Prevention of Late PJI

doi:10.1002/jor.22561

Cited by 4 publications

(1 citation statement)

References 211 publications

(204 reference statements)

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“…While early PJIs are often caused by perioperatively-seeded bacteria, late-onset PJIs are commonly attributed to hematogenous seeding [ 1 , [5] , [6] , [7] ]. Dental procedures create transient bacteremia, which can lead to hematogenous bacterial seeding and PJIs in TKA recipients [ [8] , [9] , [10] , [11] ]. To reduce the prevalence of PJIs, both the American Academy of Orthopaedic Surgeons (AAOS) and American Dental Association (ADA) previously recommended that all TKA recipients use antibiotic prophylaxis prior to dental procedures for two years post-surgery [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Cost-effectiveness of dental antibiotic prophylaxis in total knee arthroplasty recipients with type II diabetes mellitus

Stanley

Trentadue

Smith

et al. 2020

Osteoarthritis and Cartilage Open

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Section: Introductionmentioning

confidence: 99%

Cost-effectiveness of dental antibiotic prophylaxis in total knee arthroplasty recipients with type II diabetes mellitus

Stanley

Trentadue

Smith

et al. 2020

Osteoarthritis and Cartilage Open

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Do Genetic Susceptibility, Toll-like Receptors, and Pathogen-associated Molecular Patterns Modulate the Effects of Wear?

Greenfield

2014

Clin Orthop Relat Res

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Background Overwhelming evidence supports the concept that wear particles are the primary initiator of aseptic loosening of orthopaedic implants. It is likely, however, that other factors modulate the biologic response to wear particles. This review focuses on three potential other factors: genetic susceptibility, Toll-like receptors (TLRs), and bacterial pathogen-associated molecular patterns (PAMPs). Where Are We Now? Considerable evidence is emerging that both genetic susceptibility and TLR activation are important factors that modulate the biologic response to wear particles, but it remains controversial whether bacterial PAMPs also do so. Where Do We Need to Go? Detailed understanding of the roles of these other factors may lead to identification of novel therapeutic targets for patients with aseptic loosening. How Do We Get There? Highest priority should be given to polymorphism replication studies with large numbers of patients and studies to replicate the reported correlation between bacterial biofilms and the severity of aseptic loosening.

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LbL-assembled gentamicin delivery system for PMMA bone cements to prolong antimicrobial activity

et al. 2018

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IntroductionAntibiotic-loaded poly(methyl methacrylate) bone cements (ALBCs) are widely used in total joint replacement (TJR), for local delivery of antibiotics to provide prophylaxis against prosthetic joint infections (PJI). One of the shortcomings of the current generation of ALBCs is that the antibiotic release profile is characterized by a burst over the first few hours followed by a sharp decrease in rate for the following several days (often below minimum inhibitory concentration (MIC)), and, finally, exhaustion (after, typically, ~ 20 d). This profile means that the ALBCs provide only short-term antimicrobial action against bacterial strains involved PJI.RationaleThe purpose of the present study was to develop an improved antibiotic delivery system for an ALBC. This system involved using a layer-by-layer technique to load the antibiotic (gentamicin sulphate) (GEN) on silica nanoparticles, which are then blended with the powder of the cement. Then, the powder was mixed with the liquid of the cement (NP-GEN cement). For controls, two GEN-loaded brands were used (Cemex Genta and Palacos R+G). Gentamicin release and a host of other relevant properties were determined for all the cements studied.ResultsCompared to control cement specimens, improved GEN release, longer antimicrobial activity (against clinically-relevant bacterial strains), and comparable setting time, cytocompatibility, compressive strength (both prior to and after aging in PBS at 37 oC for 30 d), 4-point bend strength and modulus, fracture toughness, and PBS uptake.ConclusionsNP-GEN cement may have a role in preventing or treating PJI.

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Prevention of Late PJI

Cited by 4 publications

References 211 publications

Cost-effectiveness of dental antibiotic prophylaxis in total knee arthroplasty recipients with type II diabetes mellitus

Cost-effectiveness of dental antibiotic prophylaxis in total knee arthroplasty recipients with type II diabetes mellitus

Do Genetic Susceptibility, Toll-like Receptors, and Pathogen-associated Molecular Patterns Modulate the Effects of Wear?

LbL-assembled gentamicin delivery system for PMMA bone cements to prolong antimicrobial activity

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