Prevention of Left Ventricular Thrombus Formation and Systemic Embolism After Anterior Myocardial Infarction: A Systematic Literature Review

Bastiany, Alexandra; Grenier, Marie-Ève; Matteau, Alexis; Mansour, Samer; Daneault, Benoit; Potter, Brian J.

doi:10.1016/j.cjca.2017.07.479

Cited by 20 publications

(14 citation statements)

References 48 publications

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“…In light of the review by Bastiany et al, 1 and given that expert guidelines provide conflicting guidance for prevention of LVT (Canadian guidelines under preparation), 4 we agree with the authors that large-scale studies are required to improve patient care when addressing this commonly encountered clinical conundrum. Recent evidence showing an improved safety profile of various combinations of direct oral anticoagulants over warfarin in patients with percutaneous coronary intervention and atrial fibrillation could constitute the basis of a rationale for a trial focusing on patients with anterior STEMI and LV dysfunction.…”

Section: To the Editorsupporting

confidence: 56%

“…We would like to expand on the article by Bastiany et al, 1 recently published in the Canadian Journal of Cardiology, reviewing the heterogeneous literature focusing on the optimal long-term antithrombotic treatment for prevention of left ventricular thrombus (LVT) after anterior ST-elevation myocardial infarction (STEMI). They should be commended for undertaking this large amount of work, highlighting the fact that the contemporary incidence of LVT in these patients is ill-defined and that the antithrombotic regimen optimizing a trade-off between ischemic protection and bleeding risks is still lingering.…”

Section: To the Editormentioning

confidence: 99%

See 1 more Smart Citation

The Ongoing Quest for Optimal Thrombus Prevention After ST-Elevation Myocardial Infarction in the Modern Era

Marquis‐Gravel¹,

Ghersi²,

Boivin‐Proulx³

et al. 2018

Canadian Journal of Cardiology

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Section: To the Editorsupporting

confidence: 56%

Section: To the Editormentioning

confidence: 99%

The Ongoing Quest for Optimal Thrombus Prevention After ST-Elevation Myocardial Infarction in the Modern Era

Marquis‐Gravel¹,

Ghersi²,

Boivin‐Proulx³

et al. 2018

Canadian Journal of Cardiology

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“…According to the 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction, anterior wall myocardial infarction (AWMI) is a risk assessment index of Major Adverse Cardiovascular Events (MACE) (O'Gara et al, 2013). MI most likely occurs in the domain of the left anterior descending artery (LAD) (Park et al, 2014;Postma et al, 2015;Stone et al, 2016), which supplies nearly two-thirds of the whole heart blood (Bastiany et al, 2017). Infarct size is the percentage of infarcted myocardial mass to LV total mass.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Left Ventricular Global Strain in Anterior and Non-anterior Wall Myocardial Infarction With CMR Tissue Tracking

Zhao

et al. 2020

Front. Physiol.

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Left ventricular (LV) myocardial dysfunction occurs after myocardial infarction (MI) is associated with the location, infarct size, and transmurality degrees of MI. The myocardial strain is a sensitive index used for the quantification of myocardium dysfunction. This study used Tissue-Tracking to evaluate whether the different location of MI would result in different myocardial dysfunction. One hundred patients diagnosed with MI who underwent cardiovascular magnetic resonance examination were included. The tissue-tracking indices, LV global radial strain (GRS), global circumferential strain (GCS), global longitudinal strain (GLS), and the infarct size (IS,% of LV mass) were quantified. There were 42 cases of anterior wall MI (AWMI) and 58 cases of non-anterior wall MI (NAWMI). The GCS of AWMI was significantly lower than that of NAWMI (P = 0.036). In the same level of infarct size, the myocardial strain of AWMI was not significantly different from NAWMI group (P > 0.05). The GRS and GCS were significantly different between transmurality > 50% group with transmurality ≤ 50% group (P < 0.05). The present study demonstrated that LV MI is associated with reduced myocardial strain, and the infarct size and degrees of transmurality were both related to the decline of myocardial strain in patients with MI.

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“…Более того, из-за доступности новых, более мощных ингибиторов P2Y12, выбор традиционной тройной антитромботической терапии (ацетилсаллициловая кислота, клопидогрел и варфарин) означает повышение риска кровотечений и потенциальное исключение продемонстрированных в других исследованиях преиму-ществ двойной антитромботической терапии с применением тикагрелора или прасугрела. Высказывается предположение, что комбинация ацетилсалициловой кислоты с тикагрелором или прасугрелом может быть достаточной для профилактики тромбоза полости ЛЖ и снижения риска системной эмболии на его фоне [89].…”

Section: профилактика ишемического инсульта после инфаркта миокардаunclassified

Myocardial Infarction Complicated by Ischemic Stroke: Risk Factors, Prognosis, Unresolved Problems and Possible Methods of Prevention

Зыков¹,

Буцев²,

Suleymanov³

2021

Racionalʹnaâ farmakoterapiâ v kardiologii

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The present work is devoted to the analysis of modern publications on various aspects of the development and course of ischemic stroke in the presence of acute myocardial infarction. A literature search was conducted on the websites of cardiological and neurological societies, as well as on the PubMed, EMBASE, eLibrary databases using the keywords: myocardial infarction, acute coronary syndrome, stroke, acute cerebrovascular accident, myocardial infarction, acute coronary syndrome, stroke. The authors of this review found that although stroke is a relatively rare complication of myocardial infarction, its prevention is an extremely significant task, since it is associated with high mortality, disability and a significant increase in the cost of treatment. So, it is extremely important to detect thrombosis of the left ventricular cavity in a timely manner, to register preexisting atrial fibrillation that occurs earlier or for the first time, followed by the appointment of anticoagulant therapy. Timely reperfusion treatment, the use of statins and modern dual antithrombotic therapy can reduce the risk of developing cerebrovascular accident in patients with myocardial infarction. It is likely that a decrease in the activity of subclinical inflammation after myocardial infarction will also reduce the risk of stroke, as was recently shown in the COLCOT study. Currently, it remains relevant to search for new knowledge about the risk factors for stroke, which complicated the course of myocardial infarction, which will allow developing more effective and personalized preventive measures in a patient with acute coronary syndrome.

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Prevention of Left Ventricular Thrombus Formation and Systemic Embolism After Anterior Myocardial Infarction: A Systematic Literature Review

Cited by 20 publications

References 48 publications

The Ongoing Quest for Optimal Thrombus Prevention After ST-Elevation Myocardial Infarction in the Modern Era

The Ongoing Quest for Optimal Thrombus Prevention After ST-Elevation Myocardial Infarction in the Modern Era

Comparison of Left Ventricular Global Strain in Anterior and Non-anterior Wall Myocardial Infarction With CMR Tissue Tracking

Myocardial Infarction Complicated by Ischemic Stroke: Risk Factors, Prognosis, Unresolved Problems and Possible Methods of Prevention

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