Prevention of Postoperative Wound Infections

Andersen, Bjørg Marit

doi:10.1007/978-3-319-99921-0_33

Cited by 34 publications

(30 citation statements)

References 177 publications

(330 reference statements)

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“…For instance, in a Serbian study, M. chlonae was detected in bronchoscopes used in pediatric patients. M. fortuitum was the causative agent for endocarditis in three heart-operated Serb children, attributed to the bovine pericardial patches that were used for ventricular septal defects [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

A Saudi Arabian Public Health Perspective of Tuberculosis

Saati

Khurram

Faidah

et al. 2021

IJERPH

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Tuberculosis is a global health challenge due to its spreading potential. The Kingdom of Saudi Arabia (KSA) faces a challenge in the spread of tuberculosis from migrant workers, but the foremost threat is the huge number of pilgrims who travel to visit sacred sites of the Islamic world located in the holy cities of Makkah and Al Madina. Pilgrims visit throughout the year but especially in the months of Ramadan and Zul-Hijah. The rise of resistance in Mycobacterium tuberculosis is an established global phenomenon that makes such large congregations likely hotspots in the dissemination and spread of disease at a global level. Although very stringent and effective measures exist, the threat remains due to the ever-changing dynamics of this highly pathogenic disease. This overview primarily highlights the current public health challenges posed by this disease to the Saudi health system, which needs to be highlighted not only to the concerned authorities of KSA, but also to the concerned global quarters since the pilgrims and migrants come from all parts of the world with a majority coming from high tuberculosis-burdened countries.

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Section: Introductionmentioning

confidence: 99%

A Saudi Arabian Public Health Perspective of Tuberculosis

Saati

Khurram

Faidah

et al. 2021

IJERPH

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“…Various agents, including films, gels, and other substances, have been used as physical shelters for segregating injured tissues during the healing process. 10 , 11 Compared to these agents, the tailorable porosity and pore size of nanofibrous membranes allow them to mimic the extracellular matrix (ECM) to promote cell proliferation. 25 The large surface-to-volume ratio of electrospun nanofibers also offers a considerable number of bioactive agent binding sites, making it a promising candidate for multiple biomedical applications, including anti-adhesive membranes.…”

Section: Discussionmentioning

confidence: 99%

“…Postoperative wound infection is a common problem that can lead to pain, impaired wound healing, the requirement for prolonged antibiotic use, reoperation, extended hospitalization, and elevated health care costs. 11 It has been reported that the development of surgical site infection depends on the type of operation and may arise in 5–20% of operations, leading to 7 to 11 additional post-surgical days of hospitalization and 2- to 11-times higher risk of mortality than in non-infected patients. 12 Pain that occurs after an operation is a significant concern.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Antimicrobial Agents, Analgesics, and Epidermal Growth Factors-Embedded Anti-Adhesive Poly(Lactic-Co-Glycolic Acid) Nanofibrous Membranes: In vitro and in vivo Studies

Liu¹,

Kao²,

Tseng³

et al. 2021

IJN

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Background Postoperative tissue adhesion is a major concern for most surgeons and is a nearly unpreventable complication after abdominal or pelvic surgeries. This study explored the use of sandwich-structured antimicrobial agents, analgesics, and human epidermal growth factor (hEGF)-incorporated anti-adhesive poly(lactic-co-glycolic acid) nanofibrous membranes for surgical wounds. Materials and Methods Electrospinning and co-axial electrospinning techniques were utilized in fabricating the membranes. After spinning, the properties of the prepared membranes were assessed. Additionally, high-performance liquid chromatography and enzyme-linked immunosorbent assays were utilized in assessing the in vitro and in vivo liberation profiles of the pharmaceuticals and the hEGF from the membranes. Results The measured data suggest that the degradable anti-adhesive membranes discharged high levels of vancomycin/ceftazidime, ketorolac, and hEGF in vitro for more than 30, 24, and 27 days, respectively. The in vivo assessment in a rat laparotomy model indicated no adhesion in the peritoneal cavity at 14 days post-operation, demonstrating the anti-adhesive capability of the sandwich-structured nanofibrous membranes. The nanofibers also released effective levels of vancomycin, ceftazidime, and ketorolac for more than 28 days in vivo. Histological examination revealed no adverse effects. Conclusion The outcomes of this study implied that the anti-adhesive nanofibers with sustained release of antimicrobial agents, analgesics, and growth factors might offer postoperative pain relief and infection control, as well as promote postoperative healing of surgical wounds.

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“…Wound hygiene is predictive of infection (18) (19). So far we could not nd in the current literature mention of wound hygiene classi cation after pilonidal sinus disease surgery.…”

Section: Discussionmentioning

confidence: 99%

Sacro-coxxygial hygiene, a Key Factor in the Outcome of Pilonidal Sinus surgical treatment ?

Dupuis

Christou

Teterycz

et al. 2021

Preprint

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Background Surgical wound infection contributes to prolonged recovery time after pilonidal sinus excision. As a standard procedure after surgery, we recommend our patients to perform water irrigations in the intergluteal cleft 4 to 6 times a day during the post-operative period. Our hypothesis is that this should reduce healing time and complication rates. The aim of this study was to measure the importance of sacro coccygeal hygiene in the management of pilonidal sinus disease. Methods We retrospectively collected data after surgical management of pilonidal sinus (sinusectomy procedures) in our division over a ten-year period. Patients were divided into three groups according to their local hygiene during postoperative follow-up and scored one (G1: good hygiene) to three (G3: poor hygiene). Primary outcome was complication rates. Secondary endpoints were, healing time, follow-up, time off work, and recurrence rate. Results In G1 (N = 112), complication rate was 3.6%. In G2 (N = 109), it was 5.5%, whereas in G3 (N = 71), it reached 7.03%. However, there were no statistically significant differences between hygiene groups regarding complication rates in both univariate and multivariable analysis. Regarding secondary outcomes, there were significant differences between hygiene groups concerning median follow-up (p = 0.0001) and median time off work (p = 0.0127). Conclusion Good hygiene of wound is essential for optimal, rapid healing without complications. The importance of this report is to show that thanks to our hygiene follow-up strategy with frequent perineal irrigations and regular follow-up checks, patients with at a first glance “unclean local conditions”, reached similar complications, median healing time and recurrences rates to patients with medium and good wound hygiene level

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Prevention of Postoperative Wound Infections

Cited by 34 publications

References 177 publications

A Saudi Arabian Public Health Perspective of Tuberculosis

A Saudi Arabian Public Health Perspective of Tuberculosis

Assessment of Antimicrobial Agents, Analgesics, and Epidermal Growth Factors-Embedded Anti-Adhesive Poly(Lactic-Co-Glycolic Acid) Nanofibrous Membranes: In vitro and in vivo Studies

Sacro-coxxygial hygiene, a Key Factor in the Outcome of Pilonidal Sinus surgical treatment ?

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