Prevention of Gallstone Recurrence by Non-Steroidal Anti-Inflammatory Drugs

Hood, K. A.; Ruppin, D.C.; Gleeson, D.; Dowling, R. H.

doi:10.1016/s0140-6736(88)90812-4

Cited by 82 publications

(25 citation statements)

References 21 publications

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“…Although some clinical investigations and one observational study have suggested that NSAIDs may inhibit gallstone formation (13)(14)(15)(16)(17)(18), our finding of no association is consistent with two population studies that reported no difference in hospitalization for gallstone disease (19) or in gallstone prevalence (20) between users and nonusers of aspirin or NSAIDs. Future prospective studies examining the timing of NSAID use with respect to gallstone diagnosis are needed.…”

Section: Discussionsupporting

confidence: 89%

Aspirin Use and Risk of Biliary Tract Cancer: A Population-Based Study in Shanghai, China

Liu

Sakoda

Gao

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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The association of gallbladder and bile duct cancers with gallstones, cholecystitis, and cholangitis suggest that chronic inflammation contributes to the carcinogenic process. However, the effect of nonsteroidal anti-inflammatory drugs, such as aspirin, on biliary tract cancer has not been well studied. In a population-based case-control study conducted in Shanghai, China, we examined the relationship between aspirin use and the risk of biliary disease. A total of 627 patients with biliary tract cancer, including cancers of the gallbladder (n = 368), extrahepatic bile duct (n = 191), and ampulla of Vater (n = 68); 1,037 patients with biliary stones; and 958 healthy adults were included in the study. Self-reported data on aspirin use was collected from study participants by in-person interview. The prevalence of aspirin use was low, with 5.7% of the population controls being regular users. After controlling for age, sex, education, and biliary stone status, aspirin use was associated with a reduced risk of gallbladder cancer [odds ratio (OR), 0.37; 95% confidence interval (CI), 0.17-0.88]. An inverse relationship was also observed for frequency and duration of use and with younger age when starting use. In addition, there was a nonsignificant reduction in the risk of bile duct (OR, 0.48; 95% CI, 0.19-1.19) and ampullary cancers (OR, 0.22; 95% CI, 0.03-1.65) associated with aspirin use, whereas no clear association was seen with biliary stones (OR, 0.92; 95% CI,

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Section: Discussionsupporting

confidence: 89%

Aspirin Use and Risk of Biliary Tract Cancer: A Population-Based Study in Shanghai, China

Liu

Sakoda

Gao

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…62 Although a recall bias cannot be excluded, a pathogenic role of these conditions aspirin 24,[34][35][36] or other antirheumatic drugs 37 is commonly thought to be protective against gallstone formation, the through various mechanisms is conceivable. Diabetics could form cholesterol gallstones more frequently because of a remechanism postulated being the reduction of mucus production from the gallbladder.…”

Section: Resultsmentioning

confidence: 99%

Factors associated with gallstone disease in the MICOL experience

Attili¹,

Capocaccia²,

Carulli³

et al. 1997

Hepatology

176

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The epidemiological associations of gallstone disease were by age and sex have been extensively reported in a previous article, 1 and will be only briefly recalled here. This article evaluated in a general population sample of 29,584 individuals (15,910 men and 13,674 women; age range, 30-39 years) analyzes and discusses the relationships between gallstone disease and the associated individual factors. belonging to 14 cohorts examined between December 1984 and April 1987. Subjects were screened for the presence of PATIENTS AND METHODS gallstones by gallbladder ultrasonography, completed a questionnaire, and underwent a physical examination and blood Data Collection. The study protocol was prepared by the coordichemistry tests. Participants were considered to have gall-nating unit based on experience gained during the pioneering epidestone disease if they had already had cholecystectomy or gall-miological studies performed in Italy by the Rome Group for the stones. Statistical associations were established by univariate Epidemiology and Prevention of Cholelithiasis (GREPCO) 2-5 and analysis of the age-standardized data and by stepwise multiple the Sirmione project. 6 The examination included an interview with logistic regression. Increasing age and body mass index and the administration of a standard questionnaire, followed by a physia maternal family history of gallstone disease were the most cal and ultrasonographic examination of the upper abdomen and a blood sampling for biochemical analyses. Field activities started in consistent associations (both at univariate and multivariate were associated with gallstone disease in both sexes in the If not, have you ever smoked regularly? 3) Have you ever suffered multivariate analysis. In women, associations were also found from diabetes, gastric or duodenal ulcer, myocardial infarction or with a number of pregnancies and paternal family history angina, hepatic cirrhosis, Crohn's disease, or hemolytic anemia? of gallstone disease. A slight but negative association with 4) Have you ever regularly assumed serum lipid-lowering drugs, contraceptive pill use was identified only at multivariate anal-aspirin, or antirheumatic drugs? If yes, which and for how long? and 5) Have you ever been on a slimming diet? Women were also ysis. Associations (investigated at univariate analysis) were asked about the number of pregnancies and use of estroprogestinic also found with diabetes, cirrhosis, angina or myocardial indrugs. To estimate the prevalence of gallstone disease, the final farction, and peptic ulcer. There was no association with gallbladder status was recorded as follows: 1) normal at ultrasonogsmoking habits and use of aspirin or antirheumatic drugs. raphy; 2) presence of gallstones at ultrasonography; 3) presence of (HEPATOLOGY 1997;26:809-818.) biliary sludge at ultrasonography; 4) previous cholecystectomy; and 5) inconclusive or doubtful. Gallstone disease was defined as the presence of conditions 2 or 4. A blood sample was obtained fromThe MICOL study (Multicenter Ital...

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“…In addition, epidemiological studies examining the effects of NSAIDs on gallstone incidence and prevalence have also yielding conflicting results. In the postgallstone dissolution studies conducted by the British-Belgian Gallstone Study Group, none of 12 regular NSAID users developed recurrent gallstones after oral bile salt therapy compared to 32% of patients who did not use NSAIDs on a regular basis (35,36). In contrast, treatment with aspirin did not reduce the incidence of new gallstone formation for patients participating in a very low-calorie, rapid weight loss diet program (25) and Kurata et al (37) could not demonstrate that regular use of aspirin reduced the hospitalization rate for symptomatic gallstones among 4500 patients who participated in the Aspirin Myocardial Infarction Study.…”

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confidence: 99%