Preventive analgesia with pregabalin in laparoscopic cholecystectomy post-operated patients

Trujillo-Esteves, Celina; Mayoral-Flores, Nadia Helena; Soto-Rivera, Bernardo; Rosas-Barrientos, José Vicente

doi:10.24875/gmm.m19000283

Cited by 3 publications

(4 citation statements)

References 11 publications

(18 reference statements)

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“…12 Other post-operative complications were also noted in a study by Kohli et al and they concluded that pre-operative administration of single dose pregabalin was associated with reduced blood pressure, heartrate and anxiety level. 11 In our study only two patients complained of postoperative nausea and vomiting (PONV), both from the placebo group, this could partly be explained by the fact that control group had lower consumption of rescue analgesia as compared to the placebo group and partly by the anti-emetic effect of pregabalin as reported in previous studies. [13][14][15][16] But the results regarding PONV in our study are inconclusive as the sample size of our study was small.…”

Section: Discussionsupporting

confidence: 59%

“…The consensus still lacks regarding the dose and duration of preventive analgesia to get the maximum benefit with minimal side effects but a linear relation has been observed between the increasing dose of pregabalin and reduction in pain scores. 11 One meta-analysis by David L et al found that pregabalin not only reduced post-operative pain but also decreased opioid consumption and their side effects such as sedation, constipation, respiratory depression, urinary retention and vomiting. 12 Other post-operative complications were also noted in a study by Kohli et al and they concluded that pre-operative administration of single dose pregabalin was associated with reduced blood pressure, heartrate and anxiety level.…”

Section: Discussionmentioning

confidence: 99%

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Preventive analgesia with oral tramadol and pregabalin for post-operative pain in breast surgical patients

Usman,

Mehdi,

Khan

2024

Anaesth. pain intensive care

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Background & objective: Preventive analgesia is implied before the actual surgical insult occurs and it is aimed to reduce the neuro-humoral changes associated with surgical induced pain. Different methods have been used by the anesthesiologists for this purpose. We studied the effect of pre-emptive oral tramadol 50 mg and pregabalin 100 mg on post-operative pain, the requirement of rescue analgesics and the stay in post-anesthesia care unit (PACU) in breast cancer surgery patients. Methodology: A randomized double blinded, placebo-controlled trial, was conducted in the Department of Anesthesia, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore (Pakistan) after ethical approval by the hospital Scientific Review Committee and Institutional Review Board. Atotal of 30 patients, undergoing breast cancer surgery, were enrolled and randomly divided into two groups. Group A (study group) patients were given tramadol 50 mg and pregabalin 100 mg orally, and Group B (control group) received two soda mint tablets orally 30 min prior to induction of anesthesia. Standard monitoring was done and routine general anesthesia was administered with intubation. After recovery, Visual Analog Scale (VAS) scores and time to rescue analgesia, total morphine consumption, were recorded. Data was analyzed using SPSS v.20. P < 0.05 was considered significant. Results: The mean ages in Group A and B were 36.67 ± 9.50 y and 41.80 ± 12.43 y (P = 0.236). The differences in intra-operative morphine and rescue morphine use in both groups were not significant (P = 0.139 and 0.293, The rescue analgesic use and VAS scores in PACU were significantly different in both groups (P = 0.005 and P = 0.022, respectively). Total PACU stay in Group A was 79.33 ± 26.31 min and in Group B was 96.67 ± 34.98 min (P = 0.281). Tramadol use in the ward was not statistically equivalent (P = 0.300). Mean post-operative rescue morphine was 0.2 ± 0.775 mg/kg in control group as compared to placebo group was 1.4 ± 1.682 mg/kg, which was statistically significant (P = 0.02). VAS scores in PACU in both groups showed statistically differences, e.g., 1.33 ± 1.1 vs 2.70 ± 1.60 (P = 0.01). PACU stay time was also higher in the control group. Conclusion: The use of pre-emptive analgesia with oral tramadol 50 mg and pregabalin 100 mg 30 min before the surgery can reduce the requirement of peri operative opioid use, achieve better pain control and early recovery. Abbreviations: BMI- Basal Metabolic Rate; PACU- Post-Anesthesia Care Unit; PONV- Postoperative Nausea and Vomiting; VAS- Visual Analog Scale Key words: Analgesia, Preventive; Cancer Surgery; Opioids; Post-Anesthesia Care Unit; Pregabalin; Tramadol Citation: Usman A, Mehdi SR, Khan AA. Preventive analgesia with oral tramadol and pregabalin for post-operative pain in breast surgical patients. Anaesth. pain intensive care 2024;28(1):81−84; DOI: 10.35975/apic.v28i1.2374 Received: November 17, 2021; Reviewed: September 24, 2022; Accepted: July 06, 2023

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Preventive analgesia with oral tramadol and pregabalin for post-operative pain in breast surgical patients

