Prevention of heterotopic ossification after total hip replacement: A prospective comparison of indomethacin and salmon calcitonin in 60 patients

Günal, İzge; Hazer, Bülent; Seber, Sinan; Göktürk, Erol; Turgut, Akin; Köse, Nusret

doi:10.1080/000164701753532781

Cited by 21 publications

(6 citation statements)

References 16 publications

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“…There is substantial case-control evidence that combined nonsteroidal antiinflammatory medications and local radiation therapy may have an additive or synergistic beneficial effect in the prevention of recurrence as compared with the effect of monotherapy with either modality alone [53][54][55][56] . Numerous other agents, including the early bisphosphonate etidronate, have been studied in human and animal trials of heterotopic ossification prevention, with varying levels of success and supporting evidence [57][58][59][60][61][62][63][64][65][66] .…”

Section: Primary and Secondary Prophylaxis Against Heterotopic Ossifimentioning

confidence: 99%

Heterotopic Ossification Following Traumatic and Combat-Related Amputations

Potter

Burns

Lacap

et al. 2007

The Journal of Bone & Joint Surgery

227

130

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Heterotopic ossification following trauma-related amputation is more common than the literature would suggest, particularly following amputations that are performed within the initial zone of injury and those that are due to blast injuries. Many patients are asymptomatic or can be successfully managed with modification of the prosthesis. For patients with refractory symptoms, surgical excision is associated with low recurrence rates and decreased medication requirements, with acceptable complication rates.

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Section: Primary and Secondary Prophylaxis Against Heterotopic Ossifimentioning

confidence: 99%

Heterotopic Ossification Following Traumatic and Combat-Related Amputations

Potter

Burns

Lacap

et al. 2007

The Journal of Bone & Joint Surgery

227

130

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“…1,7,18 However, in the present study, no relationship was found between the 2 variables. Studies of total hip replacement have reported that NSAIDs may prevent HO, 8,10,17,34 but the actual effect of NSAIDs in cervical arthroplasty on HO has not been determined. In the present study, we encountered a high rate of HO, despite routinely administering NSAIDs for more than 2 weeks following surgery, which casts doubts on the idea of HO prevention using NSAIDs.…”

mentioning

confidence: 99%

Radiological changes of the operated and adjacent segments following cervical arthroplasty after a minimum 24-month follow-up: comparison between the Bryan and Prodisc-C devices

Ryu¹,

Park²,

Jun³

et al. 2010

SPI

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Object. The purposes of this retrospective study were to determine the radiological changes at the index and adjacent levels after cervical arthroplasty using the Bryan disc and Prodisc-C disc after a minimum 24 months followup, and to demonstrate the possible clinical factors related to these changes. Methods. Following single-level cervical arthroplasty using either the Bryan disc or Prodisc-C, the degree of facet degeneration and other radiological changes at the index and adjacent levels were assessed by observing radiographs and CT scans at a minimum 24 months after the operations. These findings were determined in relation to the clinical outcome, various perioperative factors, and prosthesis factors. Thirty-six patients were included in this investigation (19 in the Bryan disc group and 17 in the Prodisc-C group).Results. At the index level, progression of facet arthrosis (PFA) was observed in 7 of 36 levels (1 level with the Bryan disc, 6 with the Prodisc-C). At adjacent levels, PFA was minimally observed. Heterotopic ossification (HO) was observed at 19 levels (11 with the Bryan disc, 8 with Prodisc-C). Progression of facet arthrosis at the index segments was positively related to malposition of the prosthesis on the frontal plane, and decreased postoperative functional spinal unit range of motion at the index level. Occurrence of HO was correlated with the preoperative calcification of the posterior longitudinal ligament at the operated level, regardless of prosthesis type. Clinical outcome and the occurrence of PFA or HO did not show any significant relationship.Conclusions. This study demonstrates that the incidence of PFA at the index level is 19.4% after a minimum 24-month follow-up, and occurs more frequently in the Prodisc-C group. Progression of facet arthrosis is related to less functional spinal unit range of motion and anterior placement of the prosthesis. The occurrence rate of HO is high, regardless of the type of prosthesis, and it is significantly correlated with preoperative calcification of the posterior longitudinal ligament at the operated level. (DOI: 10.3171/2010.3.SPINE09445) Key WoRDS

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“…Calcitonin did not promote any pain relief in comparison with the placebo group. Calcitonin has also been used after hip replacement to prevent heterotopic bone formation after total hip replacement (27). In this study, no heterotopic ossification was seen in either group during the 12 month study period.…”

Section: Discussionmentioning

confidence: 99%