Prevention of morphine dependence and tolerance by Nepeta menthoides was accompanied by attenuation of Nitric oxide overproduction in male mice

Rahmati, Batool; Beik, Ahmad

doi:10.1016/j.jep.2017.01.032

Cited by 16 publications

(14 citation statements)

References 60 publications

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“…In this scenario, NO synthesized upon NMDA receptor stimulation [46], seems to play an important role not only in learning and memory processes [47] and HP LTP [48], but also contribute to the neuronal adaptations induced by different addictive [24][25][26]49]. Indeed, likewise to the MK-801 effects, inhibition of NO synthesis reduces withdrawal expression from psychostimulants [28], nicotine [29], opioids [30,31,50], ethanol [32] and BZD [27]. Furthermore, chronic nicotine withdrawal increases NOS-1 immunoreactivity in the Dorsal Raphe Nueclues and Locus Coeruleus of adult rats [51].…”

Section: Discussionmentioning

confidence: 99%

Diazepam Withdrawal Expression is related to Hippocampal NOS-1 Upregulation

Pérez¹

2017

Arch Pharm Pharm Sci

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Background: Benzodiazepines are usually prescribed for anxiety and sleep disorders in a long-term fashion that may cause drug dependence. Discontinuation after prolonged administration may lead to withdrawal expression, being anxiety the most predominant sign. It has been described that a contextdependent associative learning process underlies diazepam dependence. Nitric oxide is a crucial player in learning and memory processes, hippocampal transmission, as well as in benzodiazepines withdrawal. Considering that previous results from our laboratory showed an increase in hippocampal functional plasticity only in diazepam dependent rats, the aim of the present investigation is to determine whether diazepam dependence could alter neuronal nitric oxide synthase enzyme (NOS-1) expression within the hippocampus, by using western blot. Results: chronic diazepam-treated animals that developed dependence showed increase in NOS-1 expression in dorsal, but not in ventral hippocampus, while no-dependent or control animals presented similar NOS-1 protein levels. Conclusion: withdrawal from long-term diazepam exposure could be associated to increased nitric oxide neurotransmission within dorsal hippocampus induced by NOS-1 over-expression. This mechanism could underlie the improved hippocampal synaptic transmission previously observed in diazepam withdrawn animals. Confi rmatory experiments need to be addressed to determine the mechanisms by which nitric oxide participates in benzodiazepines withdrawal in order fi nd new molecular targets to develop pharmacological tools to prevent the withdrawal syndrome.

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Section: Discussionmentioning

confidence: 99%

Diazepam Withdrawal Expression is related to Hippocampal NOS-1 Upregulation

Pérez¹

2017

Arch Pharm Pharm Sci

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“…Furthermore, N. menthoides prevented the acquisition of morphine tolerance and potentiated morphine analgesic effect in a synergistic manner. It appears that inhibition of the nitric oxide (NO) overproduction is the main mechanism responsible for these effects of N. menthoides (40).…”

Section: Cytotoxic Activitymentioning

confidence: 99%

Nepeta menthoides Boiss. & Buhse, an endemic species in Iran: A review of traditional uses, phytochemistry and pharmacology

Memariani

Rahimi

Farzaei

et al. 2019

J Herbmed Pharmacol

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Implication for health policy/practice/research/medical education:As one of the endemic species in Iran, Nepeta menthoides is widely used as medicinal plant by the vernacular name "Ostokhodus" in traditional Persian medicine. Reviewing the scientific evidence via collecting, classifying and summarizing published studies on the medicinal properties and possible side effects of this plant can be helpful for therapists and researchers in traditional medicine. It also provides basic information for further research as a coherent herbal monograph.Please cite this paper as: Memariani Z, Rahimi A, Farzaei MH, Zakaria Nejad N. Nepeta menthoides Boiss. & Buhse, an endemic species in Iran: A review of traditional uses, phytochemistry and pharmacology.

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“…On the other hand, linalool, another main compound of this plant, inhibited N ‐methyl‐ d ‐aspartate receptors (Hosseinzadeh, Imenshahidi, Hosseini, & Razavi, ). Thus, N. menthoides may be a promising candidate plant against morphine addiction (Rahmati & Beik, ).…”

Section: Biological Activity Studies On Nepeta L Genusmentioning

confidence: 99%

“…Anticonvulsant and myorelaxant activity researches on N. sibthorpii, N. cataria, and N. ruderalis have shown that these three species possess anticonvulsant and myorelaxant effects (Galati et al, 2004;Gilani et al, 2009;Mahmood et al, 2017). N. menthoides attenuated the development of morphine dependence and potentiated morphine analgesia (Rahmati & Beik, 2017). N. cataria enhanced penile erection and improved the sexual behavior of male rats (Bernardi et al, 2011).…”

Section: Effects On Sexual Behaviormentioning

confidence: 99%

Pharmacological and chemical features of Nepeta L. genus: Its importance as a therapeutic agent

Süntar

Nabavi

Barreca

et al. 2017

Phytotherapy Research

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Medicinal plants have always had great value for the human population due to their valuable constituents and potential bioactivities. The objective of this review is to present an updated overview of an important medicinal plant genus Nepeta L., from the family Lamiaceae, revealing its traditional utilization, biological activity, phytoconstituents, and mechanisms of action. For this purpose, a literature survey was carried out by using SciFinder, ScienceDirect, Scopus, PubMed, and Web of Science followed by a revision of the bibliographies of the related articles. We have described and analyzed the role of plants in drug discovery and the importance of Nepeta species. Information on the utilization purposes of Nepeta species in folk medicine has been emphasized, and scientific studies on the biological effects and secondary metabolites are addressed. Nepeta species are characterized by terpenoid-type compounds and phenolic constituents, which exert several activities such as an antimicrobial, repellent against major pathogen vector mosquitoes, insecticide, larvicide against Anopheles stephensi, cytotoxic anticarcinogen, antioxidant, anticonvulsant, analgesic, anti-inflammatory agent, and antidepressant, revealing its importance in medicinal and agricultural fields. On the basis of numerous studies, the Nepeta genus demonstrates remarkable therapeutic effects against various diseases. However, clinical studies are warranted to confirm preclinical findings.

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Prevention of morphine dependence and tolerance by Nepeta menthoides was accompanied by attenuation of Nitric oxide overproduction in male mice

Cited by 16 publications

References 60 publications

Diazepam Withdrawal Expression is related to Hippocampal NOS-1 Upregulation

Diazepam Withdrawal Expression is related to Hippocampal NOS-1 Upregulation

Nepeta menthoides Boiss. & Buhse, an endemic species in Iran: A review of traditional uses, phytochemistry and pharmacology

Pharmacological and chemical features of Nepeta L. genus: Its importance as a therapeutic agent

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