Prevention of Malignant Transformation of Oral Leukoplakia and Oral Lichen Planus Using Laser: An Observational Study

Arora, Karandeep Singh; Bansal, Rahul; Mohapatra, Shreeyam; Verma, Akshay; Sharma, Sakshi; Pareek, Shubhangi

doi:10.31557/apjcp.2018.19.12.3635

Cited by 12 publications

(3 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most of the studies demonstrated the beneficial effect of LLLT in accelerating the healing process and pain reduction. 22 In the year 2018, Karandeep S A et al 23 conducted an observational study with an aim to evaluate the efficacy of diode laser in the management of homogenous oral leukoplakia (OL) and reticular oral lichen planus (OLP). None of the subjects reported of pain, swelling, or bleeding and it was noted that all the areas treated with laser had healed without scarring with no signs of recurrence.…”

Section: Discussionmentioning

confidence: 99%

Use of laser in the management of leukoplakia and oral lichen planus - A systematic review

Zafar

Makkar

2023

JDP

View full text Add to dashboard Cite

This article is a systematic review to evaluate the role of LASER in the treatment of LP and OLP. These two are potentially malignant disorder with a high prevalence rate and malignant transformation. Many treatment modality is been stated for the same but LASER has attracted special attention for properties it possess.: The aim of this research was to compare the effectiveness of LASER (light amplification by stimulated emission of radiation) on the management of leukoplakia and lichen planus. Electronic databases (PubMed, Scopus) were searched, using various combinations of the following keywords: potentially malignant disorders, leukoplakia, oral lichen planus, and LASER therapy from the year 2002 to 2021. Owing to the heterogeneity of data, no statistical analyses were conducted. This systematic review shows that ablation for LP and LLLT for OLP plays a significant therapeutic role in decreasing reoccurrence and malignant transformation. LASER is an effective mode for treatment of LP and OLP.

show abstract

Section: Discussionmentioning

confidence: 99%

Use of laser in the management of leukoplakia and oral lichen planus - A systematic review

Zafar

Makkar

2023

JDP

View full text Add to dashboard Cite

show abstract

“…Katayama et al (50) applied immunohistochemistry to detect the expression of MMPs and TIMPs in 53 early oral cancer biopsy specimens and reported that the high expression of TIMP-2 was an independent factor for the poor prognosis of early OSCC. Furthermore, Arora et al (51) assessed the expression of type IV collagen in OL and reported that the inhibition of collagen decomposition delayed OL deterioration and tumor spread. The aforementioned evidence suggested that these functions and pathways have specific roles in the progression from OL to OSCC.…”

Section: Fdrsmentioning

confidence: 99%

Analysis of transcriptome expression profiling data in oral leukoplakia and early and late‑stage oral squamous cell carcinoma

Yao

Guo²,

Wang

et al. 2023

Oncol Lett

View full text Add to dashboard Cite

The present study screened, potential prognostic biomarkers for oral carcinogenesis. The GSE85195 dataset, which consisted of oral leukoplakia (OL) and early and late-stage oral squamous cell carcinoma (OSCC) samples, was used. The differentially expressed genes (DEGs) in early OSCC vs. OL, late OSCC vs. OL and late OSCC vs. early OSCC groups were screened using the limma package in R. The Short Time-series Expression Miner software package was used to cluster DEGs with similar expression patterns in the course of disease progression (from OL to early and then late-stage OSCC). Moreover, the Database for Annotation, Visualization and Integrated Discovery online analysis tool was used to perform Gene Ontology functional annotation and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. A protein-protein interaction (PPI) network was also constructed using the Search Tool for the Retrieval of Interacting Genes/Proteins database. Reverse transcription-quantitative PCR was performed to assess the mRNA expression levels of hub node genes in clinical samples, and receiver operating characteristic curve analysis was performed to assess the prognostic value of the hub genes. A total of 4,595, 6,042 and 2,738 DEGs were screened in the early OSCC vs. OL, late OSCC vs. OL and late OSCC vs. early OSCC groups, respectively. A total of 665 overlapping genes were identified when the screened DEGs were compared. Cluster 1 and cluster 7 were identified as the significant clusters, which contained 496 and 341 DEGs, respectively. A PPI network was constructed with 440 interaction pairs. There were five differentially expressed hub nodes identified in different stages from OL to OSCC. The results of the present study indicated that fibronectin 1, signal transducer and activator of transcription 1, collagen type II α1 chain, collagen type X α1 chain and collagen type IV α6 chain might serve as independent diagnostic factors for OL and OSCC, and as prognostic biomarkers for OL carcinogenesis.

show abstract

“…Diode laser (810 nm) has been used to treat oral leukoplakia and oral lichen planus. [ 1 ] CO2 laser has been used in conditions like aphthous ulcers and tissue excesses. [ 2 ] Working with a laser requires safety precautions to avoid accidental exposure.…”

mentioning

confidence: 99%

Detection of retinal laser injury using confocal scanning laser imaging

Roy¹,

Saurabh

Biswas³

et al. 2020

Indian J Ophthalmol

View full text Add to dashboard Cite

The use of laser energy in medical practice requires specific safety measures. Accidental ocular exposure of laser can have vision-threatening consequences. We report a case of accidental laser exposure in a dentist who was working with a diode laser. The patient presented within 24 hours of exposure and the clinical fundus examination and spectral-domain optical coherence tomography (SDOCT) were unremarkable at this time. Blue light autofluorescence (BAF) and multicolor images obtained using the Spectralis SDOCT system revealed the laser impact site. The multicolor image showed a larger extent of retinal involvement highlighting its role in imaging.

show abstract

Prevention of Malignant Transformation of Oral Leukoplakia and Oral Lichen Planus Using Laser: An Observational Study

Cited by 12 publications

References 29 publications

Use of laser in the management of leukoplakia and oral lichen planus - A systematic review

Use of laser in the management of leukoplakia and oral lichen planus - A systematic review

Analysis of transcriptome expression profiling data in oral leukoplakia and early and late‑stage oral squamous cell carcinoma

Detection of retinal laser injury using confocal scanning laser imaging

Contact Info

Product

Resources

About