Prevention Strategies Against HIV Transmission: A Proactive Approach

Carrion, Antonio J.; Miles, Jovan D.; Mosley, Juan F.; Smith, Lillian L.; Prather, April S.; Gurley, Marcus M.; Phan, Linh D.; Everton, Emily

doi:10.1177/0897190017696946

Cited by 4 publications

(1 citation statement)

References 20 publications

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“… 3 When initiated within 72 h of exposure, HIV-PEP may reduce the risk of HIV transmission by up to 85%. 4 However, if the time elapsed since exposure exceeds 72 h, the start of HIV-PEP is generally not recommended. 5 The prevalence rate of people living with HIV/acquired immunodeficiency syndrome (AIDS) among the adult German population has been estimated at 0.1%.…”

Section: Introductionmentioning

confidence: 99%

Concordance of emergency department physicians’ decisions on HIV post-exposure prophylaxis with national guidelines: results from a retrospective cohort study

Heck,

Höner zu Siederdissen,

Krause

et al. 2023

International Health

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Background Post-exposure prophylaxis (PEP) is an effective tool to prevent infection with HIV. Patients seeking PEP after potential HIV exposure usually present to the emergency department (ED). Our study sought to determine the concordance of ED physicians’ decisions on HIV-PEP with national guidelines (primary objective) and to assess the clinical relevance of drug–drug interactions (DDIs) between the HIV-PEP regimen and patients’ concomitant medication (secondary objective). Methods We conducted a retrospective cohort study at the ED of Hannover Medical School, Germany. Between 1 January 2018 and 31 December 2019, 113 of 11 246 screened patients presented to the ED after potential HIV exposure and were enrolled in the study. Results The median age of the patients (82.3% male) was 30 y (IQR 25–35.5), 85.8% of potential HIV exposures were characterised as sexual and 85.0% presented within 72 h. ED physicians’ decisions on HIV-PEP were concordant with national guidelines in 93.8%. No clinically relevant DDIs were detected. Conclusions ED physicians’ decisions on HIV-PEP were highly concordant with national guidelines. Approximately 1% of patient presentations to the ED were related to HIV exposure; therefore, training ED physicians on HIV transmission risk assessment and indications/contraindications for HIV-PEP is paramount.

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Section: Introductionmentioning

confidence: 99%