Prevention of Glomerulonephritis and Prolonged Survival in New Zealand Black/New Zealand White F1 Hybrid Mice Fed an Essential Fatty Acid-deficient Diet

Diet therapy for rheumatoid arthritis

“…These observations suggest that environmental antigens may play a role in certain immunologic diseases. It is generally accepted that the gastrointestinal tract is permeable to macromolecules (42), that autoimmunity to bovine and food antigens may occur (43)(44)(45)(46), and that nutritional modulation alters experimental autoimmunity (10)(11)(12)(13)(14)(15)(16)(17).…”

Arachidonate metabolism in vascular disorders.

“…That changes in the natural history of diseases may be achieved by altering eicosanoid precursor availability is suggested by recent studies in New Zealand black/New Zealand white mice with autoimmune nephritis. These mice were fed diets deficient in arachidonate (44) or diets supplemented with eicosapentaenoic acid (20:5) (45), which competes with arachidonate, resulting in a reduction in active eicosanoid mediators. In both these eicosanoid-deficient states there is an amelioration of the autoimmune nephritis.…”

Effects of fasting on disease activity, neutrophil function, fatty acid composition, and leukotriene biosynthesis in patients with rheumatoid arthritis

“…A similar marine diet has been shown to reduce symptoms in RA patients (15). Likewise, diets deficient in essential fatty acids or diets enriched with EPA protect (New Zealand black X New Zealand white)Fi, mice from autoimmune glomerulonephritis (16,17). EPA-enriched diets also reduce the synthesis of endogenous dienoic prostaglandins (18).…”