Preventive and Therapeutic Effects of Polaprezinc Suspension on Oral Mucosal Injury

Ishihama, Hiromi; Sayo, S.; Yokoyama, Tetsuji; Ueno, Masashi; Ebihara, Nobuyuki; Doi, Yasufumi; Asano, Kimisato; Kawamata, Hitoshi; Imai, Hirotatsu; Ueki, Keisuke

doi:10.1093/annonc/mdt460.12

Cited by 3 publications

(3 citation statements)

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“…Ishihama et al reported that a ZnC mouth rinse was effective for improving oral mucosal injury in 423 patients who were experiencing symptoms of oral mucosal injury as a result of cancer treatment. Effects of the ZnC rinse were examined according to the cancer treatment method: The stomatitis prevention success rate, symptom improvement rate, pain prevention success rate, and symptom improvement rate were 68.5%, 84.4%, 75.4%, and 76.7%, respectively, for chemotherapy (n = 280); 32.7%, 64.5%, 45.5%, and 73.5% for chemoradiation therapy (n = 95); and 29.6%, 60.0%, 40.7%, and 68.6% for radiotherapy alone [25].…”

Section: Oral Mucositismentioning

confidence: 98%

“…While there are several studies reporting its efficacy in restoring the gastric lining [7], there is evidence to suggest it restores tissue in other parts of the GI tract as well. For example, there is research to support its role in the management of taste disorders [8][9][10], GI disorders [11][12][13][14][15][16][17], skin [18,19], liver [20,21], and oral mucositis resulting from chemo and or radiotherapy [22][23][24][25]. This makes sense considering that these soft wet tissues are all lined with epithelial tissues, and zinc plays a key role in maintaining the health and repair of epithelial tissue [3].…”

Section: Introductionmentioning

confidence: 99%

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A Review of Zinc-L-Carnosine and Its Positive Effects on Oral Mucositis, Taste Disorders, and Gastrointestinal Disorders

Hewlings

2020

Nutrients

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Zinc-L-carnosine (ZnC), also called polaprezinc known as PepZin GI™, is a chelated compound that contains L-carnosine and zinc. It is a relatively new molecule and has been associated with multiple health benefits. There are several studies that support ZnC’s benefits in restoring the gastric lining, healing other parts of the gastrointestinal (GI) tract, improving taste disorders, improving GI disorders, and enhancing skin and liver. Oral mucositis is a common complication of cytotoxic radiotherapy and/or chemotherapy. It occurs in almost every person with head and neck cancer who receive radiotherapy. It is often overlooked because it is not considered life threatening. However, mucositis often leads to a decreased quality of life and cessation of treatment, ultimately decreasing positive outcomes. Therefore, solutions to address it should be considered. The primary mechanisms of action are thought to be localized and related to ZnC’s anti-inflammatory and antioxidant functions. Therefore, the purpose of this review is to discuss the research related to ZnC and to explore its benefits, especially in the management of conditions related to damaged epithelial cells, such as oral mucositis. Evidence supports the safety and efficacy of ZnC for the maintenance, prevention, and treatment of the mucosal lining and other epithelial tissues. The research supports its use for gastric ulcers (approved in Japan) and conditions of the upper GI and suggests other applications, particularly for oral mucositis.

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Section: Oral Mucositismentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

A Review of Zinc-L-Carnosine and Its Positive Effects on Oral Mucositis, Taste Disorders, and Gastrointestinal Disorders

Hewlings

2020

Nutrients

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“…In patients with leukemia who received chemotherapy and radiotherapy and an allogeneic bone marrow stem cell transplant (40), the incidence of moderate to severe oral mucositis is significantly reduced in the polaprezinc-treated group compared with the control group (20 vs. 82%; P<0.01). Ishihama et al (41) reported that a polaprezinc mouth rinse effectively improves oral mucosal injury in 423 patients with symptoms of oral mucosal injury as a result of cancer treatment. The effects of the polaprezinc rinse were evaluated according to the cancer treatment method.…”

Section: Mucosal Damage Caused By Radiotherapy Oral Mucositismentioning

confidence: 99%

Recent advances on polaprezinc for medical use (Review)

Sun

Zhang

2021

Exp Ther Med

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The present study described the chemical and biological properties of zinc complex of L-carnosine (L-CAZ; generic name, polaprezinc; chemical name, catena-molecular formula, C 9 H 14 N 4 O 3 Zn; molecular weight, 291.6404; CAS registry number, 107667-60-7). Characterized as a white or yellowish white crystalline powder, this drug is insoluble in glacial acetic acid and almost insoluble in water, methanol, ethanol and ether. It is soluble in dilute hydrochloric acid, dilute nitric acid and sodium hydroxide solution, and its melting point is 260-270˚C. Polaprezinc is an anti-ulcer drug that was jointly studied and developed by Hamari Chemicals Co., Ltd. and Zeria Pharmaceutical Co., Ltd., and was first approved in Japan in 1994. This review article summarizes the research advances of polaprezinc, including the patents, preparations, synthetic routes, pharmacokinetics, pharmacological effects and application in clinical research. Contents 1. Introduction 2. Patents and preparations 3. Synthetic route and pharmacokinetics of polaprezinc 4. Pharmacological study of polaprezinc 5. Clinical uses of polaprezinc 6. Other clinical applications 7. Safety 8. Conclusion

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Zinc l-carnosine in gastric ulcers: a profile of its use

Lyseng‐Williamson

2019

Drugs Ther Perspect

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Preventive and Therapeutic Effects of Polaprezinc Suspension on Oral Mucosal Injury

Cited by 3 publications

References 0 publications

A Review of Zinc-L-Carnosine and Its Positive Effects on Oral Mucositis, Taste Disorders, and Gastrointestinal Disorders

A Review of Zinc-L-Carnosine and Its Positive Effects on Oral Mucositis, Taste Disorders, and Gastrointestinal Disorders

Recent advances on polaprezinc for medical use (Review)

Zinc l-carnosine in gastric ulcers: a profile of its use

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