Prevention of selenite-induced cataractogenesis by acetyl-l-carnitine: An experimental study

Geraldine, Pitchairaj; Sneha, B Brijit; Elanchezhian, R.; Ramesh, E.; Kalavathy, C M; Kaliamurthy, Jayaraman; Thomas, Philip A.

doi:10.1016/j.exer.2006.07.009

Cited by 52 publications

(36 citation statements)

References 54 publications

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“…Hence, it is important to identify factors that contribute to cataractogenesis with a view to developing novel therapeutic and preventive strategies. It has previously shown that ALC exhibits anticataractogenic activity in an in vitro and in vivo model of selenite cataractogenesis by maintaining antioxidant enzymes at near normal levels and by controlling lipid peroxidation (Geraldine et al, 2006). These observations suggest a novel use for ALC as a possible cataract-preventing drug (Elanchezhian et al, 2009).…”

Section: Effect On Cataractmentioning

confidence: 95%

Metabolic Modulators to Treat Cardiac Arrhythmias Induced by Ischemia and Reperfusion

Najafi¹,

Eteraf-Oskouei²

2012

Tachycardia

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Section: Effect On Cataractmentioning

confidence: 95%

Metabolic Modulators to Treat Cardiac Arrhythmias Induced by Ischemia and Reperfusion

Najafi¹,

Eteraf-Oskouei²

2012

Tachycardia

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“…Various reports have shown that the use of enzyme inhibitors an anhydrous release carbon dioxide, ardostine antioxidants, N-steelcartozin and vitamin E, have reduced progression of cataract [4,20] . Geraldine and et al [21] suggested that acetyl-l-carnitine (ALCAR) is able to significantly retard experimental selenite-induced cataractogenesis in Wister rat model.…”

Section: Discussionmentioning

confidence: 99%

“…Bio-microscopic slit lamp study of the eyes was performed with 3 day intervals for 20 days. The degree of opacification was assessed according to a study that described as follows: grade 0, absence of opacification (gridlines clearly visible); grade 1, slight degree of opacification (minimal clouding of gridlines and gridlines still visible); grade 2, diffuse opacification involving almost the entire lens (moderate clouding of gridlines and gridlines faintly visible); grade 3, extensive thick opacification involving the entire lens (total clouding of gridlines and gridlines not seen at all [7] .…”

Section: Stagementioning

confidence: 99%

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Tavşan Modelinde Silymarinin Selenit ile Oluşturulmuş Katarakt Üzerine Koruyucu Rolü

Kabir¹,

Fattahian²,

Riazi-Esfehani³

et al. 2014

Kafkas Univ Vet Fak Derg

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The study was designed to investigate silymarine as preventive agent in selenite-induced cataract in rabbits. Eighteen rabbits were concluded and divided equally into negative control (I), positive control (II) and test (III) groups, each 6. After clinical and ophthalmoscope, bio-microscope slit lamp equipped with a digital camera and ultrasonographical examinations of rabbits' eyes, selenite sodium was administered subcutaneously on the neck in all rabbits at day 0 of the study. After induction of anesthesia, lateral recumbency and making a pore in globe 0.1ml of saline solution 0.9% in group II and 0.1ml of silymarine were injected into vitreous in group III. Any agent did not administrate in group I. Selenite sodium was injected in days third and sixth in all rabbits subcutaneously. The bio-microscopic slit lamp study showed grade one and two cataract in day 4 and 8, and grade three in day 11 in all rabbits in group I and II. In group III, three rabbits on the eighth day and four until the end of the eleventh day presented grade one cataract. Anterior lens capsule thickness was less in group III in comparison to group I and II, and posterior capsule thickness in group III was significant statistically by ultrasonography on day 20 and the anterior-posterior lens diagonal length in the experimental group comparing to the control groups was longer significantly. Selenite sodium showed cataractogenic character and silymarine as probable protective role on selenite -induced cataract in rabbit model. Keywords: Cataract, Selenite sodium, Silymarine, Rabbit Tavşan Modelinde Silymarinin Selenit ile Oluşturulmuş Katarakt Üzerine Koruyucu Rolü ÖzetBu çalışma tavşanlarda selenit ile oluşturulmuş katarakt üzerine önleyici ajan olarak silymarinin araştırılması için tasarlanmıştır. Her biri altılı gruplardan oluşan 18 tavşan negatif kontrol (I), pozitif kontrol (II) ve test (III) grupları olmak üzere eşit şekilde ayrıldı. Tavşan gözlerinin klinik ve oftalmoskop, dijital kameralı biyo-mikroskop yarık (slit) lamba ve ultrasonografik muayene sonrası sodyum selenit çalışmanın 0. gününde tüm tavşanlara boyuna subkutan olarak uygulandı. Anestezinin başlatılmasından sonra, yan yatırılarak ve küre üzerine gözenek oluşturularak 0.1ml %0.9'luk tuz solusyonu grup II'deki ve 0.1ml silymarin grup III'deki hayvanların vitreouslarına enjekte edildi. Grup I'deki hayvanlara ise herhangi bir madde enjeksiyonu yapılmadı. Selenit sodyum subkutan olarak tüm tavşanlara üçüncü ve altıncı günde enjekte edildi. Biyo-mikroskop yarık (slit) lamba çalışması birinci ve ikinci derece kataraktın 4. ve 8. günlerde ve üçüncü derece kataraktın ise 11.günde grup I ve II'deki tüm tavşanlarda gözlemlendiğini ortaya koydu. Grup III'de, üç tavşanda sekizinci günde ve dördünde ise onbirinci günün sonunda birinci derece katarakt gözlemlendi. Yirminci gündeki ultrasonografiye gore anterior lens kapsül kalınlığı, Grup I ve II 'ye göre grup III daha az ve posterior lens kapsül kalınlığı grup III'de istatistiksel olarak anlamlı bulundu. Anterior-posterior lens diagona...

