Prevention of renal dysfunction by nutraceuticals prepared from oil rich plant foods

Al‐Okbi, Sahar Y.; Mohamed, Doha A.; Hamed, Thanaa E.; Esmail, Reham Sh.; Donya, Souria M.

doi:10.12980/apjtb.4.201414b66

Cited by 31 publications

(18 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Natural products of plant origin (nutraceuticals) have been proposed as a potential source of natural antioxidants with pharmaceutical activity ( 9 - 11 ). Also the therapeutic effects of nutraceuticals for curing kidney dysfunction are being studied ( 12 ). Elevated oxidative stress and reduced antioxidant defense systems in patients with diabetes and ESRD accelerate the prevalence of chronic complications such as hemolysis.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Plasma Oxidative Biomarkers and Conformational Modifications of Hemoglobin in Patients With Diabetes on Hemodialysis

Ansarihadipour¹,

Dorostkar²

2014

Iran Red Crescent Med J

View full text Add to dashboard Cite

Background:Diabetes is associated with an increased generation of reactive oxygen species (ROS), which plays an important role in the development of oxidative stress and anemia.Objectives:The main purpose of this study was to investigate whether patients with diabetes undergoing hemodialysis (HD) were susceptible to oxidative stress and whether resulting damages affect the structure of hemoglobin (Hb) and plasma proteins.Patients and Methods:Twenty patients with diabetes undergoing HD, 20 patients with diabetes and normal renal function, and 20 age- and sex-matched healthy subjects were included in this study. Methaemoglobin (Met-Hb), hemichrome and conformational changes of Hb were analyzed as oxidative markers in erythrocytes. Ferric reducing ability of plasma (FRAP) and protein carbonyl content (PCO) were determined as plasma oxidative biomarkers. Also triglyceride, cholesterol, albumin, blood urea nitrogen (BUN), creatinine, glucose and uric acid were assayed as biochemical parameters of plasma.Results:Patients with diabetes undergoing hemodialysis had significantly lower levels of PCO and albumin (P < 0.05), but significantly higher levels of FRAP, BUN, creatinine and uric acid (P < 0.05) as compared to patients with diabetes and normal renal function. Linear regression analysis showed significant negative correlations between PCO and FRAP (r = -0.53), oxy-Hb (r = -0.88) and Hb absorbance at 340 nm (r = -0.79), 420 nm (r = -0.85) and 577 nm (r = -0.68) in patients with diabetes undergoing hemodialysis. Also PCO was significantly and positively correlated with Hb absorbance at 275 nm (r = 0.63) and 560 nm (r = 0.61) which confirmed the oxidative damage to erythrocytes in control subjects.Conclusions:Hemodialysis exacerbates oxidative stress and conformational changes of Hb in patients with diabetes on hemodialysis. The FRAP value can be used as a positive determinant, while PCO and Hb derivatives can be used as negative determinants of oxidative stress in patients with diabetes.

show abstract

Section: Introductionmentioning

confidence: 99%

Comparison of Plasma Oxidative Biomarkers and Conformational Modifications of Hemoglobin in Patients With Diabetes on Hemodialysis

Ansarihadipour¹,

Dorostkar²

2014

Iran Red Crescent Med J

View full text Add to dashboard Cite

show abstract

“…β-Sitosterol, which is the main compound showing neurite outgrowth-promoting activity in sunflower seed extract, is one of the well-known plant sterols and is found in avocados, soybeans and corn [ 32 , 33 ]. It was reported that β-sitosterol has cholesterol metabolic action, antibacterial action and anticancer action [ 34 , 35 , 36 ].…”

Section: Resultsmentioning

confidence: 99%

Neurite Outgrowth-Promoting Activity of Compounds in PC12 Cells from Sunflower Seeds

et al. 2020

View full text Add to dashboard Cite

In the current super-aging society, the establishment of methods for prevention and treatment of Alzheimer’s disease (AD) is an urgent task. One of the causes of AD is thought to be a decrease in the revel of nerve growth factor (NGF) in the brain. Compounds showing NGF-mimicking activity and NGF-enhancing activity have been examined as possible agents for improving symptoms. In the present study, sunflower seed extract was found to have neurite outgrowth-promoting activity, which is an NGF-enhancing activity, in PC12 cells. To investigate neurite outgrowth-promoting compounds from sunflower seed extract, bioassay-guided purification was carried out. The purified active fraction was obtained by liquid-liquid partition followed by some column chromatographies. Proton nuclear magnetic resonance and gas chromatography-mass spectrometry analyses of the purified active fraction indicated that the fraction was a mixture of β-sitosterol, stigmasterol and campesterol, with β-sitosterol being the main component. Neurite outgrowth-promoting activities of β-sitosterol, stigmasterol, campesterol and cholesterol were evaluated in PC12 cells. β-Sitosterol and stigmasterol showed the strongest activity of the four sterol compounds (β-sitosterol ≈ stigmasterol > campesterol > cholesterol), and cholesterol did not show any activity. The results indicated that β-sitosterol was the major component responsible for the neurite outgrowth-promoting activity of sunflower seeds. Results of immunostaining also showed that promotion by β-sitosterol of neurite formation induced by NGF was accompanied by neurofilament expression. β-Sitosterol, which showed NGF-enhancing activity, might be a candidate ingredient in food for prevention of AD.

