Preventive and Therapeutic Roles of Berberine in Gastrointestinal Cancers

Hu, Siwang; Zhao, Ruochi; Liu, Yahui; Chen, Junzheng; Zheng, Zhenzhen; Wang, Shuangshuang

doi:10.1155/2019/6831520

Cited by 32 publications

(13 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, CASC2 lncRNA binds to the Au-rich element-binding factor 1 (AUF1), which blocks the binding of AUF1 to Bcl-2 mRNA, thereby inactivating Bcl-2 translation [ 56 ]. There are many antitumor mechanisms induced by BBR in human colorectal cancer cells, such as suppression of cell viability, induction of cell apoptosis, and upregulation of CASC2 lncRNA [ 56 , 57 ]. Berberine also modulates the expression of the micro-RNA-429 (MIR-429) in colorectal cancer [ 58 ].…”

Section: Anticancer Perspectivesmentioning

confidence: 99%

Berberine as a Potential Anticancer Agent: A Comprehensive Review

et al. 2021

View full text Add to dashboard Cite

Berberine (BBR), a potential bioactive agent, has remarkable health benefits. A substantial amount of research has been conducted to date to establish the anticancer potential of BBR. The present review consolidates salient information concerning the promising anticancer activity of this compound. The therapeutic efficacy of BBR has been reported in several studies regarding colon, breast, pancreatic, liver, oral, bone, cutaneous, prostate, intestine, and thyroid cancers. BBR prevents cancer cell proliferation by inducing apoptosis and controlling the cell cycle as well as autophagy. BBR also hinders tumor cell invasion and metastasis by down-regulating metastasis-related proteins. Moreover, BBR is also beneficial in the early stages of cancer development by lowering epithelial–mesenchymal transition protein expression. Despite its significance as a potentially promising drug candidate, there are currently no pure berberine preparations approved to treat specific ailments. Hence, this review highlights our current comprehensive knowledge of sources, extraction methods, pharmacokinetic, and pharmacodynamic profiles of berberine, as well as the proposed mechanisms of action associated with its anticancer potential. The information presented here will help provide a baseline for researchers, scientists, and drug developers regarding the use of berberine as a promising candidate in treating different types of cancers.

show abstract

Section: Anticancer Perspectivesmentioning

confidence: 99%

Berberine as a Potential Anticancer Agent: A Comprehensive Review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Accordingly, the evidence from in vivo studies has confirmed that BBR exerts enormous therapeutic potential on various diseases, including cardiovascular diseases [27], metabolic diseases [28], inflammatory diseases [29] and cancers [30]. In terms of modern biomedical studies, the anti-cancer activities of BBR have been demonstrated, which were correlated to inhibit the proliferation, growth, and metastasis of tumors, including gastric cancer, pancreatic cancer, breast cancer, lung cancer, liver cancer and colorectal cancer [31]. Liu and colleagues found that BBR can inhibit the growth, migration/invasion of CRC cells via the COX-2/PGE2 mediated JAK2/STAT3 signaling pathway [32].…”

Section: Introductionmentioning

confidence: 99%

Pre-Administration of Berberine Exerts Chemopreventive Effects in AOM/DSS-Induced Colitis-Associated Carcinogenesis Mice via Modulating Inflammation and Intestinal Microbiota

et al. 2022

View full text Add to dashboard Cite

Inflammatory activation and intestinal flora imbalance play an essential role in the development and progression of colorectal cancer (CRC). Berberine (BBR) has attracted great attention in recent years due to its heath-related benefits in inflammatory disorders and tumors, but the intricate mechanisms have not been fully elucidated. In this study, the effects and the mechanism of BBR on colon cancer were investigated in an azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colitis-associated carcinogenesis mice model. Our results showed that pre-administration of BBR showed a decrease in weight loss, disease activity index (DAI) score, and the number of colon tumors in mice, compared with the model group. The evidence from pathological examination indicated that the malignancy of intestinal tumors was ameliorated after pre-administration of BBR. Additionally, pre-administration with BBR suppressed the expression of pro-inflammatory factors (interleukin (IL)-6, IL-1β, cyclooxygenase (COX)-2 and tumor necrosis factor (TNF)-α) and the cell-proliferation marker Ki67, while expression of the tight junction proteins (ZO-1 and occludin) were increased in colon tissue. Moreover, the levels of critical pathway proteins involved in the inflammatory process (p-STAT3 and p-JNK) and cell cycle regulation molecules (β-catenin, c-Myc and CylinD1) exhibited lower expression levels. Besides, 16S rRNA sequence analysis indicated that pre-administration of BBR increased the ratio of Firmicutes/Bacteroidetes (F:M) and the relative abundance of potentially beneficial bacteria, while the abundance of cancer-related bacteria was decreased. Gavage with Lactobacillus rhamnosus can improve the anti-tumor effect of BBR. Overall, pre-administration of BBR exerts preventive effects in colon carcinogenesis, and the mechanisms underlying these effects are correlated with the inhibition of inflammation and tumor proliferation and the maintenance of intestinal homeostasis.

