Preventive and therapeutic effects of NF-kappaB inhibitor curcumin in rats colitis induced by trinitrobenzene sulfonic acid

Jian, Yan-Ting; Mai, Guo-feng; Wang, Jide; Zhang, Yali; Luo, Rong; Fang, Yong-xin

doi:10.3748/wjg.v11.i12.1747

Cited by 113 publications

(113 citation statements)

References 29 publications

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“…The molecular mechanism involved in the suppressive effects of Curcumin on NFκ-B could be due to the inhibition of NFκ-B by acting as antioxidants, since NFκ-B is a redox-sensitive transcription factor and activated by oxidative stress in the inflamed intestinal mucosa via blocking the phosphorylation and degradation of IkB protein, as previously reported in vitr o and in vivo [7,19] .…”

Section: Discussionmentioning

confidence: 86%

“…The results obtained in this study confirm the intestinal anti-inflammatory effect previously demonstrated for Curcumin [9,17] . Earlier studies provided evidence of significantly elevated activation of NFκ-B in ulcerative colitis and Crohn's disease [18,19] . Several therapeutic agents with NFκ-B inhibitory activity, such as sulfasalazine, mesalamine, and corticosteroids have been used for the treatment of IBD.…”

Section: Discussionmentioning

confidence: 99%

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NCB-02 (standardized Curcumin preparation) protects dinitrochlorobenzene-induced colitis through down-regulation of NFκ-B and iNOS

Venkataranganna¹,

Rafiq²,

Gopumadhavan³

et al. 2007

WJG

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at a dose of 100 mg/kg b.wt. inhibited the DNCB-induced overexpression of NFκ-B and iNOS in the colon. CONCLUSION:Curcumin treatment ameliorates colonic damage in DNCB-induced colitic rats, an effect associated with an improvement in intestinal oxidative stress and downregulation of colonic NFκ-B and iNOS expression. INTRODUCTIONInflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis (UC), is a chronic and relapsing inflammatory disease caused by the inflammation and sores in the lining of large intestine and characterized clinically by recurrent episodes of bloody diarrhea, cramping, abdominal pain and histologically by mucosal inflammation and injury [1] . Conventional therapy for UC includes sulfasalazine and other 5-aminosalicylic acid (5-ASA) type of compounds, and in more persistent and/ or severe cases, oral, rectal and parenteral corticosteroids and immunosuppressants are administered [2] . All of these have significant toxicities and are partly or completely ineffective in significant numbers of patients [3] . Several agents used in the management of IBD, such as corticosteroids, sulfasalazine and 5-ASA, have documented regulation of Nuclear Factor K appa-B (NF κ-B) function [2] . Given the importance of inflammatory cell activation involved in the development of IBD, there is a need for a treatment modality against IBD that can block the inflammatory processes. There is substantial evidence for the involvement of oxidative stress and profound alterations in the biosynthesis of the labile free Abstract AIM: To evaluate the efficacy and mechanism of action of NCB-02, a standardized Curcumin preparation, against 2, 4-dinitrochlorobenzene (DNCB)-induced ulcerative colitis in rats.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

NCB-02 (standardized Curcumin preparation) protects dinitrochlorobenzene-induced colitis through down-regulation of NFκ-B and iNOS

Venkataranganna¹,

Rafiq²,

Gopumadhavan³

et al. 2007

WJG

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“…The prophylactic Curcumin regimen (Group II) had a lower statistically significant muscle TAC value than the therapeutic regimen (Group III). Previous studies on other models of inflammation (murine colitis) reported the preventive and therapeutic effects of Curcumin (Jiang et al, 2006;Jian et al, 2005;Arafa et al, 2009). Research performed on human subjects concluded that short-term supplementation with bioavailable Curcumin significantly improves the inflammatory and oxidative status of patients, suggesting the benefits of prophylactic administration, with no toxicity risk (Menon and Sudheer, 2007).…”

Section: Discussionmentioning

confidence: 99%

Effect of Curcumin on Oxidative Stress in a Model of Turpentine Induced Acute Experimental Inflammation

