Prevention of unpredictable chronic stress-related phenomena in zebrafish exposed to bromazepam, fluoxetine and nortriptyline

Marcon, Matheus; Herrmann, Ana Paula; Mocelin, Ricieri; Rambo, Cassiano L.; Koakoski, Gessi; Abreu, Murilo S. de; Conterato, Greicy M. M.; Kist, Luiza Wilges; Bogo, Maurı́cio Reis; Zanatta, Leïla; Barcellos, Leonardo José Gil; Piato, Ângelo

doi:10.1007/s00213-016-4408-5

Cited by 90 publications

(75 citation statements)

References 76 publications

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“…FLU has been shown to blunt the cortisol response (Abreu et al, 2014) and, as a consequence, prevent stress-related osmoregulation changes in zebrafish (Abreu et al, 2015). In addition, fluoxetine reverses the anxiogenic effects of acute (Giacomini et al, 2016) and chronic (Marcon et al, 2016) stress in this species.…”

Section: Introductionmentioning

confidence: 87%

Divergent effect of fluoxetine on the response to physical or chemical stressors in zebrafish

Abreu

Giacomini

Koakoski

et al. 2017

PeerJ

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Fluoxetine is a selective serotonin reuptake inhibitor that increases serotonin concentration in the central nervous system and modulates various systems, including the control of sympathetic outflow and the hypothalamus-pituitaryadrenal. However, it is not yet established whether fluoxetine can modulate the responses to stressors stimulants (physical or chemical) that trigger cortisol response in zebrafish. We demonstrate that fluoxetine blunts the response to physical stress, but not to chemical stress.

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Section: Introductionmentioning

confidence: 87%

Divergent effect of fluoxetine on the response to physical or chemical stressors in zebrafish

Abreu

Giacomini

Koakoski

et al. 2017

PeerJ

Self Cite

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“…In the light–dark test, the preference for a black compartment over a white one, associated with risk assessment behaviours, erratic swimming, thigmotaxis and freezing is interpreted as defensive behaviour (Maximino et al ., ). Moreover, a relationship between stress and behaviour in these tests is established, as both acute (Giacomini et al ., ) and chronic (Chakravarty et al ., ; Marcon et al ., ) stress increases defensive behaviour in these assays and exposure to the apparatuses induce cortisol levels (Kysil et al ., ). A causal link between neuroendocrine and behavioural responses to stress has not been ascertained; since these are modulated by monoamines, these neurotransmitters could link both functions.…”

Section: The Aversive Behaviour Network Of Fishes: Modulation By 5‐htmentioning

confidence: 99%

The integration of sociality, monoamines and stress neuroendocrinology in fish models: applications in the neurosciences

Soares

Maximino

2018

Journal of Fish Biology

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Animal-focused research has been crucial for scientific advancement, but rodents are still taking a starring role. Starting as merely supporting evidence found in rodents, the use of fish models has slowly taken a more central role and expanded its overall contributions in areas such as social sciences, evolution, physiology and recently in translational medical research. In the neurosciences, zebrafish Danio rerio have been widely adopted, contributing to our understanding of the genetic control of brain processes and the effects of pharmacological manipulations. However, discussion continues regarding the paradox of function versus structure, when fishes and mammals are compared and on the potentially evolutionarily conserved nature of behaviour across fish species. From a behavioural standpoint, we explore aversive-stress and social behaviour in selected fish models and refer to the extensive contributions of stress and monoaminergic systems. We suggest that, in spite of marked neuroanatomical differences between fishes and mammals, stress and sociality are conserved at the behavioural and molecular levels. We also suggest that stress and sociality are mediated by monoamines in predictable and non-trivial ways and that monoamines could bridge the relationship between stress and social behaviour. To reconcile the level of divergence with the level of similarity, we need neuroanatomical, pharmacological, behavioural and ecological studies conducted in the laboratory and in nature. These areas need to add to each other to enhance our understanding of fish behaviour and ultimately how this all may lead to better model systems for translational studies.

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“…In the light/dark test, the preference for a black compartment over a white one, associated with risk assessment behaviours, erratic swimming, thigmotaxis, and freezing is interpreted as defensive behaviour (Maximino et al, 2010b). Moreover, a relationship between stress and behaviour in these tests is established, as both acute (Giacomini et al, 2016) and chronic (Chakravarty et al, 2013;Marcon et al, 2016) stress increases defensive behaviour in these assays, and exposure to the apparatuses induce cortisol levels (Kysil et al, 2017). A causal link between neuroendocrine and behavioural responses to stress has not been ascertained; since these are modulated by monoamines, these neurotransmitters could link both functions.…”

Section: Monoaminergic Innervation In Teleostsmentioning

confidence: 99%

The Integration of Sociality, Monoamines, and Stress Neuroendocrinology in Fish Models: Applications in the Neurosciences

Soares

Maximino

2018

Preprint

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Animal-focused research has been crucial for scientific advancement however, in this matter, rodents are still taking a starring role. Coming out from merely being supportive of evidence found in rodents, the use of fish models has slowly taken a more central role and expanded its overall contributions in areas such as social sciences, evolution, physiology, and recently in translational medical research. In neurosciences, zebrafish has been widely adopted, contributing to our understanding of the genetic control of brain processes, and the effects of pharmacological manipulations. However, discussion continues regarding the paradox of function versus structure, when fish and mammals are compared, and on the potentially evolutionarily conserved nature of behaviour across fish species. From the behavioural stand point we explored aversive/stress and social behaviour in selected fish models, and refer to the extensive contributions of stress and monoaminergic systems. We suggest that, in spite of marked neuroanatomical differences between fish and mammals, stress and sociality are conserved at the behavioural and molecular levels. We also suggest that stress and sociality are mediated by monoamines in predictable and non-trivial ways, and that monoamines could "bridge" the relationship between stress and social behaviour. To reconcile the level of divergence with the level of similarity, we need neuroanatomical, pharmacological, behavioural, and ecological studies conducted in the laboratory and in nature.These areas need to add to each other to enhance our understanding of fish behaviour and ultimately how this all may translate to better model systems for translational studies.

show abstract

Prevention of unpredictable chronic stress-related phenomena in zebrafish exposed to bromazepam, fluoxetine and nortriptyline

Abstract: This study reinforces the use of zebrafish as a model organism to study the behavioral and physiological effects of stress. The UCS protocol may also serve as a screening tool for evaluating new drugs that can be used to treat psychiatric disorders with stress-related etiologies.

Cited by 90 publications

References 76 publications

Divergent effect of fluoxetine on the response to physical or chemical stressors in zebrafish

Divergent effect of fluoxetine on the response to physical or chemical stressors in zebrafish

The integration of sociality, monoamines and stress neuroendocrinology in fish models: applications in the neurosciences

The Integration of Sociality, Monoamines, and Stress Neuroendocrinology in Fish Models: Applications in the Neurosciences

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