Prevention of polymorphic light eruption by oral administration of a nutritional supplement containing lycopene, β‐carotene, and <i><scp>L</scp>actobacillus johnsonii</i>: results from a randomized, placebo‐controlled, double‐blinded study

Marini, Alessandra; Jaenicke, Thomas; Grether‐Beck, Susanne; Floch, Caroline Le; Cheniti, Ahsène; Piccardi, Nathalie; Krutmann, Jean

doi:10.1111/phpp.12093

Cited by 33 publications

(28 citation statements)

References 12 publications

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“…These results corroborate and extend results from a previous study in which oral supplementation with a nutritional supplement containing TNC, b-carotene and Lactobacillus johnsonii was found to mitigate the development of skin lesions, as well as the concomitant upregulation of ICAM-1 mRNA in UVA1irradiated lesional skin of patients with PLE. 29,30 Taken together, these studies imply that oral photoprotection with selected carotenoids not only provides protection against shortwave UVB/A radiation, but also against longwave UVA1 radiation. The precise mechanism by which lycopene and lutein inhibit UVA1 radiation-induced gene expression is currently not known but most likely involves antioxidative mechanisms.…”

Section: Discussionmentioning

confidence: 83%

“…Biopsies were snap frozen in liquid nitrogen and stored at À80°C until further analysis, which was done as previously described. 29,30 For reverse transcriptase polymerase chain reaction (PCR) analysis of mRNA expression the following primer pairs were used: heme-oxygenase 1 (HO-1; forward 5 0 -CT GCGTTCCT-GCTCAACATC-3 0 , reverse 5 0 -GCAGAATCTTGCAC TTTGTTGCT-3 0 ; 31 matrix metallopeptidase 1 (MMP-1; forward 5 0 -GGGAGATCATCGGGACAACTC-3 0 , reverse 5 0 -GGGCCTGGT T-GAAAAGCAT-3 0 ; 32 intercellular adhesion molecule 1 (ICAM-1; forward 5 0 -CCTGGCACCCAGCACAAT-3 0 , reverse 5 0 -GCCGA TCCACACGGAGTACT-3 0 ); 33 and 18S rRNA as housekeeping gene (forward 5 0 -GCCGCTAGAGGTGAAATTCTTG-3 0 , reverse 5 0 -CATTCTTGGCAAATGCTTTCG-3 0 ). 34 For comparison of relative gene expression in real-time PCR the 2 (ÀDDC(T)) method was used.…”

Section: Assessment Of Gene Expressionmentioning

confidence: 99%

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Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: results from a double-blinded, placebo-controlled, crossover study

et al. 2017

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SummaryBackground Increasing evidence suggests photoprotection by oral supplementation with b-carotene and lycopene. Objectives To examine the capacity of lycopene-rich tomato nutrient complex (TNC) and lutein, to protect against ultraviolet (UV)A/B and UVA1 radiation at a molecular level. Methods In a placebo-controlled, double-blinded, randomized, crossover study two active treatments containing either TNC or lutein were assessed for their capacity to decrease the expression of UVA1 the radiation-inducible genes HO1, ICAM1 and MMP1. Sixty-five healthy volunteers were allocated to four treatment groups and subjected to a 2-week washout phase, followed by two 12-week treatment phases separated by another 2 weeks of washout. Volunteers started either with active treatment and were then switched to placebo, or vice versa. At the beginning and at the end of each treatment phase skin was irradiated and 24 h later biopsies were taken from untreated, UVA/B-and UVA1-irradiated skin for subsequent reverse transcriptase polymerase chain reaction analysis of gene expression. Moreover, blood samples were taken after the washout and the treatment phases for assessment of carotenoids. Results TNC completely inhibited UVA1-and UVA/B-induced upregulation of heme-oxygenase 1, intercellular adhesion molecule 1 and matrix metallopeptidase 1 mRNA, no matter the sequence (ANOVA, P < 0Á05). In contrast, lutein provided complete protection if it was taken in the first period but showed significantly smaller effects in the second sequence compared with TNC. Conclusions Assuming the role of these genes as indicators of oxidative stress, photodermatoses and photoageing, these results might indicate that TNC and lutein could protect against solar radiation-induced health damage.

