Prevention of Increased Hemoglobin-Oxygen Affinity in Open-Heart Operations with Inosine-Phosphate-Pyruvate Solution

Giannelli, Stanley; McKenna, Joseph P.; Bordiuk, Joseph; Miller, Leonard D.; Jerome, Carl R.

doi:10.1016/s0003-4975(10)63886-6

Cited by 9 publications

(5 citation statements)

References 16 publications

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“…Design of blinded clinical trials using sodium pyruvate will not be difficult given its mild side effects profile (Fujii et al, ). Pyruvate has been administered to patients for a variety of conditions (Dijkstra et al, ; Fujii et al, ; Giannelli et al, ; Hermann, ; Hermann et al, ; Koga et al, ; Olivencia‐Yurvati et al, ; Tanaka et al, ) and deserves considerations for peripheral neuropathies, disorders with a limited repertoire of treatment options.…”

Section: Discussionmentioning

confidence: 99%

“…We report here that exogenous sodium pyruvate added to drinking water in Tr J mice increased myelinated fiber (MF) density and myelin thickness in the sciatic nerves, resulting improvements in functional and electrophysiological parameters. These observations have direct relevance to potential treatment value of pyruvate supplementation in peripheral neuropathies with diverse causes in considering the fact that clinically, sodium pyruvate has already been given to patients for a variety of conditions from Friedreich’s ataxia, mitochondrial disease to open heart surgery (Dijkstra et al, ; Fujii et al, ; Giannelli, McKenna, Bordiuk, Miller, & Jerome, ; Koga et al, ; Olivencia‐Yurvati, Blair, Baig, & Mallet, ; Tanaka et al, ) and acute heart failure (Hermann, ; Hermann et al, ). Moreover, we show in a CMT mouse model that combining pyruvate supplementation with the proven efficacy from adeno‐associated virus‐NT‐3 (AAV1.NT‐3) gene therapy enhanced peripheral nerve function and improved histology as proof of principal for a combinatorial treatment approach.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of exogenous pyruvate in Trembler^J mouse model of Charcot‐Marie‐Tooth neuropathy

et al. 2018

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IntroductionClassic Charcot‐Marie‐Tooth (CMT) neuropathies including those with Schwann cell genetic defects exhibit a length‐dependent process affecting the distal axon. Energy deprivation in the distal axon has been the proposed mechanism accounting for length‐dependent distal axonal degeneration. We hypothesized that pyruvate, an intermediate glycolytic product, could restore nerve function, supplying lost energy to the distal axon.MethodsTo test this possibility, we supplied pyruvate to the drinking water of the Trembler‐J (TrJ) mouse and assessed efficacy based on histology, electrophysiology, and functional outcomes. Pyruvate outcomes were compared with untreated TrJ controls alone or adeno‐associated virus mediated NT‐3 gene therapy (AAV1.NT‐3)/pyruvate combinatorial approach.ResultsPyruvate supplementation resulted increased myelinated fiber (MF) densities and myelin thickness in sciatic nerves. Combining pyruvate with proven efficacy from AAV1.tMCK.NT‐3 gene therapy provided additional benefits showing improved compound muscle action potential amplitudes and nerve conduction velocities compared to pyruvate alone cohort. The end point motor performance of both the pyruvate and the combinatorial therapy cohorts was better than untreated TrJcontrols. In a unilateral sciatic nerve crush paradigm, pyruvate supplementation improved myelin‐based outcomes in both regenerating and the contralateral uncrushed nerves.ConclusionsThis proof of principle study demonstrates that exogenous pyruvate alone or as adjunct therapy in TrJ may have clinical implications and is a candidate therapy for CMT neuropathies without known treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of exogenous pyruvate in Trembler^J mouse model of Charcot‐Marie‐Tooth neuropathy

et al. 2018

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“…2, 3) (résultats non publiés). Comme l'ont également souligné Giannelli et al [7], il existe une augmentation très impor tante de l'affinité de l'Hb pour l'oxygène. Dans notre travail, tous les sangs ACD utilisés avaient des taux d'HbCO bas.…”

