Prevention of pruritus with ethyl-chloride in skin prick test: a double-blind placebo-controlled prospective study

Gal‐Oz, Amir; Kivity, Shmuel; Shacham, Yacov; Fiszer, Elisheva; Rogowsky, Ori; Chernin, Gil

doi:10.1186/s13223-015-0091-z

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…Other agents that have been promoted as having a topical antipruritic effect in double-blind RCTs include the topical anaesthetic spray ethyl chloride in placebo-controlled studies, 230,231 the topical tricyclic antidepressants amitriptyline and diphenhydramine, compared with vehicle control 232 and the moderate-potency topical steroid clobetasone butyrate. 233 Only clobetasone butyrate and hydrocortisone are available for over-the-counter use in the U.K.…”

Section: Topical Treatments For Generalized Pruritus Of Unknown Originmentioning

confidence: 99%

British Association of Dermatologists’ guidelines for the investigation and management of generalized pruritus in adults without an underlying dermatosis, 2018

Millington¹,

Collins²,

Lovell³

et al. 2018

Br J Dermatol

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SummaryPruritus (or itch) is a common and distressing symptom of many skin diseases, systemic illnesses and psychological disorders. Itch is perhaps the commonest presenting symptom of skin disorders. In any two week period, 8 to 9% of the population suffer from significant pruritus. The focus of this guideline is not itchy rashes, but rather the situation where itch is present without rash. The guidelines also do not cover itch in children, in pregnancy, nor do they detail the science of the cause of itch. The study group consist mostly of dermatologists (skin specialists) from a number of hospitals in the U.K., but a number of other hospital doctors, a nurse and a general practitioner (GP) are also part of the team. There may be an underlying cause of pruritus, such as blood disorders, iron deficiency or excess, kidney problems, liver problems, cancer, infections, medications, behavioural factors, dry skin or any combination of these with old age. This can be significant in 20 to 30% of cases of itchy skin without rash. There remain a small number of individuals with itch and no apparent underlying cause or rash. It is always important to look for an underlying causative condition, as the most effective management of pruritus without rash depends on the treatment of any underlying disease. The management of itch appears to be very situation specific, even if the underlying cause cannot be treated. The management of true pruritus of unknown cause is different again.

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Section: Topical Treatments For Generalized Pruritus Of Unknown Originmentioning

confidence: 99%

British Association of Dermatologists’ guidelines for the investigation and management of generalized pruritus in adults without an underlying dermatosis, 2018

Millington¹,

Collins²,

Lovell³

et al. 2018

Br J Dermatol

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“…Інші агенти, які виявили місцеву протисвербіжну дію, включають місцевий анестетичний спрей етилхлорид у контрольованих плацебо-дослідженнях [27,28], місцеві трициклічні антидепресанти амітриптилін та дифенгідрамін, порівняно з контрольним засобом [29], та середній по дії місцевий стероїдний препарат клобетазону бутират [30].…”

Section: місцеві методи лікування генералізованого свербежу невідомого походження (Gpuo)unclassified

Itching as the onset of pain (part 3)

Kushnir

Dmytrenko

Katilov

et al. 2020

PMJUA

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Itchy skin is an extremely unpleasant symptom that can provoke insomnia, depression, irritability, loss of appetite. There are several theories of itching. According to one of them, itching is a modified pain caused by a slight irritation of the nerve endings in the skin. According to the second, itching is an independent symptom, in the formation of which nervous, humoral and vascular mechanisms are involved. Other theories consider itching as a reaction of the autonomic nervous system or a hereditary pathological condition. According to recent studies, itchy skin is characterized by the absence of a universal peripheral mediator of itching. The trigger for itching is the action of pruritogen – a mechanical, chemical, thermal or electrical stimulant directly or indirectly through mediators. Free ends of type A delta fibers and type C fibers play a crucial role in itching and pain. If this was previously confirmed only by clinical observations, now there are neurophysiological studies that support the theory that itching and pain fibers are one with different activity thresholds. Today, it is unacceptable that there are separate specific receptors for different sensations. It is now assumed that there are mixed receptors for heat, cold, pain, itching and touch [95]. Systematic use of substances included in the list of drugs and manifested by mental and physical dependence on them – drug addiction, one of the diseases of society. But drug addiction is sometimes forced, according to medical indications, in cases of palliative conditions. Depending on the stage of the person after taking the drug or in the interval between drug use, one of the signs of use may be severe itching of the skin. And after excluding both the main diseases that cause itching and other secondary causes of itching, it can be assumed that a person has idiopathic generalized pruritus (itching) of unknown origin (GPOU). The itching of the elderly, which is quite common in the elderly, as a manifestation of concomitant, often combined, somatic pathology, but may also be due to physiological changes, both on the skin and on the physiological aging of nerve endings.

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“…Other agents that have been promoted as having a topical antipruritic effect in double‐blind RCTs include the topical anaesthetic spray ethyl chloride in placebo‐controlled studies, the topical tricyclic antidepressants amitriptyline and diphenhydramine, compared with vehicle control and the moderate‐potency topical steroid clobetasone butyrate . Only clobetasone butyrate and hydrocortisone are available for over‐the‐counter use in the U.K.…”

Section: Treatment Of Generalized Pruritus Of Unknown Originmentioning

confidence: 99%

British Association of Dermatologists’ guidelines for the investigation and management of generalized pruritus in adults without an underlying dermatosis, 2018

et al. 2018

View full text Add to dashboard Cite

show abstract

Prevention of pruritus with ethyl-chloride in skin prick test: a double-blind placebo-controlled prospective study

Cited by 3 publications

References 19 publications

British Association of Dermatologists’ guidelines for the investigation and management of generalized pruritus in adults without an underlying dermatosis, 2018

British Association of Dermatologists’ guidelines for the investigation and management of generalized pruritus in adults without an underlying dermatosis, 2018

Itching as the onset of pain (part 3)

British Association of Dermatologists’ guidelines for the investigation and management of generalized pruritus in adults without an underlying dermatosis, 2018

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