Prevention of Postoperative Infection Following Laparoscopic Cholecystectomy. Comparison between Single Dose and 2-day Dose Administration of Antibiotic Prophylaxis.

Meta‐analysis: antibiotic prophylaxis in elective laparoscopic cholecystectomy

“…Sixty eight records were identified by the search strategy; 48 records were excluded because of the reasons shown in Figure 1. Of the 20 potentially appropriate studies, 25–44 three were excluded for comparing two kinds of ABP, 25–27 one for comparing ABP with other intervention, 28 and one for assessing tropical ABP 29 . Finally, 15 RCTs were included in the meta‐analysis (Table 1).…”

Parenteral Fosfomycin in Gastrointestinal Surgery: A Systematic Review

“…The characteristic of the included studies is depicted in ▶table 1. The majority of the included studies were RCTs [16,[20][21][22][23][24][26][27][28], three studies were retrospective cohort studies [19,29,30],…”

“…The characteristic of the included studies is depicted in Table 1 . The majority of the included studies were RCTs 16 20 21 22 23 24 26 27 28 , three studies were retrospective cohort studies 19 29 30 , and three studies were prospective cohort studies 17 18 25 . Nearly half of the studies were carried out in the 1980s to early 1990s 21 22 23 24 25 26 27 .…”

“…1. The nine RCTs [16,[20][21][22][23][24][26][27][28] included were assessed, however, one was a quasi-randomized clinical trial [16], thus resulting in a high risk of bias for the domains' random sequence generation and allocation concealment. For most domains, there was unclear risk of bias in 67 % to 89 % of included RCTs.…”

“…Other sources of bias that were noted concerned conflicts of interest and funding. In total, 88 % of studies had no conflicts of interest statement [20][21][22][23][24][26][27][28]. In most RCTs, a funding statement was either not reported [20,23,24] or had insufficient details on the role of funders and/or drug providers [21,22,[26][27][28].…”