show abstract

“…The therapeutic effect of berberine on depression has also been confirmed by numerous experiments. Studies have found that berberine can exert antidepressant effect by inhibiting neuroinflammation and regulating brain biogenic amines (Yin et al 2008 ; Hu et al 2019 ). What’s more, berberine can greatly shorten the immobility time of mice in FST and TST in animal experiments (Peng et al 2007 ; Lee et al 2012 ).…”

Section: Discussionmentioning

confidence: 99%

The effect and mechanism of Jiao-tai-wan in the treatment of diabetes mellitus with depression based on network pharmacology and experimental analysis

Tang

Wang

et al. 2021

Mol Med

View full text Add to dashboard Cite

Background The incidence of diabetes mellitus (DM) and depression is increasing year by year around the world, bringing a serious burden to patients and their families. Jiao-tai-wan (JTW), a well-known traditional Chinese medicine (TCM), has been approved to have hypoglycemic and antidepressant effects, respectively, but whether JTW has such dual effects and its potential mechanisms is still unknown. This study is to evaluate the dual therapeutic effects of JTW on chronic restraint stress (CRS)-induced DM combined with depression mice, and to explore the underlying mechanisms through network pharmacology. Methods CRS was used on db/db mice for 21 days to induce depression-like behaviors, so as to obtain the DM combined with depression mouse model. Mice were treated with 0.9% saline (0.1 ml/10 g), JTW (3.2 mg/kg) and Fluoxetine (2.0 mg/kg), respectively. The effect of JTW was accessed by measuring fasting blood glucose (FBG) levels, conducting behavioral tests and observing histopathological change. The ELISA assay was used to evaluate the levels of inflammatory cytokines and the UHPLC-MS/MS method was used to determine the depression-related neurotransmitters levels in serum. The mechanism exploration of JTW against DM and depression were performed via a network pharmacological method. Results The results of blood glucose measurement showed that JTW has a therapeutic effect on db/db mice. Behavioral tests and the levels of depression-related neurotransmitters proved that JTW can effectively ameliorate depression-like symptoms in mice induced by CRS. In addition, JTW can also improve the inflammatory state and reduce the number of apoptotic cells in the hippocampus. According to network pharmacology, 28 active compounds and 484 corresponding targets of JTW, 1407 DM targets and 1842 depression targets were collected by screening the databases, and a total of 117 targets were obtained after taking the intersection. JTW plays a role in reducing blood glucose level and antidepressant mainly through active compounds such as quercetin, styrene, cinnamic acid, ethyl cinnamate, (R)-Canadine, palmatine and berberine, etc., the key targets of its therapeutic effect include INS, AKT1, IL-6, VEGF-A, TNF and so on, mainly involved in HIF-1 signal pathway, pathways in cancer, Hepatitis B, TNF signal pathway, PI3K-Akt signal pathway and MAPK signaling pathway, etc. Conclusion Our experimental study showed that JTW has hypoglycemic and antidepressant effects. The possible mechanism was explored by network pharmacology, reflecting the characteristics of multi-component, multi-target and multi-pathway, which provides a theoretical basis for the experimental research and clinical application of JTW in the future.

show abstract

Preventive and Therapeutic Roles of Berberine in Gastrointestinal Cancers

Cited by 32 publications

References 63 publications

Berberine as a Potential Anticancer Agent: A Comprehensive Review

Berberine as a Potential Anticancer Agent: A Comprehensive Review

Pre-Administration of Berberine Exerts Chemopreventive Effects in AOM/DSS-Induced Colitis-Associated Carcinogenesis Mice via Modulating Inflammation and Intestinal Microbiota

The effect and mechanism of Jiao-tai-wan in the treatment of diabetes mellitus with depression based on network pharmacology and experimental analysis

Contact Info

Product

Resources

About