Prevention of NTDs with periconceptional multivitamin supplementation containing folic acid in China

Chen, Gong; Song, Xiaomin; Ji, Ying; Zhang, Lei; Pei, Lijun; Chen, Jiapeng; Liu, Jufen; Li, Cheng-Fu; Zheng, Xiaoying

doi:10.1002/bdra.20471

Cited by 30 publications

(34 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Doses ranging from 360 μg (0.36 mg) (Kirke 1992) to 6000 μg (6 mg) (Chen 2008) a day have proven to be effective in preventing both occurrence and recurrence of NTDs; this wide response to supplementation may be determined by the baseline blood folate concentrations in each population. Improving nutrition surveillance in order to find the appropriate dose and supplementation scheme is crucial to promote a cost-effective public health policy that can reach a larger number of people.…”

Section: Summary Of Main Resultsmentioning

confidence: 99%

Effects and safety of periconceptional folate supplementation for preventing birth defects

Regil

Fernández-Gaxiola

Dowswell

et al. 2009

Cochrane Database of Systematic Reviews

164

182

View full text Add to dashboard Cite

Section: Summary Of Main Resultsmentioning

confidence: 99%

Effects and safety of periconceptional folate supplementation for preventing birth defects

Regil

Fernández-Gaxiola

Dowswell

et al. 2009

Cochrane Database of Systematic Reviews

164

182

View full text Add to dashboard Cite

“…If basic nutritional deficiency is the disease cause, nutritional supplements can reduce prevalence. Actually, nutrition intervention had been conducted in some Heshun province and the effects are remarkable (Chen et al 2008). The genetic factor is not concluded in environmental models but is left in model residuals.…”

Section: Conclusion and Discussionmentioning

confidence: 99%

Geographical Detectors‐Based Health Risk Assessment and its Application in the Neural Tube Defects Study of the Heshun Region, China

Wang

Christakos

et al. 2010

International Journal of Geographical Information Science

1,807

902

View full text Add to dashboard Cite

Physical environment, man-made pollution, nutrition and their mutual interactions can be major causes of human diseases. These disease determinants have distinct spatial distributions across geographical units, so that their adequate study involves the investigation of the associated geographical strata. We propose four geographical detectors based on spatial variation analysis of the geographical strata to assess the environmental risks of health: the risk detector indicates where the risk areas are; the factor detector identifies factors that are responsible for the risk; the ecological detector discloses relative importance between the factors; and the interaction detector reveals whether the risk factors interact or lead to disease independently. In a real-world study, the primary physical environment (watershed, lithozone and soil) was found to strongly control the neural tube defects (NTD) occurrences in the Heshun region (China). Basic nutrition (food) was found to be more important than man-made pollution (chemical fertilizer) in the control of the spatial NTD pattern. Ancient materials released from geological faults and subsequently spread along slopes dramatically increase the NTD risk. These findings constitute valuable input to disease intervention strategies in the region of interest.

show abstract

“…Recent studies showed that prenatal multimicronutrient supplementation was associated with a significantly reduced risk of low birth weight when compared with iron-folic acid supplementation [62, 63]. Moreover, Chen et al proved that periconceptional multivitamin supplementation containing folic acid—two months before conception and until completion of the second month—containing folic acid can prevent the occurrence of NTDs [64]. These maternal and paternal nutritional deficiencies are probably multicausal.…”

Section: Characteristics Of Folate Deficiencymentioning

confidence: 99%

Periconceptional Folate Deficiency and Implications in Neural Tube Defects

Safi

Joyeux

Chalouhi

2012

Journal of Pregnancy

View full text Add to dashboard Cite

Nutritional deficiencies are preventable etiological and epigenetic factors causing congenital abnormalities, first cause of infant mortality. Folate deficiency has a well-established teratogenic effect, leading to an increasing risk of neural tube defects. This paper highlights the most recent medical literature about folate deficiency, be it maternal or paternal. It then focuses on associated deficiencies as nutritional deficiencies are multiple and interrelated. Observational and interventional studies have all been consistent with a 50–70% protective effect of adequate women consumption of folates on neural tube defects. Since strategies to modify women's dietary habits and vitamin use have achieved little progress, scientific as well as political effort is mandatory in order to implement global preventive public health strategies aimed at improving the alimentation of women in reproductive age, especially folic acid supplementation. Even with the recent breakthrough of fetal surgery for myelomeningocele, the emphasis should still be on prevention as the best practice rather than treatment of neural tube defects.

show abstract

Prevention of NTDs with periconceptional multivitamin supplementation containing folic acid in China

Cited by 30 publications

References 25 publications

Effects and safety of periconceptional folate supplementation for preventing birth defects

Effects and safety of periconceptional folate supplementation for preventing birth defects

Geographical Detectors‐Based Health Risk Assessment and its Application in the Neural Tube Defects Study of the Heshun Region, China

Periconceptional Folate Deficiency and Implications in Neural Tube Defects

Contact Info

Product

Resources

About