Prevention of Hyaline Membrane Disease With Plasminogen

Ambrus, Clara M.

doi:10.1001/jama.1977.03270440027015

Cited by 22 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the 1970s, plasminogen administration was used for very premature infants with respiratory distress syndrome because of its fibrinolytic effect. Ambrus et al performed several double-blind, randomized clinical trials and found that plasminogen administration decreased severe respiratory distress and mortality without apparent side effects [ 44 ]. In this study, the effects of plasminogen on the DA were not assessed.…”

Section: Discussionmentioning

confidence: 99%

Tissue-type plasminogen activator contributes to remodeling of the rat ductus arteriosus

et al. 2018

View full text Add to dashboard Cite

AimsThe ductus arteriosus (DA) closes after birth to adapt to the robust changes in hemodynamics, which require intimal thickening (IT) to occur. The smooth muscle cells of the DA have been reported to play important roles in IT formation. However, the roles of the endothelial cells (ECs) have not been fully investigated. We herein focused on tissue-type plasminogen activator (t-PA), which is a DA EC dominant gene, and investigated its contribution to IT formation in the DA.Methods and resultsECs from the DA and aorta were isolated from fetal rats using fluorescence-activated cell sorting. RT-PCR showed that the t-PA mRNA expression level was 2.7-fold higher in DA ECs than in aortic ECs from full-term rat fetuses (gestational day 21). A strong immunoreaction for t-PA was detected in pre-term and full-term rat DA ECs. t-PA-mediated plasminogen-plasmin conversion activates gelatinase matrix metalloproteinases (MMPs). Gelatin zymography revealed that plasminogen supplementation significantly promoted activation of the elastolytic enzyme MMP-2 in rat DA ECs. In situ zymography demonstrated that marked gelatinase activity was observed at the site of disruption in the internal elastic laminae (IEL) in full-term rat DA. In a three-dimensional vascular model, EC-mediated plasminogen-plasmin conversion augmented the IEL disruption. In vivo administration of plasminogen to pre-term rat fetuses (gestational day 19), in which IT is poorly formed, promoted IEL disruption accompanied by gelatinase activation and enhanced IT formation in the DA. Additionally, experiments using five human DA tissues demonstrated that the t-PA expression level was 3.7-fold higher in the IT area than in the tunica media. t-PA protein expression and gelatinase activity were also detected in the IT area of the human DAs.Conclusiont-PA expressed in ECs may help to form IT of the DA via activation of MMP-2 and disruption of IEL.

show abstract

Section: Discussionmentioning

confidence: 99%

Tissue-type plasminogen activator contributes to remodeling of the rat ductus arteriosus

et al. 2018

View full text Add to dashboard Cite

show abstract

“…This shows that partly solving one set of problems may bring about new problems. Another major cause of infantile death in developing countries is malnutrition related respiratory-distress syndrome-hyaline membrane disease often complicated with massive superinfections (63)(64)(65). In areas where there was improved nutrition, there also appeared to be a decreased incidence of this disease.…”

Section: Mechanisms and Remedies The First Criticalmentioning

confidence: 99%

Nutrition and Infectious Diseases in Developing Countries and Problems of Acquired Immunodeficiency Syndrome

Ambrus

2004

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

Infectious diseases are the major causes of death and morbidity in underdeveloped countries, particularly in children. Increasing evidence suggests that malnutrition-both Protein-Energy type Malnutrition (PEM) and essential micronutrient (vitamins, trace minerals, essential amino acids, polyunsaturated fatty acids) type-is the underlying reason for increased susceptibility to infections. On the other hand, certain infectious diseases also cause malnutrition, which results in a vicious cycle. Before its viral origin was known, acquired immunodeficiency syndrome (AIDS) had been termed the thin disease because cachexia was AIDS' main clinical manifestation. The relationship between infection and malnutrition is well documented in the literature. Our experience supports this. Preventive and therapeutic measures are suggested.

show abstract

“…The theory that hyaline membranes resulted from shock, fi brinolysin defi ciency or disseminated intravascular coagulation, persisted for 20 years and stimulated several therapeutic approaches directed at infl uencing coagulation. Plasminogen infusions, recommended in 1977 by Ambrus et al [31] following a double-blind study of 500 preterm infants, was believed to decrease the severity of HMD and overall neonatal mortality. Infants with HMD were thought to have low levels of serum plasminogen.…”

Section: Pathology Of the Hyaline Membranementioning

confidence: 99%

History of Surfactant up to 1980

Obladen

2005

Neonatology

View full text Add to dashboard Cite

Remarkable insight into disturbed lung mechanics of preterm infants was gained in the 18th and 19th century by the founders of obstetrics and neonatology who not only observed respiratory failure but also designed devices to treat it. Surfactant research followed a splendid and largely logical growth curve. Pathological changes in the immature lung were characterized in Germany by Virchow in 1854 and by Hochheim in 1903. The Swiss physiologist von Neergard fully understood surfactant function in 1929, but his paper was ignored for 25 years. The physical properties of surfactant were recognized in the early 1950s from research on warfare chemicals by Pattle in Britain and by Radford and Clements in the United States. The causal relationship of respiratory distress syndrome (RDS) and surfactant deficiency was established in the USA by Avery and Mead in 1959. The Australian obstetrician Liggins induced lung maturity with glucocorticoids in 1972, but his discovery was not fully believed for another 20 years. A century of basic research was rewarded when Fujiwara introduced surfactant substitution in Japan in 1980 for treatment and prevention of RDS.

show abstract

Prevention of Hyaline Membrane Disease With Plasminogen

Cited by 22 publications

References 11 publications

Tissue-type plasminogen activator contributes to remodeling of the rat ductus arteriosus

Tissue-type plasminogen activator contributes to remodeling of the rat ductus arteriosus

Nutrition and Infectious Diseases in Developing Countries and Problems of Acquired Immunodeficiency Syndrome

History of Surfactant up to 1980

Contact Info

Product

Resources

About