Prevention of postoperative swelling and pain by dexamethasone after operative removal of impacted third molar teeth

Schmelzeisen, Rainer; Jc, Frölich

doi:10.1007/bf00271371

Cited by 77 publications

(49 citation statements)

References 17 publications

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“…3 Thoracic epidural analgesia with morphine-bupivacaine combination improves analgesia in the first 24 hr following laparoscopic cholecystectomy. 4 Preoperative administration of dexamethasone by oral 5,6 and iv 7,8 routes has been shown to reduce overall pain scores and analgesic requirements in the postoperative period without any apparent adverse effect. Wang et al 9 showed that epidural administration of dexamethasone reduces the incidence and severity of …”

Section: Discussionmentioning

confidence: 99%

“…3 Thoracic epidural analgesia with morphine-bupivacaine combination improves pain relief during the first 24 hr following laparoscopic cholecystectomy. 4 Preoperative administration of dexamethasone has been reported to reduce postoperative pain through both oral 5,6 and iv 7,8 routes of administration. While epidural steroids are effective in the treatment of low back pain, 9 their potential postoperative analgesic benefits have not been evaluated.…”

Section: B Enefits Of Laparoscopic Cholecystectomymentioning

confidence: 99%

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L’administration péridurale de dexaméthasone réduit la douleur et la demande d’analgésiques postopératoires

Thomas

Beevi

2006

Can J Anesth/J Can Anesth

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Purpose: Epidural steroids may have potential advantages for providing postoperative analgesia. We therefore undertook a study to evaluate the efficacy of epidurally administered dexamethasone in reducing postoperative morphine requirements, as a measure of analgesia following laparoscopic cholecystectomy. Methods:In a randomized, double-blind study, 94 patients undergoing laparoscopic cholecystectomy were randomly assigned to one of three groups. Group 1 (Control) patients received dexamethasone 5 mg iv with epidural injection of 0.25% bupivacaine 8 mL and normal saline 2 mL, Group 2 (D1) patients received normal saline 2 mL iv with epidural injection of 0.25% bupivacaine 8 mL and dexamethasone 5 mg in normal saline 2 mL, and Group 3 (D2) patients received normal saline 2 mL iv with epidural injection of dexamethasone 5 mg in normal saline 10 mL. After surgery, morphine 2-4 mg iv was administered as needed for analgesia. Postoperative morphine requirements, visual analogue scale (VAS) pain scores at rest and with effort, and time to first analgesic administration were recorded by a blinded observer. Results:Total morphine consumption for the first 24 hr following surgery was lower in both epidural dexamethasone groups (D1, D2) compared to the control group (P < 0.05). The percentage reduction in morphine consumption in Group D1 was 53.9% and in Group D2 was 52.9% in the first 24 hr. Postoperatively at 12 hr, 18 hr and 24 hr, the VAS scores at rest and during effort were also lower in the epidural dexamethasone groups (D1, D2) compared to the control group (P < 0.05). The percentage reductions in VAS scores with effort at 12 hr, 18 hr and 24 hr in Group D1 were 50%, 52.9% and 50% respectively, and in Group D2 percentage reductions in pain scores with effort were 54.8%, 58.8% and 55.5% at corresponding sampling intervals. Conclusion:Preoperative epidural administration of dexamethasone 5 mg, with or without bupivacaine, reduces postoperative pain and morphine consumption following laparoscopic cholecystectomy. Objectif

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Section: Discussionmentioning

confidence: 99%

Section: B Enefits Of Laparoscopic Cholecystectomymentioning

confidence: 99%

L’administration péridurale de dexaméthasone réduit la douleur et la demande d’analgésiques postopératoires

Thomas

Beevi

2006

Can J Anesth/J Can Anesth

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“…Coxibs were of similar efficacy to nsNSAIDs in acute postoperative dental pain (Chen et Perioperative steroid administration reduced swelling and trismus but not pain, following third molar extraction (Markiewicz et al, 2008 Level I) and reduced postoperative nausea (Baxendale et al, 1993 Level II; Schmelzeisen & Frolich, 1993 Level II).…”

Section: Chaptermentioning

confidence: 98%

Acupuncture for analgesia in the emergency department: a multicentre, randomised, equivalence and non‐inferiority trial

