Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy.

Teasdale, John D.; Segal, Zindel V.; Williams, Jane; Ridgeway, Valerie; Soulsby, Judith M.; Lau, Mark A.

doi:10.1037/0022-006x.68.4.615

Cited by 2,422 publications

(2,129 citation statements)

References 29 publications

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“…The online mindfulness course assessed in this study comprised elements of mindfulness-based stress reduction (MBSR; Kabat-Zinn, 1990) and mindfulness-based cognitive therapy (MBCT; Teasdale, Segal, Williams, Ridgeway, Soulsby, & Lau, 2000). The course is run by the Mental Health Foundation (UK) and Wellmind Media (UK) and was developed in conjunction with leading UK mindfulness instructors (Krusche, Cyhlarova, King, & Williams, 2012).…”

Section: Online Mindfulness Coursementioning

confidence: 99%

Internet-based instructor-led mindfulness for work-related rumination, fatigue, and sleep: Assessing facets of mindfulness as mechanisms of change. A randomized waitlist control trial.

Querstret

Cropley

Fife‐Schaw

2017

Journal of Occupational Health Psychology

119

138

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Title. Internet-based instructor-led mindfulness for work-related rumination, fatigue and sleep: assessing facets of mindfulness as mechanisms of change. A randomised waitlist control trial.Abstract. This study aimed to extend our theoretical understanding of how mindfulnessbased interventions exert their positive influence on measures of occupational health.Employing a randomised waitlist control study design, we sought to: (1) assess an Internetbased instructor-led mindfulness intervention for its effect on key factors associated with 'recovery from work', specifically, work-related rumination, fatigue and sleep quality; (2) assess different facets of mindfulness (acting with awareness, describing, non-judging, and non-reacting) as mechanisms of change; and (3) assess whether the effect of the intervention was maintained over time by following up our participants after three and six months.Participants who completed the mindfulness intervention (N=60) reported significantly lower levels of work-related rumination and fatigue, and significantly higher levels of sleep quality, when compared with waitlist control participants (N=58). Effects of the intervention were maintained at three and six month follow-up with medium to large effect sizes. The effect of the intervention was primarily explained by increased levels of only one facet of mindfulness (acting with awareness). This study provides support for online mindfulness interventions to aid recovery from work and furthers our understanding with regards to how mindfulness interventions exert their positive effects.

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Section: Online Mindfulness Coursementioning

confidence: 99%

Internet-based instructor-led mindfulness for work-related rumination, fatigue, and sleep: Assessing facets of mindfulness as mechanisms of change. A randomized waitlist control trial.

Querstret

Cropley

Fife‐Schaw

2017

Journal of Occupational Health Psychology

119

138

View full text Add to dashboard Cite

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“…Different kinds of modifications of CBT were found to be effective as well, such as mindfulnessbased cognitive therapy (MBCT) [26][27][28]. MBCT uses conventional methods of CBT which combined with mindfulness meditation.…”

Section: Introductionmentioning

confidence: 99%

“…However, many investigators found that MBCT might not reduce the risk of developing a new relapse of depression in patients with 2 previous episodes [28,32]. Investigators offered two hypotheses.…”

Section: Introductionmentioning

confidence: 99%

“…For patients with higher numbers of episodes, less environmental stress is needed to motivate relapse [33]). The preventative effect of MBCT was assumed to attribute to disrupt these processes at times of potential relapse by decreasing the extent of depressive thought reactivated by negative feelings [28,34]. The second was that there might be different categories of depression.…”

Section: Introductionmentioning

confidence: 99%

“…One category might be associated with reaction to life events, namely among patients with fewer numbers of previous episodes. Another category of depression might be associated with heightened rumination, namely among patients with a higher number of previous episodes [28].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

One-year outcomes of a randomized clinical trial treating depression in low-income minority women.

