Prevention of skin tumors induced by 7,12-dimethylbenz(a)anthracene in mice by black seed oil

El‐Mofty, M.M.; Abdel-Galil, A.M.; Shwaireb, Mohamed H.; El–Dakhakhny, M.; Rizk, A.; Hofny, EmanR.M

doi:10.3892/or.4.1.139

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thymoquinone is the main constituent of the volatile oil [2]. The pharmacological activities of either the drug, its oil and fractions of the volatile oil, or of isolated compounds including a polymer observed so far included protection against histamine-induced bronchospasm (guinea-pig) [3], relaxation of spontaneous contractions of rabbit jejunum [4], protection against compounds inducing gastrointestinal ulcers [5], choleretic [6] and uricosuric effects [6], analgesic [7] and COX-inhibiting effects [8], improvement of the lipid profile [9], an antibacterial effect [10], [11], protection against D-galactosamine-induced hepatotoxicity [9], effects against some carcinogenesis processes [12] and an antidiabetic effect (extrapancreatic rather than insulin stimulatory effect) [13]. In contrast to most other observations, the intratracheal pressure was increased by applying the volatile oil to guinea-pigs [14] which is rather confusing regarding usefulness in respiratory diseases.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Nigellone and Thymoquinone on Inhibiting Trachea Contraction and Mucociliary Clearance

Wienkötter¹,

Höpner²,

Schütte³

et al. 2008

Planta Med

View full text Add to dashboard Cite

NIGELLA SATIVA L. has many effects including those on the gastrointestinal tract and trachea and is, therefore, used in the Mediteranean area and in India/Pakistan. Our aim was to investigate the effect of two main constituents, nigellone and thymoquinone, on trachea (antispasmodic effect) and their influence on respiratory clearance. The effects on Ba (2+)-, carbachol- and leukotriene-induced trachea contractions and the transport of the fluorescence dye rhodamin B concerning ciliary action in the tracheal area were investigated using a microdialysis technique. Nigellone and high concentrations of thymoquinone had a concentration-dependent inhibitory effect on the trachea when being contracted by the depolarizing effect of Ba (2+). The trachea contractions induced by leukotriene-d (4) were inhibited by nigellone and by thymoquinone. The cholinergic system (stimulation by carbachol) was hardly involved. The rate of ciliary clearance (mucociliary transport) was slightly modified by a high thymoquinone concentration (153.0 vs. 505.0 sec/12 mm distance, respectively), and was highly increased by nigellone (217.5 vs. 505.0 sec/12 mm distance). In conclusion, this study provides evidence for an antispasmodic effect and an increase in mucociliary clearance for nigellone but not for thymoquinone. Altogether the data indicate that nigellone but not thymoquinone may be useful in treatment of different respiratory diseases.

show abstract

Section: Introductionmentioning

confidence: 99%

The Effect of Nigellone and Thymoquinone on Inhibiting Trachea Contraction and Mucociliary Clearance

Wienkötter¹,

Höpner²,

Schütte³

et al. 2008

Planta Med

View full text Add to dashboard Cite

show abstract

“…N. sativa volatile oil constituents such as thymoquinone inhibited 20-methylcholanthrene-induced fibrosarcoma tumorigenesis in male Swiss albino mice, most likely through antioxidant activity and interference with DNA synthesis, coupled with the enhancement of detoxification processes (18). Previously, the post-initiation application of N. sativa oil was shown to exert potent chemopreventive potential on DmBA-induced skin carcinogenesis (39) and on methylcholanthrene-induced soft tissue sarcoma development in female BALB/c mice (40). more recently, pre-exposure to the N. sativa extract and thymoquinone, before gemcitabine or oxaliplatin in vitro, resulted in a 60-80% growth inhibition of pancreatic cancer cells compared with 15-25% when gemcitabine or oxaliplatin were used alone (19).…”

Section: Discussionmentioning

confidence: 99%

Cancer chemopreventive potential of volatile oil from black cumin seeds, Nigella sativa L., in a rat multi-organ carcinogenesis bioassay

Salim¹

2010

Oncology Letters

View full text Add to dashboard Cite

Abstract. Nigella sativa (N. sativa) is a herbal plant of the Ranunculaceae family that has been widely used for various medicinal and nutritional purposes. Volatile oil extracts along with its major constituents, such as thymoquinone, have recently attracted considerable attention for their antioxidant, immunoprotective and antitumor properties. The present study was conducted to assess the chemopreventive potential of crude oils in N. sativa on tumor formation using a well-established rat multi-organ carcinogenesis model featuring initial treatment with five different carcinogens. Post-initiation administration of 1000 or 4000 ppm N. sativa volatile oil in the diet of male Wistar rats for 30 weeks significantly reduced malignant and benign colon tumor sizes, incidences and multiplicities. The treatment also significantly decreased the incidences and multiplicities of tumors in the lungs and in different parts of the alimentary canal, particularly the esophagus and forestomach. Bromodeoxyuridine labeling indices, reflecting cell proliferation were significantly decreased in various organs and lesions after treatment with the two doses of N. sativa. The plasma levels of insulin growth factor, triglycerides and prostaglandin E2 were also altered. The findings show, for the first time, that N. sativa administration exerts potent inhibitory effects on rat tumor development and on cellular proliferation in multiple organ sites. In particular, the ability to significantly inhibit murine colon, lung, esophageal and forestomach tumors was demonstrated in the post-initiation phase, with no evidence of clinical side effects. The mechanisms are likely to be related to suppression of cell proliferation. IntroductionThe search for compounds that prevent cancer has intensified with mounting evidence that many types of cancer are caused or triggered by factors related to lifestyle and environment, particularly agents in foodstuffs. There is a growing body of evidence from in vitro and in vivo experiments that N. sativa seeds (black cumin seeds) or the extracted volatile oils, exert anti-carcinogenic effects (1,2). N. sativa is a common herbal plant that has been used since ancient times by the Egyptians and Greeks for various medicinal purposes. It has many common applications by people in the countries surrounding the Mediterranean Sea, the Arab world, Indians and Persians as an antimicrobial, antihelmintic, diuretic, diaphonetic and antiasthmatic medicine. N. sativa is also used by the Europeans, Americans and Japanese as a food additive for cheese and bakery products (3).A large number of in vitro and in vivo studies have shown significant modulatory effects of N. sativa extracts with different pathological, toxicological and cytotoxic protocols. Previously, volatile oils from N. sativa seeds were found to possess antitumor effects in vitro against Ehrlich ascites carcinoma, Dalton's lymphoma ascites and sarcoma (S-180) cell lines (4). Recently, it was postulated that extracted proteins from N. sativa exhibit modulatory ef...

show abstract

Prevention of skin tumors induced by 7,12-dimethylbenz(a)anthracene in mice by black seed oil

Cited by 2 publications

References 0 publications

The Effect of Nigellone and Thymoquinone on Inhibiting Trachea Contraction and Mucociliary Clearance

The Effect of Nigellone and Thymoquinone on Inhibiting Trachea Contraction and Mucociliary Clearance

Cancer chemopreventive potential of volatile oil from black cumin seeds, Nigella sativa L., in a rat multi-organ carcinogenesis bioassay

Contact Info

Product

Resources

About