“…In a randomized controlled trial (RCT) by Beurskens and colleagues, 112,113 patients with long-standing NFFP following BP, AN resection, VZV infection, and trauma receiving 3 months of comprehensive facial PT as opposed to being waitlisted demonstrated statistical improvements in patient-reported facial stiffness and FDI scores and quantitative assessment of lip length; however, no statistical benefit was seen in blinded expert-assessed FGS scores 12 months after therapy (level Ib). In the 2014 RCT by Pourmomeny and colleagues, 114 114 An RCT by Nicastri and colleagues 115 demonstrated that 74% of patients with BP presenting with severe to complete FFP (ie, HBG V/ VI) who received combination pharmacologic therapy (CPT) with prednisone and valacyclovir plus comprehensive PT within 10 days of symptom onset progressed to an HBG of I or II as assessed by 1 blinded expert within 6 months, compared with only 48% of those receiving CPT alone (adjusted P 5 .038) (level Ib). In summary, recent evidence supports the use of PT in acute FFP and long-standing NFFP.…”