Prevention of radiation‐induced xerostomia by submandibular gland transfer

Zhang, Ye; Guo, Chuan Bin; Zhang, Lei; Wang, Yan; Peng, Xin; Mao, Chi; Yu, Guang‐Yan

doi:10.1002/hed.21859

Cited by 35 publications

(34 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Current strategies that prevent radiation-induced salivary gland dysfunction include the use of protective medication, such as amifostine or pilocarpine (24, 27, 120), surgical relocation of the submandibular gland (215), and minimization of the radiation dose administered to the major salivary glands (43,62,153,203,206). Although intensity-modulated radiotherapy has provided a significant reduction of xerostomia, 40% of patients still develop life-long complaints (62).…”

Section: Stem Cell Therapy To Ameliorate Radiation-induced Xerostomiamentioning

confidence: 99%

Stem Cell Therapies for the Treatment of Radiation-Induced Normal Tissue Side Effects

Benderitter

Caviggioli

Chapel

et al. 2014

Antioxidants & Redox Signaling

View full text Add to dashboard Cite

Significance: Targeted irradiation is an effective cancer therapy but damage inflicted to normal tissues surrounding the tumor may cause severe complications. While certain pharmacologic strategies can temper the adverse effects of irradiation, stem cell therapies provide unique opportunities for restoring functionality to the irradiated tissue bed. Recent Advances: Preclinical studies presented in this review provide encouraging proof of concept regarding the therapeutic potential of stem cells for treating the adverse side effects associated with radiotherapy in different organs. Early-stage clinical data for radiation-induced lung, bone, and skin complications are promising and highlight the importance of selecting the appropriate stem cell type to stimulate tissue regeneration. Critical Issues: While therapeutic efficacy has been demonstrated in a variety of animal models and human trials, a range of additional concerns regarding stem cell transplantation for ameliorating radiationinduced normal tissue sequelae remain. Safety issues regarding teratoma formation, disease progression, and genomic stability along with technical issues impacting disease targeting, immunorejection, and clinical scale-up are factors bearing on the eventual translation of stem cell therapies into routine clinical practice. Future Directions: Follow-up studies will need to identify the best possible stem cell types for the treatment of early and late radiation-induced normal tissue injury. Additional work should seek to optimize cellular dosing regimes, identify the best routes of administration, elucidate optimal transplantation windows for introducing cells into more receptive host tissues, and improve immune tolerance for longer-term engrafted cell survival into the irradiated microenvironment. Antioxid. Redox Signal. 21, 338-355.

show abstract

Section: Stem Cell Therapy To Ameliorate Radiation-induced Xerostomiamentioning

confidence: 99%

Stem Cell Therapies for the Treatment of Radiation-Induced Normal Tissue Side Effects

Benderitter

Caviggioli

Chapel

et al. 2014

Antioxidants & Redox Signaling

View full text Add to dashboard Cite

show abstract

“…After having read the full texts, it was found that there were 12 articles which could be summarized based on the authors, sample source, sample size, allocation and interventions in the groups; i.e., the study by Jha et al [43] and Seikaly et al [44] were considered as one study, the study by Jha et al [31], Jha et al [45] and Rieger et al [46] were considered as one study, and the studies by Liu et al [47,48,49] were viewed as one study. Finally, only 7 studies (12 articles) fulfilled the final inclusion criteria and were included in the present systematic review [31,43,44,45,46,47,48,49,50,51,52,53,54]. No trials were found during gray literature search.…”

Section: Resultsmentioning

confidence: 99%

“…One debate was about the reason why the incidence of postradiation xerostomia differed in various reports, with acute postradiation xerostomia ranging from 64.7 [43] to 100% [53] and late postradiation xerostomia from 65.8 [45 ]to 100% [53]. This difference might have been caused by different total radiation doses, different follow-up periods used, objective and subjective methods in measurement, different races or even the different medical levels in various countries, which most likely influence the incidence and degree of radiation-induced xerostomia.…”

Section: Discussionmentioning

confidence: 99%

“…As early as 1911, Bergonie [57], a French radiobiologist, was the first to describe that radiotherapy destroyed the salivary function and caused eating difficulty. However, for 100 years, the discussions about postradiation xerostomia have never disappeared, although the definition and pathogenesis of postradiation xerostomia have already been accepted, and the prevention of postradiation xerostomia by transferring the submandibular gland into the submental space has become popular [10,25,31,32,37,38,43,44,45,46,47,48,49,50,51,52,53]. …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Submandibular Gland Transfer for the Prevention of Postradiation Xerostomia in Patients with Head and Neck Cancer: A Systematic Review and Meta-Analysis