Miranda

Green

Krupnick

et al. 2006

Journal of Consulting and Clinical Psychology

112

102

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Background: The risk of relapse in major depressive disorder (MDD) is associated with high worldwide disease burden. Cognitive behavioral therapy (CBT) and its modifications might be effective in relapse prevention. The aim of this review was to evaluate the efficacy of these treatments for reducing relapse of MDD. Methods: The retrieval was performed in the databases of MEDLINE via Pubmed, EMBASE and PsycINFO via OVID, The Cochrane Library and four Chinese databases. Clinical trials registry platforms and references of relevant articles were retrieved as well. Hazard ratio (HR) and corresponding 95% confidence interval (CI) were used to pool evidences. Results: A total of 16 eligible trials involving 1945 participants were included. In the first 12 months, CBT was more efficacious than control in reducing the risk of developing a new episode of depression for MDD patients in remission (HR:0.50, 95%CI:0.35-0.72, I 2 = 11%). Mindfulness-based cognitive therapy (MBCT) was more efficacious than control only among patients with 3 or more previous depressive episodes (HR:0.46, 95%CI:0.31-0.70, I 2 = 38%). Besides, compared with maintenance antidepressant medication (m-ADM), MBCT was a more effective intervention (HR:0.76, 95%CI:0.58-0.98, I 2 = 0%). These positive effects might be only maintained at two and nearly 6 years follow up for CBT. Conclusion: The use of CBT for MDD patients in remission might reduce risk of relapse. Besides, the effect of MBCT was moderated by number of prior episodes and MBCT might only be effective for MDD patients with 3 or more previous episodes. Further exploration for the influence of previous psychological intervention is required.

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Antidepressant Monotherapy vs Sequential Pharmacotherapy and Mindfulness-Based Cognitive Therapy, or Placebo, for Relapse Prophylaxis in Recurrent Depression

Segal¹,

Bieling²,

Young³

et al. 2010

Arch Gen Psychiatry

Self Cite

367

298

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Context Mindfulness Based Cognitive Therapy (MBCT) is a group-based psychosocial intervention designed to enhance self-management of prodromal symptoms associated with depressive relapse. Objective To compare rates of relapse in remitted depressed patients receiving MBCT against maintenance antidepressant pharmacotherapy, the current standard of care Design Patients who met remission criteria following 8 months of algorithm informed antidepressant treatment were randomized to either: Maintenance Antidepressant Medication (M-ADM), MBCT or placebo (PLA) and were followed for 18 months. Setting Outpatient clinics at the Centre for Addiction and Mental Health, Toronto and St. Joseph’s Healthcare, Hamilton. Participants One hundred sixty patients aged 18 to 65 meeting DSM-IV for major depressive disorder with a minimum of 2 past episodes. Of these, 84 achieved remission (52.5%) and were assigned to one of the 3 study conditions. Interventions Remitted patients either discontinued their antidepressants and attended eight weekly group sessions of MBCT, continued on their therapeutic dose of antidepressant medication or discontinued active medication onto placebo. Main Outcome Measure Relapse was defined as a return, for at least 2 weeks, of symptoms sufficient to meet the criteria for major depression on Module A of the SCID. Results Intention to treat analyses revealed a significant interaction between the quality of acute phase remission and subsequent prevention of relapse in randomized patients (p = .03). Among unstable remitters (defined as 1 or more HRSD >7 during remission) patients in both MBCT and M-ADM showed a 73% decrease in hazard compared to PLA (p = .03), whereas for stable remitters (all HRSD ≤ 7 during remission) there were no group differences in survival. Findings remained significant after accounting for the effects of past depressive episodes on relapse. Conclusion For depressed patients who are unwilling or unable to tolerate long term maintenance antidepressant treatment, MBCT offers equivalent protection from relapse.

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Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy.

Cited by 2,422 publications

References 29 publications

Internet-based instructor-led mindfulness for work-related rumination, fatigue, and sleep: Assessing facets of mindfulness as mechanisms of change. A randomized waitlist control trial.

Internet-based instructor-led mindfulness for work-related rumination, fatigue, and sleep: Assessing facets of mindfulness as mechanisms of change. A randomized waitlist control trial.

One-year outcomes of a randomized clinical trial treating depression in low-income minority women.

Antidepressant Monotherapy vs Sequential Pharmacotherapy and Mindfulness-Based Cognitive Therapy, or Placebo, for Relapse Prophylaxis in Recurrent Depression

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