Cohen

Smit

Andrianopoulos³

et al. 2017

Medical Journal of Australia

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Objectives: This study aimed to assess analgesia provided by acupuncture, alone or in combination with pharmacotherapy, to patients presenting to emergency departments with acute low back pain, migraine or ankle sprain. Design: A pragmatic, multicentre, randomised, assessor‐blinded, equivalence and non‐inferiority trial of analgesia, comparing acupuncture alone, acupuncture plus pharmacotherapy, and pharmacotherapy alone for alleviating pain in the emergency department. Setting, participants: Patients presenting to emergency departments in one of four tertiary hospitals in Melbourne with acute low back pain, migraine, or ankle sprain, and with a pain score on a 10‐point verbal numerical rating scale (VNRS) of at least 4. Main outcome measures: The primary outcome measure was pain at one hour (T1). Clinically relevant pain relief was defined as achieving a VNRS score below 4, and statistically relevant pain relief as a reduction in VNRS score of greater than 2 units. Results: 1964 patients were assessed between January 2010 and December 2011; 528 patients with acute low back pain (270 patients), migraine (92) or ankle sprain (166) were randomised to acupuncture alone (177 patients), acupuncture plus pharmacotherapy (178) or pharmacotherapy alone (173). Equivalence and non‐inferiority of treatment groups was found overall and for the low back pain and ankle sprain groups in both intention‐to‐treat and per protocol (PP) analyses, except in the PP equivalence testing of the ankle sprain group. 15.6% of patients had clinically relevant pain relief and 36.9% had statistically relevant pain relief at T1; there were no between‐group differences. Conclusion: The effectiveness of acupuncture in providing acute analgesia for patients with back pain and ankle sprain was comparable with that of pharmacotherapy. Acupuncture is a safe and acceptable form of analgesia, but none of the examined therapies provided optimal acute analgesia. More effective options are needed. Trial registration: Australian New Zealand Clinical Trials Registry, ACTRN12609000989246.

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“…9 Dexamethasone is a potent corticosteroid with analgesic, anti-inflammatory and antiemetic action. [10][11][12] Preoperative dexamethasone has been reported to reduce the incidence of postoperative pain and swelling following oral surgeries. [10][11][12] A previous study undertaken to evaluate the effect of dexamethasone on postoperative sore throat after endotracheal intubation did not address the numerous confounding factors responsible for sore throat.…”

mentioning

confidence: 99%

“…[10][11][12] Preoperative dexamethasone has been reported to reduce the incidence of postoperative pain and swelling following oral surgeries. [10][11][12] A previous study undertaken to evaluate the effect of dexamethasone on postoperative sore throat after endotracheal intubation did not address the numerous confounding factors responsible for sore throat. 13 With this background knowledge, a prospective, randomized, double-blind, placebo-controlled study was undertaken to test whether a reduction in the incidence and severity of postoperative sore throat could be achieved by preoperative administration of intravenous dexamethasone in patients receiving general anesthesia with endotracheal intubation.…”

mentioning

confidence: 99%

Dexamethasone reduces the severity of postoperative sore throat

Thomas

Beevi

2007

Can J Anesth/J Can Anesth

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Purpose: Dexamethasone may have potential advantages in the prevention of postoperative sore throat. We therefore undertook a study to evaluate the efficacy of intravenously administered dexamethasone in reducing the incidence and severity of postoperative sore throat in patients receiving general anesthesia with endotracheal intubation. Methods:In a randomized, double-blind and placebo-controlled study, 120 patients receiving general anesthesia with endotracheal intubation were randomly assigned to two groups. Group 1 (control) patients received normal saline 2 mL iv and group 2 (D) patients received dexamethasone 8 mg iv. After surgery, visual analogue scale (VAS) scores at rest and with effort (swallowing movement) for postoperative sore throat were recorded by a blinded observer. Results:The overall incidence of postoperative sore throat during the first 24 hr following surgery was lower in dexamethasone group (D) compared to the control group (C). Eleven (20%) patients in the dexamethasone group had postoperative sore throat, compared to 31 (56.3%) patients in the control group (P < 0.01). Postoperatively at one hour, three hours, six hours, 12 hr and 24 hr, the VAS scores for postoperative sore throat at rest and during effort were lower in the dexamethasone group (D) compared to the control group (P < 0.01) at corresponding time intervals. Conclusion:Preoperative administration of dexamethasone 8 mg iv reduces the incidence and severity of postoperative sore throat in patients receiving general anesthesia with endotracheal intubation. REPORTS OF ORIGINAL INVESTIGATIONS

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Prevention of postoperative swelling and pain by dexamethasone after operative removal of impacted third molar teeth

Cited by 77 publications

References 17 publications

L’administration péridurale de dexaméthasone réduit la douleur et la demande d’analgésiques postopératoires

L’administration péridurale de dexaméthasone réduit la douleur et la demande d’analgésiques postopératoires

Acupuncture for analgesia in the emergency department: a multicentre, randomised, equivalence and non‐inferiority trial

Dexamethasone reduces the severity of postoperative sore throat

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