Prevention of Ischemic Brain Damage Following Cardiac Arrest

Mogensen, L.

doi:10.1007/978-3-642-83456-1_20

Cited by 1 publication

(1 citation statement)

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“…Clin ically feasible methods include a head hood or hel met with chemical cooling (Brader, 1988), head im mersion in ice water, and nasopharyngeal cooling after tracheal intubation (Natale and D' Alecy, 1989). The temperature gradients we achieved by surface cooling match those obtained by computer modeling (Mogensen, 1988). During no flow of 12.…”

Section: Discussionmentioning

confidence: 63%

Mild Cerebral Hypothermia during and after Cardiac Arrest Improves Neurologic Outcome in Dogs

Leonov

Sterz

Šafář

et al. 1990

J Cereb Blood Flow Metab

346

118

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Summary: We previously found mild hypothermia (34-36°C), induced before cardiac arrest, to improve neu rologic outcome. In this study we used a reproducible dog model to evaluate mild hypothermia by head cooling dur ing arrest, continued with systemic cooling (34°C) during recirculation and for 1 h after arrest. In four groups of dogs, ventricular fibrillation (no flow) of 12.5 min at 37 SC was reversed with cardiopulmonary bypass and defibrillation in �5 min, and followed by controlled ven tilation to 20 h and intensive care to 96 h. In Study A we resuscitated with normotension and normal hematocrit; Control Group A-I (n = 12) was maintained normother mic, while Treatment Group A-II (n = 10) was treated with hypothermia. In Study B we resuscitated with hy pertension and hemodilution. Control Group B-1 (n = 12) was maintained normothermic (6 of 12 were not hemodi luted), while Treatment Group B-II (n = 10) was treated with hypothermia. Best overall performance categories This study concerns two relatively unexplored concepts: (a) hypothermia initiated during ischemia (preservation) and continued after ischemia (resus citation) in contrast to hypothermia initiated before ischemia (protection), which is known to mitigate postischemic brain damage (Bigelow et aI. , 1950;Rupp and Severinghaus, 1986); (b) mild hypother mia (temperature 34-36°C) in contrast to moderate hypothermia (28-32°C), which is known to protect the brain (Bigelow et aI. , 1950) and may be harmful. This study involves cardiac arrest (i. e. , total body

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Section: Discussionmentioning

confidence: 63%