Prevention of stress-induced disturbances of contractility of nonischemic regions of the heart in myocardial infarction by gamma-hydroxybutyric acid

Досмагамбетова, Р. С.

doi:10.1007/bf00834301

Cited by 5 publications

(1 citation statement)

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“…These findings are consistent with the small body of published literature reporting GHB neuroprotective effects, as GHB has been shown to exert tissue protective effects in both in vitro and in vivo model systems. Specifically, GHB and GBL have been shown to be protective in gastrointestinal, 19 hepatic, 20 myocardial, 21,22 and cerebral 15–17,23–32 models of ischemia. With respect to the latter, past studies have reported that GHB and GBL produce cerebral neuroprotection by decreasing cerebral energy metabolism and oxygen consumption in the hypoxic‐ischemic rodent, canine, and human brain 23–32 .…”

Section: Discussionmentioning

confidence: 99%

γ‐Hydroxybutyrate (GHB), γ‐Butyrolactone (GBL), and 1,4‐Butanediol (1,4‐BD) Reduce the Volume of Cerebral Infarction in Rodent Transient Middle Cerebral Artery Occlusion

Sadasivan

Maher

Quang

2006

Annals of the New York Academy of Sciences

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gamma-Hydroxybutyric acid (GHB), an endogenous organic acid catabolite of gamma-aminobutyric acid (GABA), has been shown to have tissue-protective effects in various organs, including the brain. We examined the potential neuroprotective effect of GHB and its chemical precursors, gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD), in the rodent ischemic stroke model by intraluminal filament middle cerebral artery occlusion (MCAO). Adult male Sprague-Dawley rats underwent transient left-sided MCAO and received intraperitoneal treatment with 300 mg/kg of GHB, GBL, 1,4-BD, or control vehicle given at 30 min before, as well as 180 and 360 min after the onset of ischemia. Infarct volumes were determined 24 h after MCAO. In transient MCAO, the mean volume of infarction for control rats was 464.4 +/- 17.9 cu.mm versus 273.6 +/- 53.1, 233.3 +/- 44.7, and 275.4 +/- 39.9 cu.mm for rats treated with 1,4-BD (P < 0.05), GBL (P < 0.05), and GHB (P < 0.05), respectively. We conclude that GHB, GBL, and 1,4-BD protect against rat focal cerebral ischemia from transient MCAO.

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