Prevention of Sudden Cardiac Death by Dietary Pure ω-3 Polyunsaturated Fatty Acids in Dogs

Billman, George E.; Kang, Jing; Leaf, Alexander

doi:10.1161/01.cir.99.18.2452

Cited by 360 publications

(253 citation statements)

References 28 publications

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“…Some studies have observed a beneficial impact of n-3 PUFAs on the prevention of ventricular arrhythmias in dogs (37), rats (38,39) and nonhuman primates (40). Regarding in vitro studies, Kang and Leaf observed that addition of low micromolar concentrations of EPA or DHA slowed the beating rate of the myocytes (41).…”

Section: Discussionmentioning

confidence: 99%

Influence of n-3 fatty acids on cardiac autonomic activity among Nunavik Inuit adults

Valera¹,

Dewailly

Anassour-Laouan-Sidi³

et al. 2011

International Journal of Circumpolar Health

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Objectives. Inuit from Nunavik (northern Quebec) consume large amounts of fish and marine mammals, which are important sources of n-3 polyunsaturated fatty acids (n-3 PUFAs). These substances have a beneficial impact on heart rate (HR) and heart rate variability (HRV). However, it is unknown if this beneficial impact remains significant in populations with high mercury exposure. The study assessed the impact of n-3 PUFAs (Docosahexaenoic [DHA] and Eicosapentaenoic acid [EPA]) on resting HR and HRV among Nunavik Inuit adults considering mercury and other potential confounders. Study design. Cross-sectional study employing clinical measurements. Methods. Complete data were collected among 181 adults ≥40 years old (109 women and 72 men) living in the 14 coastal villages of Nunavik. Several indices of HRV were derived from a 2-hour Holter monitoring assessment. n-3 PUFAs levels were measured in membrane erythrocytes. Simple linear regression was used to analyse the relationship between n-3 PUFAs levels and resting HR and HRV parameters while multiple linear regressions were carried out to control for confounders. Results. In the overall analyses, EPA was associated with SDANN (β=0.07, p=0.04) and LF norm (β=-1.84, p=0.03) after adjusting for confounders. Among women, DHA was associated with resting HR (β=-1.40, p=0.03) while EPA was associated with SDNN (β=0.08, p=0.03), SDANN (β=0.09, p=0.02) and resting HR (β=-2.61, p=0.002). No significant association was observed in men. Conclusions. These results suggest a beneficial impact of n-3 PUFAs on resting HR and HRV among Nunavik Inuit women.

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Section: Discussionmentioning

confidence: 99%

Influence of n-3 fatty acids on cardiac autonomic activity among Nunavik Inuit adults

Valera¹,

Dewailly

Anassour-Laouan-Sidi³

et al. 2011

International Journal of Circumpolar Health

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“…Original observations in experimental myocardial infarction 11 and later studies by McLennan et al [12][13][14] in rats and monkeys suggested that omega-3 FAs had a direct protective effect on the heart itself. In a dog model of ventricular tachyarrhythmia, 15 infused omega-3 FAs reduced the number of potentially fatal arrhythmias. Investigations using isolated cardiac myocytes revealed that EPA and DHA could prolong the refractory state of these cells by interaction with fast-acting sodium channels and L-type calcium channels.…”

mentioning

confidence: 99%

Omega-3 Fatty Acids in Cardiac Biopsies From Heart Transplantation Patients

et al. 2004

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Background-Omega-3 fatty acids (FAs) appear to reduce the risk of sudden death from myocardial infarction. This reduction is believed to occur via the incorporation of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) into the myocardium itself, altering the dynamics of sodium and calcium channel function. The extent of incorporation has not been determined in humans. Methods and Results-We first determined the correlation between red blood cell (RBC) and cardiac omega-3 FA levels in 20 heart transplant recipients. We then examined the effects of 6 months of omega-3 FA supplementation (1 g responses among tissues were not significantly different). Conclusions-Although any of the tissues examined could serve as a surrogate for cardiac omega-3 FA content, RBC EPAϩDHA was highly correlated with cardiac EPAϩDHA; the RBC omega-3 response to supplementation was similar to that of the heart; RBCs are easily collected and analyzed; and they have a less variable FA composition than plasma. Therefore, RBC EPAϩDHA (also called the Omega-3 Index) may be the preferred surrogate for cardiac omega-3 FA status.

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“…Rats chronically fed a diet high in n-3 PUFA were significantly less likely to have ventricular fibrillation during acute myocardial ischemia than were animals fed a control diet [7]. Similarly, the acute infusion of n-3 PUFA in a dog model of acute ischemic ventricular fibrillation was associated with a marked reduction in the risk of the arrhythmia [8]. The Physician's Health study showed a reduction in sudden death with higher fish intake but no reduction in the risk of myocardial infarction [9].…”

Section: Meritt H Raittmentioning

confidence: 93%

Are n-3 Polyunsaturated Fatty Acids Antiarrhythmic in the Absence of Ischemia?

Raitt

2008

Cardiovasc Drugs Ther

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Prevention of Sudden Cardiac Death by Dietary Pure ω-3 Polyunsaturated Fatty Acids in Dogs

Abstract: These results indicate that purified omega-3 fatty acids can prevent ischemia-induced ventricular fibrillation in this dog model of sudden cardiac death.

Cited by 360 publications

References 28 publications

Influence of n-3 fatty acids on cardiac autonomic activity among Nunavik Inuit adults

Influence of n-3 fatty acids on cardiac autonomic activity among Nunavik Inuit adults

Omega-3 Fatty Acids in Cardiac Biopsies From Heart Transplantation Patients

Are n-3 Polyunsaturated Fatty Acids Antiarrhythmic in the Absence of Ischemia?

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