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Section: Discussionmentioning

confidence: 83%

Section: Assessment Of Gene Expressionmentioning

confidence: 99%

Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: results from a double-blinded, placebo-controlled, crossover study

et al. 2017

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“…19 Similarly, another randomized study, conducted with an association of vitamins A, C, E, selenium, pomegranate extract, quercetin, green tea, coenzyme q10 and carotenoids, such as lutein, lycopene and zeaxanthin, led to an improvement in the erythematous dose and absorption levels of free radicals after 4 weeks of use. 20 …”

Section: The Paradox Of Antioxidants Excessmentioning

confidence: 99%

Antioxidants in dermatology

Addor¹

2017

An. Bras. Dermatol.

108

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The skin cells continuously produce, through cellular respiration, metabolic processes or under external aggressions, highly reactive molecules oxidation products, generally called free radicals. These molecules are immediately neutralized by enzymatic and non-enzymatic systems in a physiological and dynamic balance. In situations where this balance is broken, various cellular structures, such as the cell membrane, nuclear or mitochondrial DNA may suffer structural modifications, triggering or worsening skin diseases. several substances with alleged antioxidant effects has been offered for topical or oral use, but little is known about their safety, possible associations and especially their mechanism of action. The management of topical and oral antioxidants can help dermatologist to intervene in the oxidative processes safely and effectively, since they know the mechanisms, limitations and potential risks of using these molecules as well as the potential benefits of available associations.

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“…A commercially available combination of lycopene 2.5 mg, β-carotene, and Lactobacillus johnsonii 5.10 × 10 8 cfu was the intervention in a 12-week randomized, double-blinded, placebo-controlled trial with 60 patients who had polymorphic light eruptions [ 49 ]. The combination of lycopene 2.5 mg, β-carotene, and L. johnsonii 5.10 × 10 8 cfu was able to reduce the effect of a single exposure to longwave UV radiation (UVA1), p < 0.001, but that of multiple exposures [ 49 ]. UVA1-inducible gene mRNA expression is a surrogate marker for UVA exposure [ 48 , 49 ].…”

Section: Other Supplements—carotenoids Coenzyme Q10 Polyunsaturamentioning

confidence: 99%

Skin Protective Nutraceuticals: The Current Evidence in Brief

Nwanodi¹

2018

Healthcare

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Nutraceuticals are important for healthy skin maintenance. Probiotics, phenolics, and vitamins are just a few of the nutraceuticals meant to potentially prevent and assist medical management of dermatologic conditions. Among these, probiotics, vitamin E, and green tea catechins may offer the broadest array of skin protective mechanisms with probiotics having the greatest clinical range. Probiotics’ amelioration of atopic dermatitis and opportunistic infections of skin burns has been targeted in recent research efforts. This includes the improvement of Scoring Atopic Dermatitis index scores, p = 0.02, with intact Lactobacillus rhamnosus Goldin and Gorbach (LGG) in comparison to heat inactivated LGG or placebo. Lactobacillus reuteri used prior to or concurrently with Staphylococcus aureus infection can increase epidermal keratinocyte survival, p < 0.01. Phenolics may not have been extensively studied for atopic dermatitis or skin burns. However, phenolics do have a role in photoprotection. The phenolic rutin increases ultraviolet B radiation filter reactive oxygen species scavenging at 75%, p < 0.002, and peak wavelength absorption, p < 0.001. While oral and topical probiotics have untapped potential for atopic dermatitis amelioration and skin infection prevention, phenolics will be increasingly used for photoprotection. With optimized bioavailability, dosage, and formulation, nutraceuticals will become crucial for healthy skin maintenance.

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Prevention of polymorphic light eruption by oral administration of a nutritional supplement containing lycopene, β‐carotene, and Lactobacillus johnsonii: results from a randomized, placebo‐controlled, double‐blinded study

Abstract: The nutritional supplement provides protection against the development of UVA-induced PLE lesions at clinical and molecular levels.

Cited by 33 publications

References 12 publications

Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: results from a double-blinded, placebo-controlled, crossover study

Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: results from a double-blinded, placebo-controlled, crossover study

Antioxidants in dermatology

Skin Protective Nutraceuticals: The Current Evidence in Brief

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