Prevention of recurrent bleeding from varicose veins of the esophagus and stomach among patients with decompensated liver cirrhosis

Онницев, И. Е.; Bugaev, Sergey A.; Ivanusa, Sergey Y.; Дзидзава, И. И.; Khokhlov, A V; Котив, Б. Н.

doi:10.17816/kmj2019-333

Cited by 5 publications

(3 citation statements)

References 6 publications

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“…В зависимости от уровня препятствия току крови различают подпечёночную, внутрипечёночную, надпечёночную портальную гипертензию [5,6]. Очевидно, способы моделирования для каждого из этих вариантов свои, однако, в плане технической сложности они не равнозначны.…”

Section: результатыunclassified

Method for increasing scientific value of portal hypertension modeling experiment

Федосеев

Budarev

Chekushin

2023

jour

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Aim: development and testing of a technically simple method for the formation of portal hypertension in the body of a domestic pig, which makes it possible to obtain a model that is close in key parameters to humans. Materials and methods. The material of the study was the results of an experiment conducted in the vivarium of the Ryazan State Medical University on 12 domestic pigs. Results. A method for modeling portal hypertension in the body of a domestic pig by dosed compression of the hepatoduodenal ligament with a plastic clamp was developed and tested. Conclusions. A model of portal hypertension was obtained, which makes it possible to obtain scientific data easily extended to humans, due to the similarity of the anatomy, physiology, and size of the used laboratory animal with those of humans.

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Section: результатыunclassified

Method for increasing scientific value of portal hypertension modeling experiment

Федосеев

Budarev

Chekushin

2023

jour

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“…Наряду с этим диагностическая программа должна включать обследование верхних отделов желудочно-кишечного тракта (ЖКТ) [20][21][22][23]. Дифференциальная диагностика требует исключения в качестве причины кровотечения (опухоли или полипа толстой кишки, язвенного, инфекционного или ишемического колита, болезни Крона, ангиодисплазии, ятрогенных причин предшествующая биопсия или полипэктомия), геморроя [4,13,20].…”

Section: клинические исследованияunclassified

Special aspects of intensive care of patients with complicated diverticulosis of the colon

Shah¹,

Abdulaev²,

Avdeev³

et al. 2021

Bulletin of the Russian Military Medical Academy

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This study presented examination and treatment results of 129 patients with bleeding from the lower gastrointestinal tract who were treated at the Alexandrovskaya Hospital of St. Petersburg in the period from 2012 to 2017. Examination and treatment were performed in the intensive care unit following current clinical guidelines, taking into account the identified concomitant diseases. Endoscopic examination of the colon is the main diagnostic method for the pathological processes that caused bleeding from the lower gastrointestinal tract. Conservative therapy has been demonstrated effectiveness, and urgent surgical treatment was not needed. The main drug therapy included antifibrinolytic drugs and fresh-frozen plasma preparations. Continuous parenteral administration of proteolysis inhibitors was mandatory. Intensive therapy included correction of hemodynamic disturbances and respiratory failure and restoration of the volume of the circulating blood and plasma. Such an approach was found to be 90% effective. In patients with diverticular disease, bleeding from the colonic diverticula develops in one-third of cases. However, if additional risk factors are present, their frequency reaches 50%, often causing death. Continuous or recurrent bleeding is an indication of surgery. In our study, the conservative method of stopping bleeding from the colonic diverticula was possible in all cases. In general, the disease correlated with the age of the patients. In 68 (53%) patients, bleeding occurred despite anticoagulant or antiplatelet therapy. Patients with bleeding from colonic diverticula do not require urgent surgical intervention, and these patients may require admission to the intensive care unit. Intensive care should include the provision of antifibrinolytic drugs, proteolysis inhibitors, and fresh-frozen plasma.

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“…Currently, endoscopic hemostasis is the method of choice in the treatment of patients with bleeding from esophageal varices (EV) (1,2). Endoscopic ligation of esophageal varices (EVL) with latex rings developed by G.V.…”

Section: Introductionmentioning

confidence: 99%

Complications of endoscopic ligation of varicose veins in patients with portal hypertension

Bebezov,

Abdykadyrov

2023

HVT

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The aim of the investigation is to analyze the results of endoscopic varicose vein ligation (EVL) in patients with portal hypertension; to estimate the character and frequency of early and late postoperative complications after EVL; to evaluate the possibility of endoscopic ligation at the moment of active bleeding. Methods: This work includes an analysis of 138 procedures for endoscopic ligation of the esophageal varices in 111 patients from 2016 to 2020. Intrahepatic form of portal hypertension was in 90 patients, extrahepatic form -in 21 patients. The total number of interventions performed was divided into 2 groups. In the first group of patients with EVL was performed urgently, and the second group includes patients, if necessary, with targeted prescription and secondary prevention of portal esophageal bleeding. Results: In 74 (53.6%) cases out of 138, different types of complications were detected. There were 2 lethal cases (1.4%). It should be noted that there were no lethal outcomes in second group after EVL, and after urgent operations, the mortality rate was 33.3%. The most critical complication of ligation was the resumption of hemorrhage due to the site of ligation in the early (1-3 days) and late periods after surgery (5-10 days). Conclusion:In this analysis of the studied cases of complications after EVL, the most common complication was pain syndrome and early and late bleeding were also identified. We showed that control esophagogastroscopies helped to identify bleeding recurrences; examination algorithms in case of detection of bleeding complication after EVL, and measures to prevent the development of recurrent hemorrhage were also necessary.

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Prevention of recurrent bleeding from varicose veins of the esophagus and stomach among patients with decompensated liver cirrhosis

Cited by 5 publications

References 6 publications

Method for increasing scientific value of portal hypertension modeling experiment

Method for increasing scientific value of portal hypertension modeling experiment

Special aspects of intensive care of patients with complicated diverticulosis of the colon

Complications of endoscopic ligation of varicose veins in patients with portal hypertension

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