Usman,

Mehdi,

Khan

2024

Anaesth. pain intensive care

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“…Hence, reducing preoperative anxiety can improve perioperative functional ability and postoperative self-care ability [36]. Some studies have found that pregabalin can be used in patients before LC, which can not only reduce the preoperative anxiety level but also signi cantly reduce postoperative pain through the preemptive analgesia effect [37]. Moreover, anxiolytic medications like melatonin and midazolam can help patients relieve their anxiety before surgery.…”

Section: Discussionmentioning

confidence: 99%

The correlation between preoperative anxiety and postoperative pain in patients undergoing laparoscopic cholecystectomy

Gao,

Zhang,

Sun

et al. 2024

Preprint

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Objective: The effect of psychological factors on postoperative pain are often ignored in patients underwent surgery. Hence, this study aimed to explore the correlation between preoperative anxiety and postoperative pain of patients underwent laparoscopic cholecystectomy (LC). Methods: Patients underwent LC in West Chian Hospital from September 2022 and July 2023 were included. During the preoperative interview, the preoperative anxiety was evaluated by State Anxiety Inventory (S-AI); postoperative pain was evaluated by Visual Analog Scale (VAS) 1 h, 4–6 h and 24 h after surgery; postoperative recovery was assessed by Activity of Daily Living [1] scale at 4-6h and 24h after surgery; postoperative chronic pain was evaluated 3 months after surgery. Results: A total of 260 patients were included in this study, including 211 patients in the low-anxiety group and 49 patients in the high-anxiety group. VAS score in high-anxiety group was significantly higher than low-anxiety group at 1 h, 4–6 h and 24 h after surgery (P < 0.05), and S-AI score was positively correlated with the VAS score at each time point. Meanwhile, the incidence of chronic pain in high-anxiety group (24.5%) was higher than that in low-anxiety group (20.4%). A higher S-AI score was associated with a lower ADL score at 4–6 h and 24 h after surgery, while patients in the two groups consumed comparable doses of analgesics. Conclusion: Patients with high preoperative anxiety tended to have a high risk of severe acute pain and a high incidence of chronic pain after LC.

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“…Medical practitioners have advised and used various techniques to minimize this, like preoperative administration of opioids or opioid-sparring analgesia, clonidine, preoperative pregabalin, wound site instillation of local anesthetics, and intraperitoneal irrigation with bupivacaine or ondansetron and suctioning of residual gas from the peritoneum before closure [3][4][5][6][7][8][9][10]. 1 2…”

Section: Introductionmentioning

confidence: 99%

The Effect of Dexamethasone on Postoperative Pain in Patients After Laparoscopic Cholecystectomy

Jamil¹,

Qaisar²

2022

Cureus

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The objective of the study was to determine the effect of a single dose of IV dexamethasone on postoperative pain in patients after laparoscopic cholecystectomy. The outcome will be measured in the terms of mean pain score. Study design and settingThis is a prospective study. We did a randomized control trial to compare the outcome in two groups. This study was conducted in the Department of Surgery, Benazir Bhutto Hospital, Rawalpindi, from December 2021 to May 2022. The total duration of the study was six months. MethodologyA total of 160 patients were randomly divided into group A and group B. We performed laparoscopic cholecystectomies on all the patients under standard general anesthesia. In group A (control group), 5 mL of normal saline was injected intravenously at the time of induction of anesthesia. In group B, the dexamethasone group, the inj. dexamethasone with a dose of 0.1 mg/kg diluted in 5 mL normal saline was given intravenously at the time of induction of anesthesia. Postoperatively, the median pain score was measured using visual analog scale (VAS) at 2, 6, 12, and 24 h on a specially made proforma. The results were further stratified according to gender and age. ResultsThe postoperative VAS in group B was significantly low compared with group A when measured at 2, 6, 12, and 24 h. It means that the median pain score was markedly less in the study group than in the placebo one, and it was statistically significant (p<0.05). ConclusionAdministration of a single dose of dexamethasone preoperatively in laparoscopic cholecystectomy patients is effective to control postoperative pain.

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Preventive analgesia with pregabalin in laparoscopic cholecystectomy post-operated patients

Abstract: A controlled, blinded, balanced-block randomized clinical trial was carried out in a sample of 60 patients. According to sample size calculation by proportion estimation, 26 patients were required per group, and

Cited by 3 publications

References 11 publications

Preventive analgesia with oral tramadol and pregabalin for post-operative pain in breast surgical patients

Preventive analgesia with oral tramadol and pregabalin for post-operative pain in breast surgical patients

The correlation between preoperative anxiety and postoperative pain in patients undergoing laparoscopic cholecystectomy

The Effect of Dexamethasone on Postoperative Pain in Patients After Laparoscopic Cholecystectomy

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