Prevention of intradialytic hypotensive episodes: is setraline an effective pharmacological approach?

Georgianos, Panagiotis I.; Agarwal, Rajiv

doi:10.1590/2175-8239-jbn-2019-0175

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…However, as Georgianos and Agarwal commented in their paper, the study of Molin and colleagues may suffer from some methodological limitations, such as a small number of participants, single-blind, and no cross-over design. Furthermore, they conclude that sertraline, as a mood-enhancing agent, may be beneficial to reduce the number of uncomfortable intradialytic symptoms and nursing interventions [84].…”

Section: Intradialytic Hypotensionmentioning

confidence: 99%

Use of Sertraline in Hemodialysis Patients

et al. 2021

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Depression and anxiety are the most common psychiatric disorders in end-stage renal disease (ESRD) patients treated with hemodialysis (HD) and may correlate with lower quality of life and increased mortality. Depression treatment in HD patients is still a challenge both for nephrologists and psychiatrists. The possible treatment of depressive disorders can be pharmacological and non-pharmacological. In our article, we focus on the use of sertraline, the medication which seems to be relatively safe and efficient in the abovementioned population, taking under consideration several limitations regarding the use of other selective serotonin reuptake inhibitors (SSRIs). In our paper, we discuss different aspects of sertraline use, taking into consideration possible benefits and side effects of drug administration like impact on QTc (corrected QT interval) prolongation, intradialytic hypotension (IDH), chronic kidney disease-associated pruritus (CKD-aP), bleeding, sexual functions, inflammation, or fracture risk. Before administering the medication, one should consider benefits and possible side effects, which are particularly significant in the treatment of ESRD patients; this could help to optimize clinical outcomes. Sertraline seems to be safe in the HD population when provided in proper doses. However, we still need more studies in this field since the ones performed so far were usually based on small samples and lacked placebo control.

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Section: Intradialytic Hypotensionmentioning

confidence: 99%

Use of Sertraline in Hemodialysis Patients

et al. 2021

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“…Hemodialysis is associated with several complications like intradialytic hypotension (IDH), with an incidence rate reaching approximately 20%-30% worldwide while, in a study conducted in Egypt, this rate was reported as 90% (Narouz & El-Sayed, 2019). IDH is described by the European Best Practice Guidelines as a reduction in systolic blood pressure (SBP) during dialysis by 20 mmHg or a 10 mmHg decrease in the mean arterial pressure, followed by common related symptoms i.e., nausea, vomiting, abdominal discomfort, muscle cramps, pruritis, fatigue and light-headedness which need nurses' intervention (Georgianos & Agarwal, 2019;Park et al, 2019;Molin et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Are Cooling Dialysate and Patient Education Can Decrease Intradialytic Hypotension?

Elpasiony¹,

Kahraman

Sobh³

2022

Egyptian Journal of Health Care

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Background: Intradialytic hypotension (IDH) is a common and distressful complication of hemodialysis. It can cause uncomfortable symptoms for patients, lower dialysis efficiency, and result in vascular access thrombosis. Therefore, preventing this complication is essential. Aim: To evaluate the effects of cooling the dialysate and patient education on decreasing intradialytic hypotension. Design A Quasi-experimental study design was used. Methods A purposive 70 patients undergoing hemodialysis in a hospital in Egypt participated in the study. Tool I (Structured Interviewing Questionnaires Sheet) and Tool II (Intradialytic hypotension Assessment Sheet) were used to collect data. Interventions include educate patients some instructions help in decrease IDH. In addition, lower dialysate temperature. Results A statistically significant difference in the occurrence of intradialytic hypotension was observed between pre and post intervention during every hour of hemodialysis (p < 0.01). Also, more than half of the patients reported symptoms of intradialytic hypotension before intervention, including fatigue, sweating, cramps, and dizziness with a statistically significant difference from those after intervention (p = 0.001). Conclusion: As a result of the intervention done, the symptoms observed during dialysis and the prevalence of IDH decreased. Recommendations: Cooling the dialysate and educating patients instructions regarding diet and dealing with drugs can be routinely applied to prevent IDH in hemodialysis units.

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Prevention of intradialytic hypotensive episodes: is setraline an effective pharmacological approach?

Abstract: Prevention of intradialytic hypotensive episodes: is setraline an effective pharmacological approach?Prevenção da hipotensão intradialítica: seria a sertralina uma abordagem farmacológica eficaz?

Cited by 2 publications

References 12 publications

Use of Sertraline in Hemodialysis Patients

Use of Sertraline in Hemodialysis Patients

Are Cooling Dialysate and Patient Education Can Decrease Intradialytic Hypotension?

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