Prevention of peritoneal adhesions formation by core-shell electrospun ibuprofen-loaded PEG/silk fibrous membrane

Nadri, Samad; Rahmani, Ali; Hosseini, Seyed Nejat; Habibizadeh, Mina; Araghi, Mahmood; Mostafavi, Hossein

doi:10.1080/21691401.2021.1883043

Cited by 7 publications

(6 citation statements)

References 52 publications

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“…The results suggested that silk nanofiber cryogels had anti-inflammation effect, consistent with previous studies. [54][55][56][57] The various topographies of the silk nanofiber cryogels induced diverse polarization of macrophages. Compared to that in the SNFH-H cryogels, a higher ratio of M 2 / M 1 macrophages appeared in the SNFH-A cryogels with ani-sotropic structures (Figure 3d).…”

Section: In Vitro Cell Behavior In Cryogelsmentioning

confidence: 99%

Simulation of Cortical and Cancellous Bone to Accelerate Tissue Regeneration

Fan

Liu

Ding

et al. 2023

Adv Funct Materials

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Different tissues have complex anisotropic structures to support biological functions. Mimicking these complex structures in vitro remains a challenge in biomaterials designs. Here, inspired by different types of silk nanofibers, a composite materials strategy is pursued toward this challenge. A combination of fabrication methods is utilized to achieve separate control of amorphous and beta‐sheet rich silk nanofibers in the same solution. Aqueous solutions containing two types of silk nanofibers are simultaneously treated with an electric field and with ethylene glycol diglycidyl ether (EGDE). Under these conditions, the beta‐sheet rich silk nanofibers in the mixture responded to the electric field while the amorphous nanofibers are active in the crosslinking process with the EGDE. As a result, cryogels with anisotropic structures are prepared, including mimics for cortical‐ and cancellous‐like bone biomaterials as a complex osteoinductive niche. In vitro studies revealed that mechanical cues of the cryogels induced osteodifferentiation of stem cells while the anisotropy inside the cryogels influenced immune reactions of macrophages. These bioactive cryogels also stimulated improved bone regeneration in vivo through modulation of inflammation, angiogenesis and osteogenesis responses, suggesting an effective strategy to develop bioactive matrices with complex anisotropic structures beneficial to tissue regeneration.

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Section: In Vitro Cell Behavior In Cryogelsmentioning

confidence: 99%

Simulation of Cortical and Cancellous Bone to Accelerate Tissue Regeneration

Fan

Liu

Ding

et al. 2023

Adv Funct Materials

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“…Among them, immune factors and angiogenesis are important factors affecting the formation of an excellent healing microenvironment in the tendon repair process. After a tendon injury, it is vital to avoid the abnormal migration of fibroblasts, so the fibrous membrane should be made into a barrier structure with a small pore diameter [15,37,43,46] to prevent fibroblasts around the tendon from invading the healing end of the tendon. [20,23,47] In addition, abnormal macrophage activity is the main driving factor of many kinds of tissue fibrosis during the inflammatory period.…”

Section: Discussionmentioning

confidence: 99%

“…adhesion, resulting in severe disability, [1] which will not only seriously affect the motor function of the limbs but also increase the economic burden of individuals and society. [2] At present, the primary methods to prevent the formation of tendon adhesion are drug prevention, [3][4][5][6][7][8][9] material barrier, [10][11][12][13][14][15][16] clinical prevention, [17][18][19] and combination. [5,15,20] Among them, material barrier combined with drug prevention is the current leading research direction.…”

mentioning

confidence: 99%

“…[2] At present, the primary methods to prevent the formation of tendon adhesion are drug prevention, [3][4][5][6][7][8][9] material barrier, [10][11][12][13][14][15][16] clinical prevention, [17][18][19] and combination. [5,15,20] Among them, material barrier combined with drug prevention is the current leading research direction. The above methods usually inhibit inflammation by loading anti-inflammatory drugs or anti-inflammatory factors or separating exogenous cells from the surrounding tendon sheath to prevent adhesion.…”

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confidence: 99%

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Oriented Fibers Cooperate with DFO to Prevent Tendon Adhesions by Improving the Repair Microenvironment