show abstract

“…ALA also reduces serum triglycerides and the development of thrombosis and arteriosclerosis (Pszczola, 1998). Also, flaxseed was shown to have an impact on the treatment of lupus nephritis (Clark et al, 1995) in humans and improvement of renal dysfunction during cisplatin treatment in rats (Al-Okbi et al, 2014), pointing to its reno-protective effect. Flaxseed oil attenuated the decline in renal function and reduced glomerular injury (Caligiuri et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the therapeutic effect of <em>Nigella sativa</em> crude oil and its blend with omega-3 fatty acid-rich oils in a modified hepatorenal syndrome model in rats

et al. 2015

View full text Add to dashboard Cite

SUMMARY:In the present study, the hepato and reno-protective effect of Nigella sativa crude oil and its binary blend with omega-3 fatty acid-rich oils (fish and flaxseed oils) was studied in a modified hepatorenal syndrome model (MHRS) in rats. MHRS was induced through feeding a high fructose diet followed by an intraperitoneal injection of galactosamine hydrochloride. Nigella oil and its different blends were given as a daily oral dose to MHRS rats. Two control groups of MHRS and normal healthy rats were run. Different biochemical and nutritional parameters were assessed. The induction of MHRS produced liver and kidney dysfunction, and elevated oxidative stress, an inflammatory biomarker, endothelin 1, and plasma cholesterol. Reduced plasma high density lipoprotein cholesterol, albumin and Ca and elevated urinary N-acetyl-β-D-Glucosaminidase and liver fats were noticed. The administration of Nigella crude oil that originally had 0.2% total omega-3 fatty acids or its blend with fish oil (17.9% omega-3) or flaxseed oil (42.1% omega-3) significantly improved all biochemical parameters of MHRS. There was no significant difference in the biochemical parameters among the different oil treated groups regardless of the omega-3 fatty acid content. This may point out to the potential profound effect of the volatile oil fraction of Nigella crude oil which may compensates for its low omega-3 content. KEYWORDS: Hepatorenal syndrome; Nigella crude oil; Oil blends; Omega-3 fatty acidsRESUMEN: Evaluación del efecto terapéutico del aceite crudo de Nigella sativa y su mezcla con aceites ricos en ácidos grasos omega-3 en un modelo de síndrome hepatorenal modificado en ratas. En el presente estudio, el efecto hepato-y reno-protector de aceites crudos de Nigella sativa y su mezcla binaria con aceites ricos en ácidos grasos omega-3 (pescado y aceites de linaza) fue estudiado en un modelo modificado de síndrome hepatorenal (MHRS) en ratas. MHRS fue inducido a través de la alimentación de una dieta alta en fructosa seguido de la inyección intraperitoneal de clorhidrato de galactosamina. Diferentes aceites fueron suministrados como dosis oral diaria a ratas con MHRS. Se realizaron dos grupos de control de MHRS y ratas sanas normales. Se evaluaron diferentes parámetros bioquímicos y nutricionales. La inducción de la MHRS produce disfunción hepática y renal, elevado estrés oxidativo y biomarcadores inflamatorios, endotelina 1, y colesterol en plasma. Se observó una reducción del colesterol plasmatico de lipoproteínas de alta densidad, albúmina y Ca, elevación en orina de N-acetil-β-D-glucosaminidasa y de la grasa del hígado. La administración de aceite crudo de Nigella que tiene un 0,2% de ácidos grasos omega-3 totales o su mezcla con aceite de pescado (17,9% de omega-3) o aceite de linaza (42,1% de omega-3) mejoró significativamente todos los parámetros bioquímicos de MHRS. No hubo diferencia significativa en los parámetros bioquímicos entre los diferentes grupos tratados con los aceites ensayados independientemente del contenido de áci...

show abstract

Prevention of renal dysfunction by nutraceuticals prepared from oil rich plant foods

Abstract: Administration of the studied nutraceuticals proved to possess protective role against cisplatin-induced nephrotoxicity, chromosomal aberration and abnormal sperms. All studied nutraceuticals showed complete safety.

Cited by 31 publications

References 60 publications

Comparison of Plasma Oxidative Biomarkers and Conformational Modifications of Hemoglobin in Patients With Diabetes on Hemodialysis

Comparison of Plasma Oxidative Biomarkers and Conformational Modifications of Hemoglobin in Patients With Diabetes on Hemodialysis

Neurite Outgrowth-Promoting Activity of Compounds in PC12 Cells from Sunflower Seeds

Evaluation of the therapeutic effect of <em>Nigella sativa</em> crude oil and its blend with omega-3 fatty acid-rich oils in a modified hepatorenal syndrome model in rats

Contact Info

Product

Resources

About