Preventive and therapeutic effects of natural products and herbal extracts on <scp>nonalcoholic fatty liver disease</scp>/<scp>nonalcoholic steatohepatitis</scp>

Cao, Yijun; Fang, Xiaoxue; Sun, Menghong; Zhang, Yegang; Shan, Mengyao; Lan, Xintian; Zhu, Difu; Luo, Haoming

doi:10.1002/ptr.7932

Cited by 8 publications

(4 citation statements)

References 283 publications

(307 reference statements)

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“…In recent years, multiple studies have indicated that a combination of traditional Chinese and Western medicine in treating NAFLD is more effective than Western medicine alone in improving abnormal liver function, reducing blood lipids, and enhancing insulin resistance, among other aspects. [ 10 , 11 ] Based on this, our study includes randomized controlled trials of traditional Chinese medicine in combination with Silymarin capsules for the treatment of NAFLD in accordance with the standards. We intend to use meta-analysis and systematic evaluation to explore the clinical efficacy and quality assessment of traditional Chinese medicine in combination with Silymarin in the treatment of NAFLD.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of traditional Chinese medicine combined with Silibinin on nonalcoholic fatty liver disease: A meta-analysis and systematic review

Zhang,

Jiang,

Jin

et al. 2024

Medicine

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Background: The efficacy and safety of traditional Chinese medicine (TCM) combined with Silibinin in the treatment of nonalcoholic fatty liver disease (NAFLD) are still inconclusive. This meta-analysis intends to evaluation to explore the clinical efficacy and quality assessment of traditional Chinese medicine in combination with Silymarin in the treatment of NAFLD, aiming to aims to provide evidence-based data analysis for researchers and clinical practitioners involved in TCM research for NAFLD, with the hope of facilitating wider adoption and application Methods: In this meta-analysis, we searched PubMed, Embase, Cochrane Library, CNKI, Wanfang, CQVIP and CBM databases from the establishment of the databases to Oct 2023. The study proposed to include studies that reported combination of TCM with Silibinin and Silibinin alone in the treatment of NAFLD, excluding studies for which full text was not available or for which data extraction was not possible; studies using animal studies; reviews and systematic reviews. All data were processed by STATA15.1 statistical software. Results: 16 randomized controlled trials (RCTs) were included in this meta-analysis. The sample size ranged from 48 to 120, with a total of 1335 patients, including 669 in the Combined treatment group and 384 in the Silibinin group. The findings indicated that the total effective rate of combined treatment group was significantly higher than that of Silibinin alone. Levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), triglycerides (TG), and gamma glutamyl transpeptidase (GGT) of combined treatment group were all significantly lower than that of western medicine alone. Additionally, after treating NAFLD with a combination of TCM and Silibinin, the TCM syndrome score were significantly lower than those observed with Silibinin alone. Conclusion: Traditional Chinese medicine in conjunction with Silibinin capsules has shown significant efficacy in the treatment of NAFLD, improving clinical symptoms, blood lipid levels, and liver function. Furthermore, it is essential to engage in multi-omics research, investigate iron death, and explore the gut microbiota as potential observational indicators for the diagnosis and inclusion criteria. Conducting more high-quality clinical experiments is necessary to further validate these findings.

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Section: Introductionmentioning

confidence: 99%

Efficacy of traditional Chinese medicine combined with Silibinin on nonalcoholic fatty liver disease: A meta-analysis and systematic review

Zhang,

Jiang,

Jin

et al. 2024

Medicine

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“…20,21 Flavonoids are plentiful in diverse natural sources and have been documented to yield considerable therapeutic benefits in NAFLD by engaging multiple pathways. 22 Mechanistic research demonstrated that flavonoids present in snow chrysanthemum targeted the Sirt1/PPARγ pathway to regulate hepatic glucose and lipid metabolism. 23 Another research showed that the flavonoids present in Eucommia ulmoides leaves could potentially decrease lipid levels by regulating PPARγ expression via induction of autophagy.…”

Section: Introductionmentioning

confidence: 99%

Integration of network pharmacology, lipidomics, and transcriptomics analysis to reveal the mechanisms underlying the amelioration of AKT-induced nonalcoholic fatty liver disease by total flavonoids in vine tea

Du,

Chen,

Ren

et al. 2024

Food Funct.

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“…At present, many natural products have been found to have the effect of regulating the intestinal liver axis and improving fatty liver. These natural products are mainly effective by affecting intestinal microbiota, bile acid metabolism, inflammatory reactions and other ways ( Cao et al, 2023 ). This article presents a comprehensive review of how metabolites derived from natural products influence the gut microbiota composition.…”

Section: Introductionmentioning

confidence: 99%

The gut-liver axis in fatty liver disease: role played by natural products

Ming,

Ruishi,

Linyi

et al. 2024

Front. Pharmacol.

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Fatty liver disease, a condition characterized by fatty degeneration of the liver, mainly classified as non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD), has become a leading cause of cirrhosis, liver cancer and death. The gut-liver axis is the bidirectional relationship between the gut and its microbiota and its liver. The liver can communicate with the gut through the bile ducts, while the portal vein transports the products of the gut flora to the liver. The intestinal flora and its metabolites directly and indirectly regulate hepatic gene expression, leading to an imbalance in the gut-liver axis and thus contributing to the development of liver disease. Utilizing natural products for the prevention and treatment of various metabolic diseases is a prevalent practice, and it is anticipated to represent the forthcoming trend in the development of drugs for combating NAFLD/ALD. This paper discusses the mechanism of the enterohepatic axis in fatty liver, summarizes the important role of plant metabolites in natural products in fatty liver treatment by regulating the enterohepatic axis, and provides a theoretical basis for the subsequent development of new drugs and clinical research.

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Preventive and therapeutic effects of natural products and herbal extracts on nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

Cited by 8 publications

References 283 publications

Efficacy of traditional Chinese medicine combined with Silibinin on nonalcoholic fatty liver disease: A meta-analysis and systematic review

Efficacy of traditional Chinese medicine combined with Silibinin on nonalcoholic fatty liver disease: A meta-analysis and systematic review

Integration of network pharmacology, lipidomics, and transcriptomics analysis to reveal the mechanisms underlying the amelioration of AKT-induced nonalcoholic fatty liver disease by total flavonoids in vine tea

The gut-liver axis in fatty liver disease: role played by natural products

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