Prevention of malignant digestive system tumors should focus on the control of chronic inflammation

Abstract

Chronic inflammation, through a variety of mechanisms, plays a key role in the occurrence and development of digestive system malignant tumors (DSMTs). In this study, we feature and provide a comprehensive understanding of DSMT prevention strategies based on preventing or controlling chronic inflammation. The development and evaluation of cancer prevention strategies is a longstanding process. Cancer prevention, especially in the early stage of life, should be emphasized throughout the whole life course. Issues such as the time interval for colon cancer screening, the development of direct-acting antiviral drugs for liver cancer, and the Helicobacter pylori vaccine all need to be explored in long-term, large-scale experiments in the future.

Intratumoral Microbiota: Unraveling their Oncogenic Impact on Cancer Progression With Focus on Breast Cancer Therapeutic Outcomes

“…Helicobacter pylori express a cytotoxin-associated gene A (CagA) protein which, upon binding to the host cell, leads to aberrant activation of β-catenin, and in turn, leads to transcriptional activation of carcinogenic genes and, ultimately, gastric cancer (47). Chronic infection by Salmonella typhimurium has been associated with an increased risk of hepatobiliary cancer and colorectal cancer (48,49). AvrA secreted by S. typhimurium can activate βcatenin and STAT-3 signaling, leading to chronic inflammation and cancer formation (49,50).…”