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Tabagisme et carboxyhémoglobine chez les donneurs de sang

et al. 1983

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The authors studied the tobacco consumption of 283 blood donors and its consequences. 151 were nonsmokers and 132 were smokers (47.7% smoke more than 10 g/day). Their mean HbCO level was 4.3 ± 0.2% (highest level 15%). HbCO levels are significantly correlated with daily tobacco consumption (p < 0.001) and can be estimated with the following regression equation: HbCO% = 0.176 (tobacco in grams/day) + 1.967. For a similar consumption, inhalers exhibit significantly (p < 0.001) higher HbCO levels than noninhalers and the increase is significantly higher (p < 0.02) in inhalers who smoked 1 h or less prior to blood sampling. High HbCO levels have two consequences: in the donors they have caused a tobacco polycythemia syndrome and in the recipients they have caused acute problems in cases of massive blood transfusion and cardiovascular surgery with extracorporeal circulation

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“… 15 , 16 Clinically, sodium pyruvate has a good safety profile and has been given to patients for a variety of disorders ranging from Friedreich's ataxia 17 to open heart operations. 18 It has been administered via several routes, including intravenous, 18 topical administration, 19 dietary supplementation, 20 and intranasally. 15 , 16 The purpose of the five studies presented here was to test the therapeutic value of sodium pyruvate to improve nasal inflammation in patients with AR.…”

Section: Introductionmentioning

confidence: 99%

Sodium Pyruvate Nasal Spray Reduces the Severity of Nasal Inflammation and Congestion in Patients with Allergic Rhinitis

Martin¹,

Lupfer

Amen³

2022

Journal of Aerosol Medicine and Pulmonary Drug Delivery

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Background: As an anti-inflammatory and antioxidant, sodium pyruvate significantly reduces inflammatory cytokines and oxygen radicals such as interleukin (IL) IL-6, IL-8, Monocyte Chemoattractant Protein-1, and hydrogen peroxide. Thus, sodium pyruvate holds promise as a treatment for many respiratory diseases, including allergic rhinitis (AR). Novel treatments for AR are needed as current medications, including steroids, often fail to treat severe symptoms. Methods: The data from five human clinical studies were analyzed to determine the effect of 20 mM sodium pyruvate nasal spray (N115) in patients with AR. Nasal inflammation scores were compared to a placebo control or a no-treatment baseline control. Three studies were open-labeled and two were appropriately blinded to both patients and clinicians using computer randomization of subjects. Results: The intranasal administration of sodium pyruvate significantly improved nasal inflammation scores in all five clinical trials of patients with AR ( p < 0.0001 in all trials). Conclusions: These results give credence to the overall ability of sodium pyruvate, administered by nasal spray, to treat inflammation of the nasal airways.

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Prevention of Increased Hemoglobin-Oxygen Affinity in Open-Heart Operations with Inosine-Phosphate-Pyruvate Solution

Cited by 9 publications

References 16 publications

Efficacy of exogenous pyruvate in Trembler^J mouse model of Charcot‐Marie‐Tooth neuropathy

Efficacy of exogenous pyruvate in Trembler^J mouse model of Charcot‐Marie‐Tooth neuropathy

Tabagisme et carboxyhémoglobine chez les donneurs de sang

Sodium Pyruvate Nasal Spray Reduces the Severity of Nasal Inflammation and Congestion in Patients with Allergic Rhinitis

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Prevention of Increased Hemoglobin-Oxygen Affinity in Open-Heart Operations with Inosine-Phosphate-Pyruvate Solution

Cited by 9 publications

References 16 publications

Efficacy of exogenous pyruvate in TremblerJ mouse model of Charcot‐Marie‐Tooth neuropathy

Efficacy of exogenous pyruvate in TremblerJ mouse model of Charcot‐Marie‐Tooth neuropathy

Tabagisme et carboxyhémoglobine chez les donneurs de sang

Sodium Pyruvate Nasal Spray Reduces the Severity of Nasal Inflammation and Congestion in Patients with Allergic Rhinitis

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Efficacy of exogenous pyruvate in Trembler^J mouse model of Charcot‐Marie‐Tooth neuropathy

Efficacy of exogenous pyruvate in Trembler^J mouse model of Charcot‐Marie‐Tooth neuropathy