Prevention of impulse noise-induced hearing loss with antioxidants

Kopke, Richard D.; Bielefeld, Eric C.; Liu, Jianzhong; Zheng, Jiefu; Jackson, Ronald L.; Henderson, Donald; Coleman, John K.M.

doi:10.1080/00016480410023038

Cited by 124 publications

(117 citation statements)

References 18 publications

Supporting

Mentioning

105

Contrasting

Unclassified

Order By: Relevance

“…In addition, some otoprotectants may be able to rescue damaged cells once injury has occurred, thereby minimizing hearing loss. There have been numerous studies of various compounds used to protect hearing loss, ranging from antioxidants that scavenge free radicals to agents that increase blood flow and drugs that block cell-death-pathway signaling factors [69][70][71]. Despite the potential these investigations bring for protection from hearing damage, the translation of animal studies of otoprotectants to clinical treatment has been limited.…”

Section: Preventionmentioning

confidence: 99%

Auditory and vestibular dysfunction associated with blast-related traumatic brain injury

Fausti¹,

Wilmington²,

Gallun³

et al. 2009

JRRD

186

117

View full text Add to dashboard Cite

Abstract-The dramatic escalation of blast exposure in military deployments has created an unprecedented amount of traumatic brain injury (TBI) and associated auditory impairment. Auditory dysfunction has become the most prevalent individual service-connected disability, with compensation totaling more than 1 billion dollars annually. Impairment due to blast can include peripheral hearing loss, central auditory processing deficits, vestibular impairment, and tinnitus. These deficits are particularly challenging in the TBI population, as symptoms can be mistaken for posttraumatic stress disorder, mentalhealth issues, and cognitive deficits. In addition, comorbid factors such as attention, cognition, neuronal loss, noise toxicity, etc., can confound assessment, causing misdiagnosis. Furthermore, some auditory impairments, such as sensorineural hearing loss, will continue to progress with age, unlike many other injuries. In the TBI population, significant clinical challenges are the accurate differentiation of auditory and vestibular impairments from multiple, many times overlapping, symptoms and the development of multidisciplinary rehabilitation strategies to improve treatment outcomes and quality of life for these patients.

show abstract

Section: Preventionmentioning

confidence: 99%

Auditory and vestibular dysfunction associated with blast-related traumatic brain injury

Fausti¹,

Wilmington²,

Gallun³

et al. 2009

JRRD

186

117

View full text Add to dashboard Cite

show abstract

“…PBN and its derivatives have been successfully tried on several rodent models of cancer and seem to be promising [201]. Nitrones seem also to be effective on animal models of hearing loss [202][203][204].…”

Section: Nitronesmentioning

confidence: 99%

Clinical and pharmacological aspects of bath salt use: A review of the literature and case reports

Miotto¹,

Striebel²,

Cho

et al. 2013

Drug and Alcohol Dependence

121

View full text Add to dashboard Cite

Abstract:Reactive oxygen species (ROS) are widely believed to cause or aggravate several human pathologies such as neurodegenerative diseases, cancer, stroke and many other ailments. Antioxidants are assumed to counteract the harmful effects of ROS and therefore prevent or treat oxidative stress-related diseases. In this report, recent human studies exploring the efficiency of antioxidants in prevention and treatment of various diseases are reviewed. Few antioxidants including edaravone (for ischemic stroke in Japan), Nacetylcysteine (for acetaminophen toxicity), alfa-lipoic acid (for diabetic neuropathy) and some flavonoids (polyphenolic compounds present in dietary plants), such as micronized purified flavonoid fraction (diosmin and hesperidin) and oxerutins (for chronic venous insufficiency) as well as baicalein and catechins (for osteoarthritis) have found accepted clinical use. However, despite much enthusiasm in the 1980s and 1990s, many well-known agents such as antioxidant vitamins and also more recently developed compounds such as nitrones have not successfully passed the scrutiny of clinical trials for prevention and treatment of various diseases. This has given rise to a pessimistic view of antioxidant therapy, however, the evidence from human epidemiological studies about the beneficial effects of dietary antioxidants and preclinical in vitro and animal data are compelling. We have probably wasted too much time on agents like antioxidant vitamins instead of focusing on more disease specific, target-directed, highly bioavailable antioxidants. We here discuss possible reasons for the lack of success in some clinical trials and seek to provide some suggestions to be considered if antioxidant therapy is to succeed as an effective therapeutic strategy.

show abstract

“…The incidence of noise-induced hearing loss (NIHL) continues to grow, moreover, partly due to growing popularity of portable music players with highly efficient headphones (Fligor and Cox, 2004;Serra et al, 2005). Although several promising approaches have been identified for reducing NIHL (Lefebvre et al, 2002;Niu and Canlon 2002;Kopke et al, 2005;Lynch and Kil 2005;Le Prell et al, this volume;Gagnon et al, this volume), there are currently no pharmacologic agents approved by the Food and Drug Administration (FDA) for this purpose.…”

Section: Introductionmentioning

confidence: 99%

Prophylactic and therapeutic functions of T-type calcium blockers against noise-induced hearing loss

et al. 2007

View full text Add to dashboard Cite

Cochlear noise injury is the second most frequent cause of sensorineural hearing loss, after aging. Because calcium dysregulation is a widely recognized contributor to noise injury, we examined the potential of calcium channel blockers to reduce noise-induced hearing loss (NIHL) in mice. We focused on two T-type calcium blockers, trimethadione and ethosuximide, which are anti-epileptics approved by the Food and Drug Administration. Young C57BL/6 mice of either gender were divided into three groups: a 'prevention' group receiving the blocker via drinking water before noise exposure; a 'treatment' group receiving the blocker via drinking water after noise exposure; and controls receiving noise alone. Trimethadione significantly reduced NIHL when applied before noise exposure, as determined by auditory brainstem recording. Both ethosuximide and trimethadione were effective in reducing NIHL when applied after noise exposure. Results were influenced by gender, with males generally receiving greater benefit than females. Quantitation of hair cell and neuronal density suggested that preservation of outer hair cells could account for the observed protection. Immunocytochemistry and RT-PCR suggested that this protection involves direct action of T-type blockers on α1 subunits comprising one or more Ca v 3 calcium channel types in the cochlea. Our findings provide a basis for clinical studies testing T-type calcium blockers both to prevent and treat NIHL.

show abstract

Prevention of impulse noise-induced hearing loss with antioxidants

Abstract: Three weeks after exposure, permanent threshold shifts for the experimental groups were significantly reduced to approximately = 10-30 dB less than that for the control group (p < 0.01). Less hair cell loss was also observed in the ALCAR and NAC groups than in the control group.

Cited by 124 publications

References 18 publications

Auditory and vestibular dysfunction associated with blast-related traumatic brain injury

Auditory and vestibular dysfunction associated with blast-related traumatic brain injury

Clinical and pharmacological aspects of bath salt use: A review of the literature and case reports

Prophylactic and therapeutic functions of T-type calcium blockers against noise-induced hearing loss

Contact Info

Product

Resources

About