Prevention of Recurrent Acute Otitis Media in Children Through the Use of Lactobacillus salivarius PS7, a Target-Specific Probiotic Strain

Cárdenas, Nívia; Martín, Virginia; Arroyo, Rebeca; López, Mario; Carrera, Marta; Badiola, Carlos; Jiménez, Esther; Rodríguez, Juan M.

doi:10.3390/nu11020376

Cited by 28 publications

(18 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pertinent to the pandemic affecting adults more than children, these positive findings were confirmed in an RCT that included 27 elderly subjects receiving Bifidobacterium longum or placebo (19). Furthermore, lactic acid bacteria, from which many probiotics are selected, are part of the upper respiratory tract microbiota in healthy people, and some strains are being considered for prevention of recurrent otitis media (20,21). This makes their use for contributing to slow down progression of the coronavirus pandemic worthy of consideration.…”

Section: Clinical Data Supporting the Use Of Probiotics To Prevent Comentioning

confidence: 86%

Using Probiotics to Flatten the Curve of Coronavirus Disease COVID-2019 Pandemic

Baud

Agri

Gibson

et al. 2020

Front. Public Health

202

212

View full text Add to dashboard Cite

Section: Clinical Data Supporting the Use Of Probiotics To Prevent Comentioning

confidence: 86%

Using Probiotics to Flatten the Curve of Coronavirus Disease COVID-2019 Pandemic

Baud

Agri

Gibson

et al. 2020

Front. Public Health

202

212

View full text Add to dashboard Cite

“…The human milk microbiota may contribute to, at least, some of the functional properties and health benefits that epidemiological studies have associated with breastfeeding (Renfrew et al, 2012), including protection against infections, metabolic programming, immunomodulation and neuromodulation. Human milk bacteria may provide a certain degree of protection against infections caused by viruses, bacteria or fungi through a variety of mechanisms: (a) biosynthesis of compounds with antimicrobial activity, including organic acids (lactic acid, acetic acid, ethanol), bacteriocins, reuterin or hydrogen peroxide (Heikkilä and Saris, 2003;Beasley and Saris, 2004;Martıń et al, 2005;Martıń et al, 2006;Caŕdenas et al, 2016;Caŕdenas et al, 2019;Angelopoulou et al, 2020;Garcıá-Gutierrez et al, 2020); (b) coaggregation with pathobionts, impeding their access to the gut epithelial cells (Caŕdenas et al, 2019); (c) competitive exclusion with pathobionts for nutrients or host receptors (Olivares et al, 2006a;Martıń et al, 2010;Langa et al, 2012); (d) reinforcement of the infant gut barrier by preserving and decreasing intestinal permeability and increasing mucin biosynthesis (Olivares et al, 2006a;Vanhaecke et al, 2017;Liu et al, 2020); and (e) inmmunomodulation (Liu et al, 2020).…”

Section: Moving From Composition To Functionmentioning

confidence: 99%

The Microbiota of the Human Mammary Ecosystem

Fernández

Pannaraj

Rautava

et al. 2020

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Human milk contains a dynamic and complex site-specific microbiome, which is not assembled in an aleatory way, formed by organized microbial consortia and networks. Presence of some genera, such as Staphylococcus, Streptococcus, Corynebacterium, Cutibacterium (formerly known as Propionibacterium), Lactobacillus, Lactococcus and Bifidobacterium, has been detected by both culture-dependent and culture-independent approaches. DNA from some gut-associated strict anaerobes has also been repeatedly found and some studies have revealed the presence of cells and/or nucleic acids from viruses, archaea, fungi and protozoa in human milk. Colostrum and milk microbes are transmitted to the infant and, therefore, they are among the first colonizers of the human gut. Still, the significance of human milk microbes in infant gut colonization remains an open question. Clinical studies trying to elucidate the question are confounded by the profound impact of non-microbial human milk components to intestinal microecology. Modifications in the microbiota of human milk may have biological consequences for infant colonization, metabolism, immune and neuroendocrine development, and for mammary health. However, the factors driving differences in the composition of the human milk microbiome remain poorly known. In addition to colostrum and milk, breast tissue in lactating and non-lactating women may also contain a microbiota, with implications in the pathogenesis of breast cancer and in some of the adverse outcomes associated with breast implants. This and other open issues, such as the origin of the human milk microbiome, and the current limitations and future prospects are addressed in this review.

show abstract

“…Another antimicrobial defense mechanism attributed to some intestinal or vaginal lactobacilli is the production of peroxide hydrogen, a compound that is toxic for catalase-negative bacteria, such as streptococci [75]. The production of this compound by L. salivarius has already been reported [59,76,77]. In our study, L. salivarius CECT 9145 (the strain that showed the highest anti-GBS activity) produced high amounts of lactic acid and, in addition, was able to produce peroxide hydrogen.…”

Section: Discussionmentioning

confidence: 99%

Rectal and Vaginal Eradication of Streptococcus agalactiae (GBS) in Pregnant Women by Using Lactobacillus salivarius CECT 9145, A Target-specific Probiotic Strain

et al. 2019

Self Cite

View full text Add to dashboard Cite

Streptococcus agalactiae (Group B Streptococci, GBS) can cause severe neonatal sepsis. The recto-vaginal GBS screening of pregnant women and intrapartum antibiotic prophylaxis (IAP) to positive ones is one of the main preventive options. However, such a strategy has some limitations and there is a need for alternative approaches. Initially, the vaginal microbiota of 30 non-pregnant and 24 pregnant women, including the assessment of GBS colonization, was studied. Among the Lactobacillus isolates, 10 Lactobacillus salivarius strains were selected for further characterization. In vitro characterization revealed that L. salivarius CECT 9145 was the best candidate for GBS eradication. Its efficacy to eradicate GBS from the intestinal and vaginal tracts of pregnant women was evaluated in a pilot trial involving 57 healthy pregnant women. All the volunteers in the probiotic group (n = 25) were GBS-positive and consumed ~9 log10 cfu of L. salivarius CECT 9145 daily from week 26 to week 38. At the end of the trial (week 38), 72% and 68% of the women in this group were GBS-negative in the rectal and vaginal samples, respectively. L. salivarius CECT 9145 seems to be an efficient method to reduce the number of GBS-positive women during pregnancy, decreasing the number of women receiving IAP during delivery.

show abstract

Prevention of Recurrent Acute Otitis Media in Children Through the Use of Lactobacillus salivarius PS7, a Target-Specific Probiotic Strain

Cited by 28 publications

References 72 publications

Using Probiotics to Flatten the Curve of Coronavirus Disease COVID-2019 Pandemic

Using Probiotics to Flatten the Curve of Coronavirus Disease COVID-2019 Pandemic

The Microbiota of the Human Mammary Ecosystem

Rectal and Vaginal Eradication of Streptococcus agalactiae (GBS) in Pregnant Women by Using Lactobacillus salivarius CECT 9145, A Target-specific Probiotic Strain

Contact Info

Product

Resources

About