Wang

Zhang

et al. 2023

Adv Materials Inter

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To solve the problem of tendon adhesion after an operation, an anti‐adhesion membrane is designed, which can inhibit the exogenous healing of tendons and promote endogenous healing. Here, poly[3(S)‐methyl‐morpholine‐2,5‐dione‐co‐lactic acid] P(MMD‐co‐LA) containing alanine units is obtained by melt ring‐opening polymerization (ROP). It can effectively reduce the production of acidic degradation products that cause aseptic inflammation. Then a kind of oriented P(MMD‐co‐LA)/deferoxamine (DFO) anti‐adhesion membrane with good mechanical properties, cell adhesion properties, and induced macrophage polarization properties is constructed by electrospinning. In vitro and in vivo studies have shown that oriented fibrous membranes can down‐regulate the expression of inflammatory cytokines. In addition, the fibrous membrane can up‐regulate the expression of angiogenesis‐related genes, namely HIF1‐α, SDF‐1α, and VEGF, by releasing DFO in situ, thus promoting the revascularization of tendon defects and providing nutritional support for endogenous tendon healing. This method provides a new barrier strategy to reduce tendon adhesion through anti‐inflammation combined with vascularization to inhibit exogenous tendon healing while promoting tendon endogenous healing. The results provide essential insights into the corresponding regulation of the tendon healing microenvironment.

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“…This was consistent with a previous study that reported a slight decrease in cell viability due to adding IBU fibers. 58 We further investigated whether IBU released from the Janus composite nanofiber membrane was anti-inflammatory active and whether the amount of the released IBU would be sufficient to mitigate the inflammatory response to LPS. As shown in Figure 7b, the untreated RAW 264.7 cells (neg.control) had a smooth circular shape.…”

Section: Cytotoxicity and In Vitro Anti-inflammatory Assaymentioning

confidence: 99%

Phase Change Material-Embedded Multifunctional Janus Nanofiber Dressing with Directional Moisture Transport, Controlled Release of Anti-Inflammatory Drugs, and Synergistic Antibacterial Properties

Liu,

Huang,

Liang

et al. 2023

ACS Appl. Mater. Interfaces

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Wound healing is a systematic and complex process that involves various intrinsic and extrinsic factors affecting different stages of wound repair. Therefore, multifunctional wound dressings that can modulate these factors to promote wound healing are in high demand. In this work, a multifunctional Janus electrospinning nanofiber dressing with antibacterial and anti-inflammatory properties, controlled release of drugs, and unidirectional water transport was prepared by depositing coaxial nanofibers on a hydrophilic poly(ε-caprolactone)@polydopamine-ε-polyl-lysine (PCL@PDA-ε-PL) nanofiber membrane. The coaxial nanofiber was loaded with the phase change material lauric acid (LA) in the shell layer and anti-inflammatory ibuprofen (IBU) in the core layer. Among them, LA with a melting point of 43 °C served as a phase change material to control the release of IBU. The phase transition of LA was induced by near-infrared (NIR) irradiation that triggered the photothermal properties of PDA. Moreover, the Janus nanofiber dressing exhibited synergistic antimicrobial properties for Escherichia coli and Staphylococcus aureus due to the photothermal properties of PDA and antibacterial ε-PL. The prepared Janus nanofiber dressing also exhibited anti-inflammatory activity and biocompatibility. In addition, the Janus nanofiber dressing had asymmetric wettability that enabled directional water transport, thereby draining excessive wound exudate. The water vapor transmission test indicated that the Janus nanofiber dressing had good air permeability. Finally, skin wound healing evaluation in rats confirmed its efficacy in promoting wound healing. Therefore, this strategy of designing and manufacturing a multifunctional Janus nanofiber dressing had great potential in wound healing applications.

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Prevention of peritoneal adhesions formation by core-shell electrospun ibuprofen-loaded PEG/silk fibrous membrane

Cited by 7 publications

References 52 publications

Simulation of Cortical and Cancellous Bone to Accelerate Tissue Regeneration

Simulation of Cortical and Cancellous Bone to Accelerate Tissue Regeneration

Oriented Fibers Cooperate with DFO to Prevent Tendon Adhesions by Improving the Repair Microenvironment

Phase Change Material-Embedded Multifunctional Janus Nanofiber Dressing with Directional Moisture Transport, Controlled Release of Anti-Inflammatory Drugs, and Synergistic Antibacterial Properties

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