Prevention of Thromboembolism Using Aspirin after Mitral Valve Replacement with Porcine Bioprosthesis

Núñez, Lisardo; Aguado, M. Gil; Larrea, J.L.; Celemín, Daniel; Oliver, Josè M.

doi:10.1016/s0003-4975(10)60717-5

Cited by 78 publications

(16 citation statements)

References 19 publications

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“…Daily, low-dose aspirin therapy protects against cardiovascular injury (Danese et al, 1971; Kojda, 2004; Nunez et al, 1984) and also lowers the risk of colorectal and other forms of cancer (Bosetti et al , 2002; Jacobs et al , 2005). However, aspirin has several side effects such as gastrointestinal irritation, renal dysfunction, hepatic and allergic reactions (Bergman et al, 1976; Bjorklund et al, 2009; de Weck et al, 2006; Gibson et al, 1956; Rupp et al, 1983; Saltzman et al, 1976; Zucker et al, 1975).…”

Section: Introductionmentioning

confidence: 99%

Too much of a good thing: Long-term treatment with salicylate strengthens outer hair cell function but impairs auditory neural activity

et al. 2010

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Aspirin has been extensively used in clinical settings. Its side effects on auditory function, including hearing loss and tinnitus, are considered as temporary. A recent promising finding is that chronic treatment with high-dose salicylate (the active ingredient of aspirin) for several weeks enhances expression of the outer hair cell (OHC) motor protein (prestin), resulting in strengthened OHC electromotility and enhanced distortion product otoacoustic emissions (DPOAE). To follow up on these observations, we carried out two studies, one planned study of age-related hearing loss restoration and a second unrelated study of salicylate-induced tinnitus. Rats of different strains and ages were injected with salicylate at a dose of 200 mg/kg/day for 5 days per week for 3 weeks or at higher dose levels (250–350 mg/kg/day) for 4 days per week for 2 weeks. Unexpectedly, while an enhanced or sustained DPOAE was seen, permanent reductions in the amplitude of the cochlear compound action potential (CAP) and the auditory brainstem response (ABR) were often observed after the chronic salicylate treatment. The mechanisms underlying these unexpected, permanent salicylate-induced reductions in neural activity are discussed.

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Section: Introductionmentioning

confidence: 99%

Too much of a good thing: Long-term treatment with salicylate strengthens outer hair cell function but impairs auditory neural activity

et al. 2010

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“…Study selection was not restricted by underlying conditions (e.g., established CVD, diabetes, hypertension, dyslipidemia, essential thrombocythemia, or atrial fibrillation). Studies involving patients in an acute (postoperative) setting were not analyzed …”

Section: Systematic Review Strategymentioning

confidence: 99%

“…Studies involving patients in an acute (postoperative) setting were not analyzed. [61][62][63] There were no restrictions on doses being compared provided there was a difference in dosing timing (e.g., in the morning compared to the evening) or frequency (e.g., twice or more per day vs. once per day, alternate-day vs. every day). There were no restrictions on study selection by outcome report.…”

Section: Selection Criteriamentioning

confidence: 99%

The Effects of Different Aspirin Dosing Frequencies and the Timing of Aspirin Intake in Primary and Secondary Prevention of Cardiovascular Disease: A Systematic Review

Bem

Lordkipanidzé

Hodgkinson

et al. 2016

Clin Pharma and Therapeutics

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Enhancing the effectiveness of aspirin by tailoring administration regimens is an important question among health professionals. We conducted a systematic review to evaluate the evidence on the effects of different aspirin regimens in terms of timing (chronotherapy) or frequency of dosing in the prevention of cardiovascular disease. Only two out of the 28 included studies reported long-term cardiovascular outcomes, highlighting an evidence gap that future research should address. The remaining 26 studies used surrogate outcomes.

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“…Patients who do not require oral anticoagulants after the first 3 months may be considered for antiplatelet therapy, e.g. aspirin (Nunez et al, 1984;Stein et al, 1992).…”

Section: Bioprosthetic Valves Long-term Warfarin Not Required In Absementioning

confidence: 99%

Guidelines on oral anticoagulation: third edition

1998

Br J Haematol

300

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Prevention of Thromboembolism Using Aspirin after Mitral Valve Replacement with Porcine Bioprosthesis

Cited by 78 publications

References 19 publications

Too much of a good thing: Long-term treatment with salicylate strengthens outer hair cell function but impairs auditory neural activity

Too much of a good thing: Long-term treatment with salicylate strengthens outer hair cell function but impairs auditory neural activity

The Effects of Different Aspirin Dosing Frequencies and the Timing of Aspirin Intake in Primary and Secondary Prevention of Cardiovascular Disease: A Systematic Review

Guidelines on oral anticoagulation: third edition

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