Preventive and therapeutic effect of treadmill running on chronic stress-induced memory deficit in rats

Radahmadi, Maryam; Alaei, Hojjatallah; Sharifi, Mohammad Reza; Hosseini, Nasrin

doi:10.1016/j.jbmt.2014.04.007

Cited by 18 publications

(16 citation statements)

References 53 publications

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“…In our previous studies, memory was evaluated by the passive avoidance test in the preventive, therapeutic, and protective exercise groups (4,6). The findings of the present study did not indicate any significant correlations between the hippocampal CORT, BDNF, IL-1ß, and glucose levels separately with memory in all of the experimental groups (not presented here as a graph).…”

Section: Correlations Between the Behavioral Test And The Biochemicalcontrasting

confidence: 46%

“…These studies have confirmed that different exercise protocols ameliorate cognitive and memory function (4)(5)(6). Accordingly, exercise could alter brain functions in the stressful conditions and neurodegenerative diseases (4)(5)(6)(7)(8)(9). It is demonstrated that stress and exercise affect the secretion of glucocorticoids hormones (corticosterone in rats; CORT) from the adrenal glands (2,(10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 73%

“…In our previous studies, memory was assessed in the preventive, therapeutic, and protective exercise groups by passive avoidance test (4,6). In these studies, memory functions at the end of the experimental period did not show any significant differences in the preventive and the protective exercise groups (5,6).…”

Section: Discussionmentioning

confidence: 93%

“…According to our previous studies, the impairment of memory processes has been demonstrated by using chronic stress (2,3). Based on our other previous documents, exercise can be regarded as a beneficial manner in the improvement of learning and memory in stress conditions and even Alzheimer disease (4)(5)(6)(7)(8). These studies have confirmed that different exercise protocols ameliorate cognitive and memory function (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

“…Based on our other previous documents, exercise can be regarded as a beneficial manner in the improvement of learning and memory in stress conditions and even Alzheimer disease (4)(5)(6)(7)(8). These studies have confirmed that different exercise protocols ameliorate cognitive and memory function (4)(5)(6). Accordingly, exercise could alter brain functions in the stressful conditions and neurodegenerative diseases (4)(5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Preventive, Therapeutic and Protective Exercises on Hippocampal memory Mediators in Stressed Rats

Radahmadi

Hosseini

Alaei

et al. 2016

MJMS

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Methods: Fortymaleratswererandomlydividedintofourgroups:thecontrolgroupand thepreventive,therapeutic,andprotectiveexercisegroups.Thetreadmillrunningwasappliedat aspeedof20-21m/minandachronicstressof6hours/dayfor21days.Subsequently,thevariables weremeasuredinthehippocampus.Results: The findings revealed that the hippocampal CORT levels in the preventive exercise group had a significant enhancement compared to the control group. In the protective and particularly the therapeutic exercise groups, the hippocampal CORT levels declined. Furthermore,thehippocampalBDNFlevelsinthepreventiveandthetherapeuticexercisegroups indicated significantly decreased and increased, respectively, in comparison with the control group.Inthepreventiveexercisegroup,however,thehippocampalglucoselevelturnedouttobe substantiallyhigherthanthatinthecontrolgroup.Conclusion: Itappearsthatthetherapeuticexercisegrouphadthebestexerciseprotocols for improving the hippocampal memory mediators in the stress conditions. By contrast, the preventive exercise group could not improve these mediators that had been altered by stress. It is suggested that exercise time, compared to stress, can be considered as a crucial factor in the responsivenessofmemorymediators.

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Section: Correlations Between the Behavioral Test And The Biochemicalcontrasting

confidence: 46%

Section: Introductionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Effect of Preventive, Therapeutic and Protective Exercises on Hippocampal memory Mediators in Stressed Rats

Radahmadi

Hosseini

Alaei

et al. 2016

MJMS

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The protective effects of escitalopram on synaptic plasticity in the CA1 region of chronically stressed and non‐stressed male rats

Farahbakhsh

Radahmadi

2022

Intl J of Devlp Neuroscience

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Introduction Stress impairs cognitive processes and escitalopram affects them in various ways. The present study has compared the protective effects of two escitalopram doses on neural excitability and synaptic plasticity in the CA1 region of chronically stressed and non‐stressed male rats. Methods Forty‐nine rats were randomly allocated into seven groups: Control (Co), stress (St), sham (Sh), escitalopram 10 and 20 mg/kg (Esc10 and Esc20), and stress‐escitalopram 10 and 20 mg/kg (St‐Esc10 and St‐Esc20). Induction of restraint stress (6 h/day) and escitalopram injections were performed for 14 days. The fEPSP slope and amplitude were measured according to input–output functions and after the LTP induction in the hippocampal CA1 region. Also, serum corticosterone levels were evaluated in all experimental groups. Results The fEPSP slope and amplitude decreased significantly in the St group and increased significantly in the Esc10 group compared with the Co group. In non‐stressed states, significant increases in slope and amplitude occurred in the Esc10 group compared with the Esc20 group. Notably, these values were also significantly enhanced by both escitalopram doses under stressed conditions. Moreover, serum corticosterone levels significantly elevated in the St group although its levels decreased in both St‐Esc groups compared with the St. Conclusion Stress significantly attenuated neural excitability and long‐term plasticity in the CA1 area. Only escitalopram 10 mg/kg improved synaptic excitability, as well as LTP induction and maintenance in non‐stressed subjects even more than normal levels. However, under stress conditions, both escitalopram doses enhanced neural excitability and memory probably due to reduced serum corticosterone levels.

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Does Stress Trigger Seizures? Evidence from Experimental Models

Reddy

Thompson

Calderara

2020

Psychiatric and Behavioral Aspects of Epilepsy

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Preventive and therapeutic effect of treadmill running on chronic stress-induced memory deficit in rats

Cited by 18 publications

References 53 publications

The Effect of Preventive, Therapeutic and Protective Exercises on Hippocampal memory Mediators in Stressed Rats

The Effect of Preventive, Therapeutic and Protective Exercises on Hippocampal memory Mediators in Stressed Rats

The protective effects of escitalopram on synaptic plasticity in the CA1 region of chronically stressed and non‐stressed male rats

Does Stress Trigger Seizures? Evidence from Experimental Models

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