Prevention of Transfusion-Acquired Cytomegalovirus Infections in Newborn Infants

Case-control study of symptoms and neonatal outcome of human milk–Transmitted cytomegalovirus infection in premature infants

“…In transfusion-acquired CMV infection, serious or fatal symptoms were observed only in preterm infants born to seronegative mothers. 27 Recently, placental transfer of both neutralizing and IgG anti-CMV antibodies was detected as early as 28 weeks GA (the lower limit for inclusion in that study). 28 Thus premature infants infected after birth may already have some protection against CMV, likely explaining their milder course of infection.…”

Factors associated with primary cytomegalovirus infection during pregnancy

“…The CMV reservoir for susceptible children is constituted by the approximately 1 % of all infants born with congenital CMV infection and the 10% to perhaps 40% of infants who become infected a few months after birth as a result of maternalinfant transmission in particular by means of breast feeding [Stagno et al, 19801. In addition, babies born prematurely and other special groups of infants may acquire CMV infection through blood transfusions [Yeager et al, 1981;Ballard et al 19791. This pool of congenitally and perinatally infected infants excrete large quantities of CMV into urine and saliva for years [Stagno et al, 19831.…”

Detection of antibodies to cytomegalovirus by an improved counterimmunoelectrophoretic procedure

“…Because of the recent trend toward acceptance of IHA as the standard semiquantitative technique in CMV serology [Yeager et al, 1981;Horodniceanu and Michelson, 19801, we considered it of interest to determine whether CIE results, largely regarded as only qualitative, might be predictive of IHA titers. As is evident from Table 111, most of the sera with relatively low IHA titers (< 1:640) gave a single line of precipitate in CIE that appeared late, but the same pattern was exhibited by almost one half of the high titer sera.…”