Wu¹,

Weng²,

Li³

et al. 2015

ORL

View full text Add to dashboard Cite

Background: Submandibular gland transfer has been widely used to prevent postradiation xerostomia in head-and-neck cancers. However, there are still some controversies. Methods: Six databases were searched, data extraction was performed and the risk of bias was assessed by 2 reviewers independently. The meta-analysis was performed using Review Manager, version 5.2. Results: A total of 7 trials (12 articles) and 369 participants were included. Conclusions: The present clinical evidence suggests that submandibular gland transfer might be highly effective to prevent postradiation xerostomia in head-and-neck cancers without serious adverse events. However, more randomized controlled trials are still needed to confirm this conclusion.

show abstract

“…Second, some studies have suggested that the submandibular glands, rather than the parotid glands, are the relevant OARs for xerostomia. 33 As most prior studies on anatomic changes during radiotherapy have focused on the GTV and parotid, we similarly focused on these targets for the purposes of comparative analysis. In future work, we will examine dosimetric changes to the submandibular gland as well.…”

Section: Discussionmentioning

confidence: 99%

Anatomic and dosimetric changes in patients with head and neck cancer treated with an integrated MRI-tri-⁶⁰Co teletherapy device

Raghavan

Kishan

Cao

et al. 2016

BJR

View full text Add to dashboard Cite

Objective: Prior studies have relied on CT to assess alterations in anatomy among patients undergoing radiation for head and neck cancer. We sought to determine the feasibility of using MRI-based image-guided radiotherapy to quantify these changes and to ascertain their potential dosimetric implications. Methods: 6 patients with head and neck cancer were treated with intensity-modulated radiotherapy (IMRT) on a novel tri- 60Co teletherapy system equipped with a 0.35-T MRI (VR, ViewRay Incorporated, Oakwood Village, OH) to 66-70 Gy in 33 fractions (fx). Pre-treatment MRIs on Fx 1, 5, 10, 15, 20, 25, 30 and 33 were imported into a contouring interface, where the primary gross tumour volume (GTV) and parotid glands were delineated. The centre of mass (COM) shifts for these structures were assessed relative to Day 1. Dosimetric data were co-registered with the MRIs, and doses to the GTV and parotid glands were assessed.Results: Primary GTVs decreased significantly over the course of IMRT (median % volume loss, 38.7%; range, 29.5-72.0%; p , 0.05) at a median rate of 1.2%/ fx (range, 0.92-2.2%/fx). Both the ipsilateral and contralateral parotid glands experienced significant volume loss (p , 0.05, for all) and shifted medially during IMRT. Weight loss correlated significantly with parotid gland volume loss and medial COM shift (p , 0.05). Conclusion: Integrated on-board MRI can be used to accurately contour and analyze primary GTVs and parotid glands over the course of IMRT. COM shifts and significant volume reductions were observed, confirming the results of prior CT-based exercises. Advances in knowledge: The superior resolution of onboard MRI may facilitate online adaptive replanning in the future.

show abstract

Prevention of radiation‐induced xerostomia by submandibular gland transfer

Cited by 35 publications

References 42 publications

Stem Cell Therapies for the Treatment of Radiation-Induced Normal Tissue Side Effects

Stem Cell Therapies for the Treatment of Radiation-Induced Normal Tissue Side Effects

Submandibular Gland Transfer for the Prevention of Postradiation Xerostomia in Patients with Head and Neck Cancer: A Systematic Review and Meta-Analysis

Anatomic and dosimetric changes in patients with head and neck cancer treated with an integrated MRI-tri-⁶⁰Co teletherapy device

Contact Info

Product

Resources

About

Prevention of radiation‐induced xerostomia by submandibular gland transfer

Cited by 35 publications

References 42 publications

Stem Cell Therapies for the Treatment of Radiation-Induced Normal Tissue Side Effects

Stem Cell Therapies for the Treatment of Radiation-Induced Normal Tissue Side Effects

Submandibular Gland Transfer for the Prevention of Postradiation Xerostomia in Patients with Head and Neck Cancer: A Systematic Review and Meta-Analysis

Anatomic and dosimetric changes in patients with head and neck cancer treated with an integrated MRI-tri-60Co teletherapy device

Contact Info

Product

Resources

About

Anatomic and dosimetric changes in patients with head and neck cancer treated with an integrated MRI-tri-⁶⁰Co teletherapy device