Prevention of malaria in pregnancy

Desai, Meghna; Hill, Jenny; Fernandes, Silke; Walker, Patrick; Pell, Christopher; Gutman, Julie; Kayentao, Kassoum; González, Raquel; Webster, Jayne; Greenwood, Brian; Cot, Michel; Kuile, Feiko O. ter

doi:10.1016/s1473-3099(18)30064-1

Cited by 116 publications

(98 citation statements)

References 114 publications

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“…Two published trials compared IST using DP (IST‐DP) with IPT‐SP . An overview of interventions for the prevention of malaria in pregnancy reported three published trials of ACTs involving DP as either IPT or IST, and suggested DP as a potential alternative to IPT‐SP …”

Section: Discussionmentioning

confidence: 99%

“…Intermittent preventive treatment with SP is currently used 12,19 An overview of interventions for the prevention of malaria in pregnancy reported three published trials of ACTs involving DP as either IPT or IST, and suggested DP as a potential alternative to IPT-SP. 24 The three studies included in this review involved a total of 3719 participants. Two of the trials were conducted in East Africa, and one in Southern Africa.…”

Section: Discussionmentioning

confidence: 99%

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A systematic review and meta‐analysis of dihydroartemisinin‐piperaquine versus sulphadoxine‐pyrimethamine for malaria prevention in pregnancy

Olaleye

Okusanya

Oduwole

et al. 2019

Intl J Gynecology & Obste

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Background Intermittent preventive treatment (IPT) with sulphadoxine‐pyrimethamine (SP) is recommended for preventing maternal and fetal effects of malaria in pregnancy. Increasing parasite resistance to SP has necessitated the search for an alternative medication. Objective To compare dihydroartemisinin‐piperaquine (DP) and sulphadoxine‐pyrimethamine in preventing malaria during pregnancy. Search strategy Databases including CENTRAL, MEDLINE, and ICTRP were searched until August 2018. Selection criteria Randomized and quasi‐randomized controlled trials that compared DP with SP given to pregnant women to prevent adverse maternal or fetal effects of malaria were included. Data collection and analysis Quality of evidence was determined with GRADE criteria. Effectiveness measures were calculated using odds ratios at 95% confidence intervals. Results Three randomized controlled trials were included. Compared with IPT‐SP, moderate certainty evidence indicated that women who received IPT‐DP had significantly lower risks of clinical malaria during pregnancy. High certainty evidence showed intermittent screening and treatment with DP did not reduce placental malaria or maternal parasitemia at delivery. Effect of DP on low birth weight and adverse birth outcomes was minimal. Conclusions Moderate certainty evidence suggests that IPT‐DP may reduce maternal and placental malaria compared with IPT‐SP, and monthly DP is more effective than SP in reducing placental malaria. PROSPERO ID: CRD42018084651.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A systematic review and meta‐analysis of dihydroartemisinin‐piperaquine versus sulphadoxine‐pyrimethamine for malaria prevention in pregnancy

Olaleye

Okusanya

Oduwole

et al. 2019

Intl J Gynecology & Obste

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“…Plasmodium ‐derived components that activate innate immune mechanisms have been reviewed in detail elsewhere . Pregnant women are at an increased of placental P. falciparum infections, the scope of which can be found reviewed elsewhere . Relevant to this review is the consideration of localized immune modifications during antenatal infections that could impact an infant's ability to mount a protective immune response to malaria .…”

Section: Overview Of Malariamentioning

confidence: 99%

Immune effector mechanisms in malaria: An update focusing on human immunity

Moormann

Nixon

Forconi

2019

Parasite Immunology

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The past decade has witnessed dramatic decreases in malaria‐associated mortality and morbidity around the world. This progress has largely been due to intensified malaria control measures, implementation of rapid diagnostics and establishing a network to anticipate and mitigate antimalarial drug resistance. However, the ultimate tool for malaria prevention is the development and implementation of an effective vaccine. To date, malaria vaccine efforts have focused on determining which of the thousands of antigens expressed by Plasmodium falciparum are instrumental targets of protective immunity. The antigenic variation and antigenic polymorphisms arising in parasite genes under immune selection present a daunting challenge for target antigen selection and prioritization, and is a given caveat when interpreting immune recall responses or results from monovalent vaccine trials. Other immune evasion strategies executed by the parasite highlight the myriad of ways in which it can become a recurrent infection. This review provides an update on immune effector mechanisms in malaria and focuses on our improved ability to interrogate the complexity of human immune system, accelerated by recent methodological advances. Appreciating how the human immune landscape influences the effectiveness and longevity of antimalarial immunity will help explain which conditions are necessary for immune effector mechanisms to prevail.

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“…Un estudio de Cochrane demostró la eficacia de este fármaco en comparación con placebo o pacientes sin tratamiento (5,6). Existen otras opciones disponibles para prevención, sin embargo, la tolerancia no fue adecuada para recomendarlo como tratamiento, entre ellas sulfadoxina-pirimetamina y azitromicina, cloroquina-azitromicina y mefloquina(5).…”

Section: Quimioprofilaxisunclassified

Reporte de caso: infección grave por Plasmodium falciparum en viajera gestante que regresa de Ghana, África.

Carcode¹,

Mejía

Solera

2018

RC_UCR-HSJD

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La malaria es una enfermedad infecciosa causada por el protozoario Plasmodium spp. Inoculado al hospedero humano por el mosquito hembra Anopheles durante su alimentación; corresponde a una infección endémica en regiones tropicales.La infección grave por malaria suele asociarse principalmente al Plasmodium falciparum. Se presenta el caso de una paciente femenina en primer trimestre de embarazo, quien regresa de un viaje de Ghana, África; con síntomas de sangrado vaginal, fiebre y malestar general, por lo que es admitida al hospital para complementar estudios. Se hizo el diagnóstico de infección grave por P. falciparum y se inició manejo intravenoso con antipalúdicos.

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Prevention of malaria in pregnancy

Cited by 116 publications

References 114 publications

A systematic review and meta‐analysis of dihydroartemisinin‐piperaquine versus sulphadoxine‐pyrimethamine for malaria prevention in pregnancy

A systematic review and meta‐analysis of dihydroartemisinin‐piperaquine versus sulphadoxine‐pyrimethamine for malaria prevention in pregnancy

Immune effector mechanisms in malaria: An update focusing on human immunity

Reporte de caso: infección grave por Plasmodium falciparum en viajera gestante que regresa de Ghana, África.

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