Prevention of pertussis: Recommendations derived from the second Global Pertussis Initiative roundtable meeting

Forsyth, Kevin; König, Carl Heinz Wirsing von; Tan, Tina Q.; Jaime, J.; Plotkin, Stanley А.

doi:10.1016/j.vaccine.2006.12.017

Cited by 159 publications

(97 citation statements)

References 63 publications

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“…Recent immunization efforts have focused on adults, because the disease in this age group is often overlooked and unrecognized (225,251,282,523). Moreover, adolescents and adults are usually the primary source of B. pertussis transmission to neonates and infants, who are at risk of infection themselves (476,498,(524)(525)(526)(527). As a result, another acellular pertussis vaccine (Tdap) was developed for adolescent and adult use.…”

Section: Tdap Immunization For Adolescents and Adultsmentioning

confidence: 99%

Pertussis: Microbiology, Disease, Treatment, and Prevention

et al. 2016

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SUMMARYPertussis is a severe respiratory infection caused byBordetella pertussis, and in 2008, pertussis was associated with an estimated 16 million cases and 195,000 deaths globally. Sizeable outbreaks of pertussis have been reported over the past 5 years, and disease reemergence has been the focus of international attention to develop a deeper understanding of pathogen virulence and genetic evolution ofB. pertussisstrains. During the past 20 years, the scientific community has recognized pertussis among adults as well as infants and children. Increased recognition that older children and adolescents are at risk for disease and may transmitB. pertussisto younger siblings has underscored the need to better understand the role of innate, humoral, and cell-mediated immunity, including the role of waning immunity. Although recognition of adult pertussis has increased in tandem with a better understanding ofB. pertussispathogenesis, pertussis in neonates and adults can manifest with atypical clinical presentations. Such disease patterns make pertussis recognition difficult and lead to delays in treatment. Ongoing research using newer tools for molecular analysis holds promise for improved understanding of pertussis epidemiology, bacterial pathogenesis, bioinformatics, and immunology. Together, these advances provide a foundation for the development of new-generation diagnostics, therapeutics, and vaccines.

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Section: Tdap Immunization For Adolescents and Adultsmentioning

confidence: 99%

Pertussis: Microbiology, Disease, Treatment, and Prevention

et al. 2016

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“…However, to improve disease control and limit the risk of transmitting B. pertussis to susceptible infants, the immunization strategies may be further reinforced. There is an ongoing debate whether other age groups also should be vaccinated, e.g., adolescents and new parents (12).…”

mentioning

confidence: 99%

Immunization of Teenagers with a Fifth Dose of Reduced DTaP-IPV Induces High Levels of Pertussis Antibodies with a Significant Increase in Opsonophagocytic Activity

Aase¹,

Herstad²,

Merino³

et al. 2011

Clin. Vaccine Immunol.

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Waning vaccine-induced immunity against Bordetella pertussis is observed among adolescents and adults. A high incidence of pertussis has been reported in this population, which serves as a reservoir for B. pertussis. A fifth dose of reduced antigen of diphtheria-tetanus-acellular-pertussis and inactivated polio vaccine was given as a booster dose to healthy teenagers. The antibody activity against B. pertussis antigens was measured prior to and 4 to 8 weeks after the booster by different assays: enzyme-linked immunosorbent assays (ELISAs) of IgG and IgA against pertussis toxin (PT) and filamentous hemagglutinin (FHA), IgG against pertactin (PRN), opsonophagocytic activity (OPA), and IgG binding to live B. pertussis. There was a significant increase in the IgG activity against PT, FHA, and PRN following the booster immunization (P < 0.001). The prebooster sera showed a geometric mean OPA titer of 65.1 and IgG binding to live bacteria at a geometric mean concentration of 164.9 arbitrary units (AU)/ml. Following the fifth dose, the OPA increased to a titer of 360.4, and the IgG concentration against live bacteria increased to 833.4 AU/ml (P < 0.001 for both). The correlation analyses between the different assays suggest that antibodies against FHA and PRN contribute the most to the OPA and IgG binding.

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“…2 The epidemiology of pertussis shows a cyclic pattern, with epidemic peaks every 3-5 y. [3][4][5][6][7] Pertussis is highly transmissible in the catarrhal stage, resulting in frequent outbreaks that are difficult to detect and control. 8 Outbreaks typically occur in schools (high, middle or elementary) or other institutions when vaccine protection against pertussis begins to wane.…”

Section: Introductionmentioning

confidence: 99%