Coneac

Orăsan

Leucuţa

et al. 2017

Not Bot Horti Agrobo

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Curcumin, a natural phenolic compound is an anti-tumor agent with anti-inflammatory and anti-oxidant properties. The aim of this research was to evaluate oxidative stress levels, the antioxidant activity and Curcumin concentrations by high performance liquid chromatography (HPLC) in an acute experimental inflammation induced by Turpentine oil (intramuscular 0.6 mg kg -1 body weight) and to compare a prophylactic versus a therapeutic regimen of Curcumin (oral suspension of 150 mg Curcumin kg -1 rat weight). Sixteen adult male Wistar rats were assigned to four groups: Control, Group I (Curcumin only), Group II (Curcumin administration, then induced inflammation after 1 hour) and Group III (induced inflammation then Curcumin administration after 2 hours). Oxidative stress was assessed by measuring serum malondialdehide and carbonylated proteins, while systemic and local total antioxidant capacity was determined by ABTS. Local tissue changes (muscle, kidney, liver) were analysed using histopathology. Results showed that acute inflammation significantly increased lipid peroxidation in Groups II and III compared to Control and Group I. A significantly reduced total antioxidant capacity (ATBS) was present in serum and kidney in Group II, also in muscle and kidney in Group III. ABTS levels were significantly increased only in the liver tissue of the animals in Groups II and III with induced inflammation as compared to Group I. This study proved the potential of Curcumin in reducing oxidative stress in both prophylactic and therapeutic regimens.

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“…In numerous experimental murine models of colitis, there is evidence that curcumin has potential therapeutic and preventive benefits that may be applicable in the treatment of IBD 8,14,19 . Previously, using the human intestinal cell line (HCT116, HT-29 and CaCO 2 ), it was shown that curcumin pretreatment inhibited and modulated gene expression of IL-8 in response to inflammatory cytokine exposure 20,21 .…”

Section: Discussionmentioning

confidence: 99%

“…In inflammatory bowel disease (IBD), curcumin is proposed as an attractive alternative therapy to the conventional medicines 5,6 . Curcumin is considered to be safe and inexpensive 7 and emerging evidence from pre-clinical studies indicates the potential benefits of curcumin supplementation in IBD [8][9][10][11] . Clinical trials of curcumin have included a pilot study involving 5 patients with chronic ulcerative proctitis and 5 patients with Crohn's disease (CD) 12 .…”

Section: Introductionmentioning

confidence: 99%

Defining the therapeutic and preventative anti-inflammatory benefits of curcumin in vitro

Alhagamhmad¹,

Lemberg²,

Day³

et al. 2013

OA Inflammation

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IntroductionIn the setting of inflammatory bowel disease, curcumin supplementation to prevent inflammatory flares has shown promise. However, the outcome of curcumin exposure, when there is existing inflammation, is not clear. The aim of this study was to compare the anti-inflammatory properties of curcumin when added at differing times to an inflammatory stimulus, in an established in vitro intestinal epithelial cell model of intestinal inflammation. Materials and MethodsHT-29 and INT407 cells were incubated with a range of concentrations of curcumin prior to, or at the same time as, the addition of tumour necrosis factor-α. Following incubation, cell viability, interleukin-8 levels and cytoplasmic inhibitor of kappa B (IκB) were assessed. Results High concentrations of curcumin reduced epithelial cell viability. At lower concentrations, curcumin had no effect on cell viability; however, curcumin (with or without pre-incubation) reduced interleukin-8 levels and inhibited the phosphorylation and degradation of IκB. Conclusion Curcumin can reduce interleukin-8 and IκB response to tumour necro-

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Preventive and therapeutic effects of NF-kappaB inhibitor curcumin in rats colitis induced by trinitrobenzene sulfonic acid

Abstract: This study shows that NF-kappaB inhibitor curcumin could prevent and improve experimental colitis in murine model with inflammatory bowel disease (IBD). The findings suggest that NF-kappaB inhibitor curcumin could be a potential target for the patients with IBD.

Cited by 113 publications

References 29 publications

NCB-02 (standardized Curcumin preparation) protects dinitrochlorobenzene-induced colitis through down-regulation of NFκ-B and iNOS

NCB-02 (standardized Curcumin preparation) protects dinitrochlorobenzene-induced colitis through down-regulation of NFκ-B and iNOS

Effect of Curcumin on Oxidative Stress in a Model of Turpentine Induced Acute Experimental Inflammation

Defining the therapeutic and preventative anti-inflammatory benefits of curcumin in vitro

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