration increased the protein levels of proapoptotic Bax, whereas common caffeinated coffee did not . In line with these findings, caffeine showed similar results when administered alone, reducing GST-P-positive PNL and PCNA protein levels in the liver (Fujise et al, 2012) (Table 6, Figure 5). Chlorogenic acid administration alone attenuated the progression of HepG2 xenograft tumors in mice, reducing tumor volume and weight in a dose-dependent manner (Yan et al, 2017) (Table 6).…”

Section: Hepatocarcinogenesis Fibrosis/cirrhosis and Nafld Modelssupporting

confidence: 83%

Drinking for protection? Epidemiological and experimental evidence on the beneficial effects of coffee or major coffee compounds against gastrointestinal and liver carcinogenesis

Romualdo

Rocha

Vinken

et al. 2019

Food Research International

View full text Add to dashboard Cite

Recent meta-analysis indicate that coffee consumption may reduce the risk for digestive tract cancers (oral, esophageal, gastric and colorectal) and, especially, liver cancer. Coffee bean-derived beverages, such as the widely-consumed espresso and "common" filtered brews, are commodities of remarkable historical, cultural and economic importance globally. These drinks display rich and variable chemical composition, depending on many factors that vary from "seeding to serving". The alkaloids caffeine and trigonelline, and the polyphenol chlorogenic acid seem to be some of the most important bioactive organic compounds of these beverages, displaying high levels in both espresso and common brews and/or increased bioavailability after consumption. Thus, we proposed a comprehensive literature overview of current knowledge on the effects of coffee beverages and their highly bioavailable compounds, describing: 1) recent epidemiological and experimental findings highlighting the beneficial effects against gastrointestinal and liver carcinogenesis; and 2) the main molecular mechanisms in these in vitro and in vivo bioassays. Findings predominantly address protective effects of coffee and its most common and bioavailable compounds individually against gastrointestinal and liver cancer development. Our review underscores the complex effects of coffee on carcinogenesis, considering that beneficial effects are not limited to the whole beverage or selected compounds. Thus, this review should provide new insights of clinical and translational significance for further mechanistic investigations.

show abstract

Section: Hepatocarcinogenesis Fibrosis/cirrhosis and Nafld Modelssupporting

confidence: 83%

Drinking for protection? Epidemiological and experimental evidence on the beneficial effects of coffee or major coffee compounds against gastrointestinal and liver carcinogenesis

Romualdo

Rocha

Vinken

et al. 2019

Food Research International

View full text Add to dashboard Cite

show abstract

“…A similar study was also conducted by Fujise et al (2012) on rats with diethylonitrosoamine (DEN)--induced hepatocancerogenesis. This examined the effects of caffeine and curcumin on the alterations in liver function induced by DEN at weeks 10 and 14 of feeding.…”

Section: Studies On Laboratory Animalsmentioning

confidence: 98%

Coffee and nonalcoholic fatty liver disease: A review

Nikrandt

Chmurzyńska

2020

Acta Sci Pol Technol Aliment

View full text Add to dashboard Cite

Nonalcoholic fatty liver disease (NAFLD) is widely prevalent globally and has no effective treatment. Coffee is one of the most popular beverages in the world and can therefore have a significant impact on public health on account of its health-promoting properties. Evidence from observational, clinical, and animal studies suggests that coffee may play an important role in human health. This article summarizes the effects of coffee on liver health, especially on nonalcoholic fatty liver disease (NAFLD) and its progression: liver fibrosis, cirrhosis and hepatocellular carcinoma. In addition, this article describes the pathogenesis, prevalence, diagnosis, and nutrition guidelines relating to NAFLD. Possible mechanisms responsible for the effects of coffee on the liver are also suggested.

show abstract

“…Primary liver cancer is one of the most frequent malignant tumors, representing the fifth most common malignancy worldwide and the second leading cause of cancer deaths, with a 5-year survival rate of 17% (Fujise et al, 2016;Llovet et al, 2012). China has more than 55% liver cancer cases globally.…”

Section: Introductionmentioning

confidence: 99%

Chemoprevention of elite tea variety CFT‐1 rich in EGCG against chemically induced liver cancer in rats

Liao

Lin

Liu

et al. 2019

Food Science & Nutrition

View full text Add to dashboard Cite

Camellia sinensis (L.) O. Kuntze cv. CFT‐1 is an elite tea variety bred by sexual hybridization with a high content of epigallocatechin‐3‐gallate (EGCG) as 134.2 mg/g (which is 2.54‐fold that of the common variety). This study was to evaluate the chemopreventive effects of CFT‐1 green tea infusion (CFT‐1) against N ‐nitrosodiethylamine (NDEA)‐induced hepatocarcinogenesis in rats and its mechanisms. The results showed that CFT‐1 had a superior inhibitory effect in NDEA‐initiated hepatocarcinogenesis compared to that of common tea. CFT‐1 significantly reduced the hepatic nodules incidence, size, and number and prevented the hepatic adenoma or hepatocellular carcinoma (HCC) formation. In particular, CFT‐1‐treated animals had the least incidence of HCC (8.33%) followed by common tea treatment (40.00%) and model control rats (87.50%). CFT‐1 treatment significantly ameliorated abnormal liver function enzymes, reduced serum AFP, CEA, TSGF, and TNF‐α levels, inhibited the dickkopf‐related protein‐1 expression, enhanced antioxidant capacity, suppressed the production of livers 8‐hydroxy‐2′‐deoxyguanosine, and regulated hepatic phase I and II xenobiotic‐metabolizing enzymes. Transcriptomic analysis of liver tissue suggested that compared to common tea, administration of CFT‐1 regulated larger gene sets, which were located in several important pathways of antioxidants, inflammatory network, xenobiotic‐metabolizing enzymes, apoptosis, cell proliferation, and metabolism associated with liver tumorigenesis. We identified some genes as potential molecular targets involved in the prevention of CFT‐1 and found that CFT‐1 inhibited inflammation response, proliferation, and accelerated apoptosis by inhibiting NF‐κB and PI3K/Akt pathway. Thus, EGCG‐rich CFT‐1 green tea might be a potential choice for liver cancer prevention/treatment in the future.

show abstract

Preventive effect of caffeine and curcumin on hepatoï¿½carcinogenesis in diethylnitrosamine-induced rats

Cited by 6 publications

References 33 publications

Drinking for protection? Epidemiological and experimental evidence on the beneficial effects of coffee or major coffee compounds against gastrointestinal and liver carcinogenesis

Drinking for protection? Epidemiological and experimental evidence on the beneficial effects of coffee or major coffee compounds against gastrointestinal and liver carcinogenesis

Coffee and nonalcoholic fatty liver disease: A review

Chemoprevention of elite tea variety CFT‐1 rich in EGCG against chemically induced liver cancer in rats

Contact Info

Product

Resources

About