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“…Since oxidative stress is implicated in cataract formation, application of an antioxidant capable of successfully penetrating the lens tissue represents a logical approach to counteract oxidation-related cataractogenesis. Several compounds with antioxidant properties have been reported to prevent selenite-induced cataracts, such as resveratrol [12], saffron [13], ellagic acid [14], garlic [15], melatonin [16], drevogenin D [17], caffeine [18], ebselen [19], lycopene in vivo [20], N-acetyl-L-carnitine in vitro and in vivo [21][22][23], and Ocimum sanctum in vivo and ex vivo [24]. In fact, N-acetylcysteine (NAC), a glutathione (GSH) prodrug, has previously been tried in selenite-induced cataracts in vivo [25] and was shown to prevent oxidative damage to the lens, slowing down cataractogenesis.…”

mentioning

confidence: 99%

Prevention and reversal of selenite‐induced cataracts by N‐acetylcysteine amide in Wistar rats

Maddirala

Tobwala

Karacal

et al. 2016

Acta Ophthalmologica

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Background: The present study sought to evaluate the efficacy of N-acetylcysteine amide (NACA) eye drops in reversing the cataract formation induced by sodium selenite in male Wistar rat pups. Methods: Forty male Wistar rat pups were randomly divided into a control group, an N-acetylcysteine amide-only group, a sodium selenite-induced cataract group, and a NACA-treated sodium selenite-induced cataract group. Sodium selenite was injected intraperitoneally on postpartum day 10, whereas N-acetylcysteine amide was injected intraperitoneally on postpartum days 9, 11, and 13 in the respective groups. Cataracts were evaluated at the end of week 2 (postpartum day 14) when the rat pups opened their eyes. N-acetylcysteine amide eye drops were administered beginning on week 3 until the end of week 4 (postpartum days 15 to 30), and the rats were sacrificed at the end of week 4. Lenses were isolated and examined for oxidative stress parameters such as glutathione, lipid peroxidation, and calcium levels along with the glutathione reductase and thioltransferase enzyme activities. Casein zymography and Western blot of m-calpain were performed using the water soluble fraction of lens proteins. Results: Morphological examination of the lenses in the NACA-treated group indicated that NACA was able to reverse the cataract grade. In addition, glutathione level, thioltransferase activity, m-calpain activity, and m-calpain level (as assessed by Western blot) were all significantly higher in the NACA-treated group than in the sodium selenite-induced cataract group. Furthermore, sodium selenite-injected rat pups had significantly higher levels of malondialdehyde, glutathione reductase enzyme activity, and calcium levels, which were reduced to control levels upon treatment with NACA.

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Prevention of selenite-induced cataractogenesis by acetyl-l-carnitine: An experimental study

Cited by 52 publications

References 54 publications

Metabolic Modulators to Treat Cardiac Arrhythmias Induced by Ischemia and Reperfusion

Metabolic Modulators to Treat Cardiac Arrhythmias Induced by Ischemia and Reperfusion

Tavşan Modelinde Silymarinin Selenit ile Oluşturulmuş Katarakt Üzerine Koruyucu Rolü

Prevention and reversal of selenite‐induced cataracts by N‐acetylcysteine amide in Wistar rats

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