Prevention of peri-implant skin inflammation using an acrylic resin housing with a tunnel design for an implant-retained auricular prosthesis

Phan, Hai; Chotprasert, Natdhanai; Shakya, Prana; Srithavaj, M.L. Theerathavaj

doi:10.1016/j.prosdent.2016.10.012

Cited by 1 publication

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“…[ 4 8 ] Expanding forces caused by the vegetative yeasts penetrating through the porosity resulted in softening of the edge, margin degradation, and permanent black discoloration of the silicones, and some needed to be replaced with a more comprehensive design. [ 2 3 , 9 10 ] The fungal infection may possibly cause a non-life-threatening mucocutaneous candidiasis or a life-threatening candidemia ( Candida bloodstream infection) through the dissemination of single or clustered cells from the fungal biofilm in conjunction with its inherent drug-resistance capacity. [ 5 11 ] The Candida infection affects directly on people with immunocompromised conditions, including patients with cancer who have undergone a chemotherapy and/or radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

Fungicidal Effect of Lemongrass Essential Oil on Candida albicans Biofilm Pre-established on Maxillofacial Silicone Specimens

Mat-Rani

Chotprasert

Srimaneekarn

et al. 2021

Journal of International Society of Preventive and Community Dentistry

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A BSTRACT Aims: This in-vitro study aimed to evaluate the efficacy of lemongrass ( Cymbopogon citratus ) essential oil in eradicating Candida albicans biofilm pre-established on the maxillofacial silicone specimens. Materials and Methods: Two maxillofacial silicones, namely, MDX4-4210 and Multisil Epithetik, were used for the fabrication of 6 mm diameter disks ( n = 21 for each brand of silicone). A 48-h mature C. albicans ATCC 10231 biofilm was pre-established on sterile silicone specimen. These disks were then exposed to various concentrations of lemongrass essential oil ranging from 0.31% to 5% (v/v), 20% (v/v) nystatin, and RPMI-1640 medium for 18–20 h. After exposure, the remaining viable fungal biofilm was examined by the XTT [2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide]-reduction assay. All data were analyzed by using a regression coefficient and a post hoc Tukey HSD multiple comparisons test ( α = 0.05). Results: Different brands of silicone used for fabrication did not significantly affect the formation of mature C. albicans biofilm ( P =0.302). A 5% (v/v) lemongrass essential oil significantly eliminated fungal biofilm by approximately 95% ( P =0.031). However, less than 50% of the fungal biofilm was eliminated by the tested oil at a concentration as low as 0.31% (v/v). Furthermore, the fungicidal efficacy against C. albicans biofilm of lemongrass essential oil at 2.5% (v/v) was as potent as that of 20% (v/v) nystatin suspension ( P = 0.99). Conclusion: Lemongrass essential oil expressed fungicidal effect on C. albicans biofilm pre-established on the disks fabricated from different brands of silicone. Additionally, the fungicidal effectiveness of the oil against the mature fungal biofilm was dose-dependent.

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